Cystic and florid squamous metaplasia in pleomorphic adenoma of palate – A diagnostic dilemma

Pleomorphic adenoma is a benign tumor of salivary gland. Controversy regarding the origin of various mesenchymal components exists and myoepithelial cell has a key role. Metaplastic process is triggered by minor trauma and probable etiology for this change is ischemia. It is diagnostically challenging, because diagnostic pit falls in the presence of mucinous and squamous metaplasia. Report a case of pleomorphic adenoma in the palate of a 35 years old Indian female. Biopsy revealed epithelial component with extensive squamous metaplasia and cystic degeneration. Here we discuss the role of myoepithelial cells in the pathogenesis of pleomorphic adenoma and diagnostic pit falls. DOI: http://dx.doi.org/10.3126/ajms.v5i4.10434 Asian Journal of Medical Sciences 2014 Vol.5(4); 108-110

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Malignant Myoepithelial Carcinoma Expleomorphic Adenoma of the Hard Palate: An Aggressive Tumor with Diagnostic Dilemma

International Journal of Head and Neck Surgery ◽

10.5005/jp-journals-10001-1185 ◽

2014 ◽

Vol 5 (2) ◽

pp. 72-77

Author(s):

Sudhir Naik ◽

Rajshekar Halkud ◽

KT Siddappa ◽

Akshay Shivappa ◽

Siddharth Biswas ◽

...

Keyword(s):

Pleomorphic Adenoma ◽

Hard Palate ◽

De Novo ◽

Metastatic Tumor ◽

Myoepithelial Cells ◽

Concurrent Chemotherapy ◽

Adjuvant Chemoradiotherapy ◽

Myoepithelial Carcinoma ◽

Diagnostic Dilemma ◽

Aggressive Tumor

ABSTRACT Background/Objectives Myoepithelial carcinomas are uncommon neoplasms that account for about 10% of all myoepitheliomas. The invasiveness varies from a locally aggressive to highly metastatic tumor which may arise de novo or in a pleomorphic adenoma. Myoepitheliomas arise from myoepithelial cells lacking ductal differentiation which exhibit both epithelial and smooth muscle cell elements. Case report We report a case of palatal swelling excised 4 years back, as pleomorphic adenoma, which later recurred as malignant myoepithelial carcinoma expleomorphic adenoma of the palate. CECT of the paranasal air sinuses did not show any bony invasion of the hard palate. So he was given radical radiotherapy with concurrent chemotherapy but after 3 years developed recurnce and metastasis to the skin and the lungs. The patient was referred to oral chemotherapy on a palliative basis. Conclusion Malignant myoepithelial carcinoma expleomorphic adenoma of the hard palate is a highly aggressive rare tumor of the hard palate. Radical management with surgery and adjuvant chemoradiotherapy improves survival in these patients. Followup with metastatic workup should be accurate as the tumor is highly aggressive with poor prognosis. How to cite this article Shenoy AM, Halkud R, Shivappa A, Chavan p, Sunil KC, Sarvadyna J, Samskruthi M, Siddappa KT, Biswas S, Naik SM. Malignant Myoepithelial Carcinoma Expleomorphic Adenoma of the Hard palate: An Aggressive Tumor with Diagnostic Dilemma. Int J Head Neck Surg 2014;5(2):72-77.

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The role of FGF-2/HGF and fibronectin matrix on pleomorphic adenoma myoepithelial cell morphology and immunophenotype: anin vitrostudy

Growth Factors ◽

10.3109/08977194.2014.957758 ◽

2014 ◽

Vol 33 (1) ◽

pp. 50-56

Author(s):

Carolina Amália Barcellos Silva ◽

Laura Cristina Leite Nardello ◽

Frederico Windlin Garcia ◽

Ney Soares de Araújo ◽

Victor Angelo Montalli ◽

...

Keyword(s):

Pleomorphic Adenoma ◽

Cell Morphology ◽

Myoepithelial Cell ◽

Fibronectin Matrix

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Myoepithelial cells are a dynamic barrier to epithelial dissemination

The Journal of Cell Biology ◽

10.1083/jcb.201802144 ◽

2018 ◽

Vol 217 (10) ◽

pp. 3368-3381 ◽

Cited By ~ 25

Author(s):

Orit Katarina Sirka ◽

Eliah R. Shamir ◽

Andrew J. Ewald

Keyword(s):

Smooth Muscle ◽

Cancer Cells ◽

Barrier Function ◽

Myoepithelial Cell ◽

Smooth Muscle Actin ◽

Myoepithelial Cells ◽

Escape Time ◽

Specific Expression ◽

Twist1 Expression

The mammary epithelium is composed of an inner luminal and surrounding myoepithelial cell layer. The presence of cancer cells beyond the myoepithelium defines invasive breast cancer, yet the role of the myoepithelium during invasion remains unclear. We developed a 3D organotypic culture assay to model this process through lineage-specific expression of the prometastatic transcription factor Twist1. We sought to distinguish the functional role of the myoepithelium in regulating invasion and local dissemination. Myoepithelial-specific Twist1 expression induced cell-autonomous myoepithelial cell escape. Remarkably, luminal-specific Twist1 expression was rarely sufficient for escape. Time-lapse microscopy revealed that myoepithelial cells collectively restrain and reinternalize invading Twist1+ luminal cells. Barrier function correlated with myoepithelial abundance and required the expression of α-smooth muscle actin and P-cadherin. We next demonstrated that myoepithelial cells can restrain and recapture invasive cancer cells. Our data establish the concept of the myoepithelium as a dynamic barrier to luminal dissemination and implicate both smooth muscle contractility and intercellular adhesion in barrier function.

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Histogenesis of salivary gland pleomorphic adenoma (mixed tumor) with an evaluation of the role of the myoepithelial cell

Human Pathology ◽

10.1016/s0046-8177(82)80140-8 ◽

1982 ◽

Vol 13 (1) ◽

pp. 62-75 ◽

Cited By ~ 127

Author(s):

Irving Dardick ◽

A.W. Peter van Nostrand ◽

M. James Phillips

Keyword(s):

Salivary Gland ◽

Pleomorphic Adenoma ◽

Myoepithelial Cell ◽

Mixed Tumor

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Pleomorphic Adenoma of the Breast

Archives of Pathology & Laboratory Medicine ◽

10.5858/2003-127-0474-paotb ◽

2003 ◽

Vol 127 (4) ◽

pp. 474-477

Author(s):

M. Reid-Nicholson ◽

I. Bleiweiss ◽

B. Pace ◽

V. Azueta ◽

S. Jaffer

Keyword(s):

Postmenopausal Women ◽

Pleomorphic Adenoma ◽

Benign Tumor ◽

Invasive Carcinoma ◽

Mucinous Carcinoma ◽

Myoepithelial Cells ◽

Histologic Appearance ◽

Rare Benign Tumor

Abstract Pleomorphic adenoma of the breast is a rare, benign tumor accounting for 68 cases in the literature. It is most commonly seen in postmenopausal women and is characterized by an admixture of epithelial and myoepithelial cells embedded in abundant myxomatous stroma. Its clinical and histologic appearance can be challenging and may lead to a misdiagnosis of invasive carcinoma. We report a case of mammary pleomorphic adenoma in an asymptomatic 59-year-old woman and briefly discuss its distinction from mucinous carcinoma through the use of special stains.

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Management of Basal Cell Adenoma of Accessory Parotid Gland Through Transoral Approach: Report of a Rare Case With Review

Craniomaxillofacial Trauma & Reconstruction Open ◽

10.1177/24727512211030839 ◽

2021 ◽

Vol 6 ◽

pp. 247275122110308

Author(s):

Charudatta Naik ◽

Sanjay Joshi ◽

Bhupendra Mhatre ◽

Sneha Punamiya

Keyword(s):

Parotid Gland ◽

Basal Cell ◽

Benign Tumor ◽

Transoral Approach ◽

Surgical Approaches ◽

Basal Cell Adenoma ◽

Diagnostic Dilemma ◽

Cell Adenoma ◽

Rare Benign Tumor ◽

Accessory Parotid Gland

Diagnosis of mid-cheek mass has always been a diagnostic dilemma for clinicians. The incidence of the accessory parotid gland (APG) has been well documented in the literature. However, a diverse spectrum of pathologies can arise from this accessory parotid tissue. Basal cell adenoma is a rare benign tumor that predominantly affects the parotid gland. Its occurrence in the accessory parotid gland has been documented in 9 cases till date. Surgical approaches for the management of such APG lesions have been in debate. This report documents a case of Basal Cell Adenoma arising in accessory parotid tissue in a 55-year-old woman who was treated by transoral excision. This paper also reviews previously documented cases of all APG lesions and attempts to elucidate the rationale for selecting an appropriate surgical approach.

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The role of trans obturator tape as a surgical procedure for female stress urinary incontinence and its impact on quality of life in Jammu region

International Journal of Reproduction Contraception Obstetrics and Gynecology ◽

10.18203/2320-1770.ijrcog20195355 ◽

2019 ◽

Vol 8 (12) ◽

pp. 4975

Author(s):

Sapna Puri ◽

Manisha Kohli

Keyword(s):

Quality Of Life ◽

Stress Incontinence ◽

Symptomatic Relief ◽

Female Stress Urinary Incontinence ◽

Medical Sciences ◽

King’S Health Questionnaire ◽

Promising Treatment ◽

Pre Treatment

Background: Stress incontinence is one of the most common but debilitating health issue among women. It has a detrimental effect on overall health and quality of life of women. Trans obturator tape (TOT) has emerged as a promising treatment modality. The aim of present study was to assess the usefulness of TOT in terms of change in quality of life of stress incontinence patients.Methods: The study was performed at Department of Obstetrics and Gynecology, Acharya Shri Chandler of Medical Sciences (ASCOMS), Jammu. A total of 50 symptomatic women were enrolled in the study and underwent TOT procedure using outside-in technique. The quality of life of women was assessed at enrolment and 12 months after the procedure using King’s Health Questionnaire (KHQ). Change in QOL was assessed using paired ‘t’-test.Results: After 12 months follow-up, a total of 27 (54%) patients were entirely symptom free. As compared to pre-treatment QOL assessment on KHQ for general health/incontinence impact, quality of life and symptom scores a % decline of 73.2%, 79.8% and 78.4% was observed. For all the three parts, the change in scores was significant statistically. No other complications and side effects were reported.Conclusions: TOT is a useful procedure which provided symptomatic relief as well as QOL enhancement.

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