Human Papillomavirus (HPV) Testing for Normal Cervical Cytology in Low-Risk Women Aged 30-65 Years by Family Physicians

We report two cases of histologically documented pseudoepitheliomatous keratotic and micaceous balanitis in middle-aged male patients, which showed positivity for low-risk serotype human papillomavirus DNA. To our knowledge, only one other case has been documented. Further immunohistochemical proliferative markers were performed and compared to literature findings in penile epithelial proliferations. Evolution to invasive verrucous carcinoma has been associated with absence of HPV DNA. Thus, if confirmed by further studies, HPV testing should be included in pseudoepitheliomatous keratotic and micaceous balanitis assessment to address prognosis, and management.

Download Full-text

Human Papillomavirus (HPV) Testing on Cervical Cytology Specimens

Molecular Diagnostics in Cytopathology ◽

10.1007/978-3-319-97397-5_10 ◽

2018 ◽

pp. 199-221

Author(s):

Ming Guo

Keyword(s):

Human Papillomavirus ◽

Cervical Cytology ◽

Hpv Testing

Download Full-text

Association between human papillomavirus (HPV) DNA and micronuclei in normal cervical cytology

Genetics and Molecular Biology ◽

10.1590/s1415-47572014005000010 ◽

2014 ◽

Vol 37 (2) ◽

pp. 360-363 ◽

Cited By ~ 15

Author(s):

Ana Paula Rebelo Cassel ◽

Regina Bones Barcellos ◽

Cláudia Maria Dornelles da Silva ◽

Sabrina Esteves de Matos Almeida ◽

Maria Lucia Rosa Rossetti

Keyword(s):

Human Papillomavirus ◽

Cervical Cytology ◽

Hpv Dna ◽

Normal Cervical Cytology

Download Full-text

Bethesda 2014 Implementation and Human Papillomavirus Primary Screening: Practices of Laboratories Participating in the College of American Pathologists PAP Education Program

Archives of Pathology & Laboratory Medicine ◽

10.5858/arpa.2018-0603-cp ◽

2019 ◽

Vol 143 (10) ◽

pp. 1196-1202 ◽

Cited By ~ 7

Author(s):

Diane Davis Davey ◽

Rhona J. Souers ◽

Kelly Goodrich ◽

Dina R. Mody ◽

Sana O. Tabbara ◽

...

Keyword(s):

Human Papillomavirus ◽

Education Program ◽

Cervical Cytology ◽

Current Status ◽

Low Grade ◽

Hpv Testing ◽

Squamous Intraepithelial Lesion ◽

Primary Screening ◽

Intraepithelial Lesion ◽

Bethesda System

Context.— Cervical cancer screening laboratory practices may evolve with new terminology and technologies. Objective.— To investigate changes in cervical cytopathology practice resulting from the 2014 Bethesda System updates and screening technologies. Design.— Questionnaires accompanied 2016 and 2017 mailings of the College of American Pathologists PAP Education program. Results.— In 2016, most laboratories surveyed had adopted or were planning to adopt 2014 Bethesda System updates, and the majority (53%; 365 of 689) used an age cutoff of 45 for reporting benign-appearing endometrial cells. However, 51.3% (354 of 690) of laboratories used the term low-grade squamous intraepithelial lesion, cannot exclude high-grade squamous intraepithelial lesion, for cases with indeterminate features, and 44.9% (298 of 664) of laboratories used a 5000-cell cutoff for minimum squamous cellularity for posthysterectomy and posttherapy specimens. Reporting rates for cervical cytology metrics changed very little from 2013 to 2016, and the median ratio of atypical squamous cells to squamous intraepithelial lesion cases was 1.9 for ThinPrep and 1.8 for SurePath preparations. Most laboratories (59.4%; 389 of 655) did not offer stand-alone primary human papillomavirus (HPV) testing in 2017, and primary HPV testing accounted for a low proportion of HPV testing volumes. The Roche Cobas method was the most common platform for HPV primary screening. Conclusions.— These questionnaire surveys provide data about the current status of cervical cytology screening, including changes related to the 2014 Bethesda System updates and the adoption of HPV primary screening techniques.

Download Full-text

GTL001, A Therapeutic Vaccine for Women Infected with Human Papillomavirus 16 or 18 and Normal Cervical Cytology: Results of a Phase I Clinical Trial

Clinical Cancer Research ◽

10.1158/1078-0432.ccr-16-0085 ◽

2016 ◽

Vol 22 (13) ◽

pp. 3238-3248 ◽

Cited By ~ 14

Author(s):

Pierre Van Damme ◽

Myriam Bouillette-Marussig ◽

Annick Hens ◽

Ilse De Coster ◽

Christophe Depuydt ◽

...

Keyword(s):

Clinical Trial ◽

Human Papillomavirus ◽

Phase I ◽

Therapeutic Vaccine ◽

Phase I Clinical Trial ◽

Cervical Cytology ◽

Human Papillomavirus 16 ◽

Normal Cervical Cytology

Download Full-text

Age factor and implication of human papillomavirus type-specific prevalence in women with normal cervical cytology

Epidemiology and Infection ◽

10.1017/s0950268811000720 ◽

2011 ◽

Vol 140 (3) ◽

pp. 466-473 ◽

Cited By ~ 6

Author(s):

C. H. LAI ◽

A. CHAO ◽

C. J. CHANG ◽

C. C. HUANG ◽

L. C. WANG ◽

...

Keyword(s):

Human Papillomavirus ◽

Hormone Replacement ◽

Menopausal Status ◽

Hpv Infection ◽

Population Based ◽

Cervical Cytology ◽

Genotype Distribution ◽

Abnormal Cytology ◽

Normal Cytology ◽

Normal Cervical Cytology

SUMMARYThe prevalence and genotype distribution of human papillomavirus (HPV) infection in women with normal cervical cytology varies widely according to the population studied. Two non-overlapping population-based cohort studies of women aged ⩾30 years for the periods 2008–2009 (n=5026) and 2004–2005 (n=10 014) were analysed. The prevalence rate of HPV was 11·0% (95% CI 10·5–11·6). HPV infection was significantly associated with age, menopausal status, and inversely associated with hormone replacement therapy. There was an increasing trend of α3/α15, α5/α6, and multiple HPV infections with increasing age. The five most common types were HPV52, 18, 53, 58 and 70, while HPV16, 31, 33 ranked 21st, 25th, and 16th, respectively, in the merged cohort with normal cytology (n=14 724). HPV16, 31, and 33 were significantly associated with abnormal cytology, which could have resulted in their rarity in the total merged cohort (n=15 040).

Download Full-text