Differential expression of cyclin dependent kinase inhibitor 2C in cancers of the breast.

Cyclin Dependent Kinase ◽

Primary Tumors ◽

Cyclin Dependent Kinase Inhibitor

Breast cancer affects women at relatively high frequency (1). We mined published microarray datasets (2. 3) to determine in an unbiased fashion and at the systems level genes most differentially expressed in the primary tumors of patients with breast cancer. We report here significant differential expression of the gene encoding cyclin dependent kinase inhibitor 2C, CDKN2C, when comparing primary tumors of the breast to the tissue of origin, the normal breast. CDKN2C was also differentially expressed in the tumor cells of patients with triple negative breast cancer. CDKN2C mRNA was present at significantly lower quantities in tumors of the breast as compared to normal breast tissue. Analysis of human survival data revealed that expression of CDKN2C in primary tumors of the breast was correlated with overall survival in patients with basal-like and luminal A subtype cancer, demonstrating a relationship between primary tumor expression of a differentially expressed gene and patient survival outcomes influenced by PAM50 molecular subtype. CDKN2C may be of relevance to initiation, maintenance or progression of cancers of the female breast.

Differential expression of cyclin dependent kinase 1 in cancers of the breast.

10.31219/osf.io/d9hgc ◽

2021 ◽

Author(s):

Shahan Mamoor

Keyword(s):

Breast Cancer ◽

Overall Survival ◽

Differential Expression ◽

Survival Data ◽

Normal Breast ◽

Cyclin Dependent Kinase ◽

Primary Tumors ◽

Tumor Expression

Breast cancer affects women at relatively high frequency (1). We mined published microarray datasets (2, 3) to determine in an unbiased fashion and at the systems level genes most differentially expressed in the primary tumors of patients with breast cancer. We report here significant differential expression of the gene encoding cyclin dependent kinase 1, CDK1, when comparing primary tumors of the breast to the tissue of origin, the normal breast. CDK1 was also differentially expressed in the tumor cells of patients with triple negative breast cancer. CDK1 mRNA was present at significantly higher quantities in tumors of the breast as compared to normal breast tissue. Analysis of human survival data revealed that expression of CDK1 in primary tumors of the breast was correlated with overall survival in patients with stage III cancer, demonstrating an intricate relationship between correlation of primary tumor expression with overall survival based on stage of disease (progression). CDK1 may be of relevance to initiation, maintenance or progression of cancers of the female breast.

Differential expression of cyclin dependent kinase 2 (CDK2) in cancers of the breast.

10.31219/osf.io/kae5s ◽

2021 ◽

Author(s):

Shahan Mamoor

Keyword(s):

Breast Cancer ◽

Differential Expression ◽

Survival Data ◽

Molecular Subtype ◽

Normal Breast ◽

Cyclin Dependent Kinase ◽

Luminal A ◽

Breast cancer affects women at relatively high frequency (1). We mined published microarray datasets (2, 3) to determine in an unbiased fashion and at the systems level genes most differentially expressed in the primary tumors of patients with breast cancer. We report here significant differential expression of the gene encoding CDK2 (cyclin dependent kinase 2) when comparing primary tumors of the breast to the tissue of origin, the normal breast. CDK2 was also differentially expressed in the tumor cells of patients with triple negative breast cancer. CDK2 mRNA was present at significantly higher quantities in tumors of the breast as compared to normal breast tissue. Analysis of human survival data revealed that expression of CDK2 in primary tumors of the breast was correlated with recurrence-free survival in patients with luminal A subtype cancer, demonstrating a relationship between correlation of primary tumor expression with overall survival based on molecular subtype. We have now defined transcriptome-wide differential expression and up-regulation of CDK5 (4), CDK1 (5), and CDK2 in human breast cancer.

Differential expression of cyclin dependent kinase 5 in cancers of the breast.

10.31219/osf.io/ubsqn ◽

2021 ◽

Author(s):

Shahan Mamoor

Keyword(s):

Breast Cancer ◽

Differential Expression ◽

Survival Data ◽

Normal Breast ◽

Cyclin Dependent Kinase ◽

Luminal A ◽

Gene Encoding ◽

Primary Tumors ◽

Cyclin Dependent Kinase 5

Breast cancer affects women at relatively high frequency (1). We mined published microarray datasets (2, 3) to determine in an unbiased fashion and at the systems level genes most differentially expressed in the primary tumors of patients with breast cancer. We report here significant differential expression of the gene encoding cyclin dependent kinase 5, CDK5, when comparing primary tumors of the breast to the tissue of origin, the normal breast. CDK5 mRNA was present at significantly higher quantities in tumors of the breast as compared to normal breast tissue. Analysis of human survival data revealed that expression of CDK5 in primary tumors of the breast was correlated with distant metastasis-free survival in patients with luminal A subtype cancer. CDK5 may be of relevance to initiation, maintenance or progression of cancers of the female breast.

Differential expression of LIM domain binding 2 in cancers of the breast.

10.31219/osf.io/2ewxu ◽

2021 ◽

Author(s):

Shahan Mamoor

Keyword(s):

Breast Cancer ◽

Differential Expression ◽

Survival Data ◽

Molecular Subtype ◽

Normal Breast ◽

Lim Domain ◽

Breast cancer affects women at relatively high frequency (1). We mined published microarray datasets (2, 3) to determine in an unbiased fashion and at the systems level genes most differentially expressed in the primary tumors of patients with breast cancer. We report here significant differential expression of the gene encoding LIM domain binding 2, LDB2, when comparing primary tumors of the breast to the tissue of origin, the normal breast. LDB2 mRNA was present at significantly lower quantities in tumors of the breast as compared to normal breast tissue. Analysis of human survival data revealed that expression of LDB2 in primary tumors of the breast was correlated with recurrence-free survival in patients with luminal A subtype cancers, demonstrating a relationship between primary tumor expression of a differentially expressed gene and patient survival outcomes influenced by molecular subtype. LDB2 may be of relevance to initiation, maintenance or progression of cancers of the female breast.

Differential expression of Rho GTPase-activating protein 20 in cancers of the breast.

10.31219/osf.io/q3pf2 ◽

2021 ◽

Author(s):

Shahan Mamoor

Keyword(s):

Breast Cancer ◽

Differential Expression ◽

Survival Data ◽

Rho Gtpase ◽

Normal Breast ◽

Gtpase Activating Protein ◽

Breast cancer affects women at relatively high frequency (1). We mined published microarray datasets (2, 3) to determine in an unbiased fashion and at the systems level genes most differentially expressed in the primary tumors of patients with breast cancer. We report here significant differential expression of the gene encoding Rho GTPase-activating protein 20, ARHGAP20, when comparing primary tumors of the breast to the tissue of origin, the normal breast. ARHGAP20 mRNA was present at significantly lower quantities in tumors of the breast as compared to normal breast tissue. Analysis of human survival data revealed that expression of ARHGAP20 in primary tumors of the breast was correlated with overall survival in patients with HER2+ subtype cancer, demonstrating a relationship between primary tumor expression of a differentially expressed gene and patient survival outcomes influenced by PAM50 molecular subtype. ARHGAP20 may be of relevance to initiation, maintenance or progression of cancers of the female breast.

Differential expression of CKS2 in cancers of the breast.

10.31219/osf.io/zdhr3 ◽

2021 ◽

Author(s):

Shahan Mamoor

Keyword(s):

Breast Cancer ◽

Differential Expression ◽

Survival Data ◽

Normal Breast ◽

Regulatory Subunit ◽

Luminal A ◽

Gene Encoding ◽

Breast cancer affects women at relatively high frequency (1). We mined published microarray datasets (2, 3) to determine in an unbiased fashion and at the systems level genes most differentially expressed in the primary tumors of patients with breast cancer. We report here significant differential expression of the gene encoding the CDC28 protein kinase regulatory subunit 2, CKS2, when comparing primary tumors of the breast to the tissue of origin, the normal breast. CKS2 was also differentially expressed in the tumor cells of patients with triple negative breast cancer. CKS2 mRNA was present at significantly higher quantities in tumors of the breast as compared to normal breast tissue. Analysis of human survival data revealed that expression of CKS2 in primary tumors of the breast was correlated with overall survival in patients with basal and luminal A subtype cancer, but in a contrary manner. CKS2 may be of relevance to initiation, maintenance or progression of cancers of the female breast.

Differential expression of mab-21 like 1 in cancers of the breast.

10.31219/osf.io/2gkba ◽

2021 ◽

Author(s):

Shahan Mamoor

Keyword(s):

Breast Cancer ◽

Differential Expression ◽

Survival Data ◽

Molecular Subtype ◽

Normal Breast ◽

Luminal A ◽

Breast cancer affects women at relatively high frequency (1). We mined published microarray datasets (2, 3) to determine in an unbiased fashion and at the systems level genes most differentially expressed in the primary tumors of patients with breast cancer. We report here significant differential expression of the gene encoding mab-21 like 1, MAB21L1, when comparing primary tumors of the breast to the tissue of origin, the normal breast. MAB21L1 was also differentially expressed in the tumor cells of patients with triple negative breast cancer. MAB21L1 mRNA was present at significantly lower quantities in tumors of the breast as compared to normal breast tissue. Analysis of human survival data revealed that expression of MAB21L1 in primary tumors of the breast was correlated with overall survival in patients with luminal A subtype cancer, demonstrating a relationship between primary tumor expression of a differentially expressed gene and patient survival outcomes influenced by molecular subtype. MAB21L1 may be of relevance to initiation, maintenance or progression of cancers of the female breast.

Differential expression of dCTP pyrophosphatase 1 in cancers of the breast.

10.31219/osf.io/6qphv ◽

2021 ◽

Author(s):

Shahan Mamoor

Keyword(s):

Breast Cancer ◽

Differential Expression ◽

Survival Data ◽

Normal Breast ◽

Tissue Analysis ◽

Gene Encoding ◽

Primary Tumors ◽

Microarray Datasets

Breast cancer affects women at relatively high frequency (1). We mined published microarray datasets (2, 3) to determine in an unbiased fashion and at the systems level genes most differentially expressed in the primary tumors of patients with breast cancer. We report here significant differential expression of the gene encoding dCTP pyrophosphatase 1, DCTPP1, when comparing primary tumors of the breast to the tissue of origin, the normal breast. DCTPP1 was also differentially expressed in the tumor cells of patients with triple negative breast cancer. DCTPP1 mRNA was present at significantly higher quantities in tumors of the breast as compared to normal breast tissue. Analysis of human survival data revealed that expression of DCTPP1 in primary tumors of the breast was correlated with overall survival in patients with basal subtype cancer. DCTPP1 may be of relevance to initiation, maintenance or progression of cancers of the female breast.

Differential expression of TUFT1 in cancers of the breast.

10.31219/osf.io/3rk7f ◽

2021 ◽

Author(s):

Shahan Mamoor

Keyword(s):

Breast Cancer ◽

Differential Expression ◽

Survival Data ◽

Normal Breast ◽

Luminal A ◽

Gene Encoding ◽

Primary Tumors ◽

Microarray Datasets

Breast cancer affects women at relatively high frequency (1). We mined published microarray datasets (2, 3) to determine in an unbiased fashion and at the systems level genes most differentially expressed in the primary tumors of patients with breast cancer. We report here significant differential expression of the gene encoding the tuftelin 1, TUFT1, when comparing primary tumors of the breast to the tissue of origin, the normal breast. TUFT1 was also differentially expressed in the tumor cells of patients with triple negative breast cancer. TUFT1 mRNA was present at significantly higher quantities in tumors of the breast as compared to normal breast tissue. Analysis of human survival data revealed that expression of TUFT1 in primary tumors of the breast was correlated with distant metastasis-free survival in patients with basal and luminal A subtype cancer. TUFT1 may be of relevance to initiation, maintenance or progression of cancers of the female breast.

Differential expression of betaine--homocysteine S-methyltransferase 2 in cancers of the breast.

10.31219/osf.io/ac3v2 ◽

2021 ◽

Author(s):

Shahan Mamoor

Keyword(s):

Breast Cancer ◽

Differential Expression ◽

Survival Data ◽

Molecular Subtype ◽

Normal Breast ◽

Primary Tumors ◽

Luminal B

Breast cancer affects women at relatively high frequency (1). We mined published microarray datasets (2, 3) to determine in an unbiased fashion and at the systems level genes most differentially expressed in the primary tumors of patients with breast cancer. We report here significant differential expression of the gene encoding betaine--homocysteine S-methyltransferase 2, BHMT2, when comparing primary tumors of the breast to the tissue of origin, the normal breast. BHMT2 mRNA was present at significantly lower quantities in tumors of the breast as compared to normal breast tissue. Analysis of human survival data revealed that expression of BHMT2 in primary tumors of the breast was correlated with distant metastasis-free survival in patients with luminal B subtype cancer, demonstrating a relationship between primary tumor expression of a differentially expressed gene and patient survival outcomes influenced by PAM50 molecular subtype. BHMT2 may be of relevance to initiation, maintenance or progression of cancers of the female breast.