scholarly journals Phthisis Bulbi and Leptomeningeal Metastasis in a Case of Trilateral Retinoblastoma

2014 ◽  
Vol 3 (2) ◽  
pp. 92-96
Author(s):  
MK Gupta ◽  
RK Rauniyar ◽  
K Ahmad ◽  
AR Pant ◽  
A Kumar ◽  
...  
Keyword(s):  
Optic Nerve ◽  
Subarachnoid Space ◽  
Primitive Neuroectodermal Tumor ◽  
Malignant Neoplasm ◽  
Leptomeningeal Metastasis ◽  
Pineal Region ◽  
Neuroectodermal Tumor ◽  
Uncommon Presentation ◽  
Trilateral Retinoblastoma ◽  
Phthisis Bulbi

Retinoblastoma (RB) is the most common ocular malignant neoplasm of childhood. Bilateral or unilateral intraocular RB in conjunction with a primitive neuroectodermal tumor (PNET) of the pineal region (i.e. pineoblastoma) is termed as trilateral retinoblastoma (TRB). Retinoblastoma may spread along the optic nerve to the intracranial compartment to give drop metastases in the subarachnoid space or it can spread through hematogenous and lymphatic routes. Phthisis bulbi (PB) is a relatively uncommon presentation of retinoblastoma. We report a case of trilateral retinoblastoma with phthisical left eye and extensive leptomeningeal metastasis in a 3-year-old female child.DOI: http://dx.doi.org/10.3126/njr.v3i2.9621   Nepalese Journal of Radiology Vol.3(2)July-Dec, 2013: 92-96 

Primitive neuroectodermal tumor in the jaw: report of a case

2005 ◽  
Vol 28 (2) ◽  
pp. 167-171
Author(s):  
Toranzo Fernández José Martin ◽  
Salgado-García Nickte-ha ◽  
Santos-Díaz Miguel Ángel
Keyword(s):  
Neural Crest ◽  
Head And Neck ◽  
Primitive Neuroectodermal Tumor ◽  
Malignant Neoplasm ◽  
Stage Iv ◽  
Tumor Stage ◽  
Neuroectodermal Tumor ◽  
Mexican Patient

The neuroectodermal tumor is a malignant neoplasm of round cells originated from the neural crest. The occurrence of this tumor in head and neck is rare.A 5 month old Mexican patient with a primitive neuroectodermic tumor stage IV, in the jaw is reported.

scholarly journals Anti-PD-1 Immunotherapy Combined With Antiangiogenic Therapy as Salvage Therapy in a Patient With Refractory Metastatic Peripheral Primitive Neuroectodermal Tumor: A Case Report and Literature Review

2021 ◽  
Author(s):  
Qiaoyun Chen ◽  
Ronghui Jin ◽  
Xu Li ◽  
Qifan Wu ◽  
Gaili An
Keyword(s):  
Primitive Neuroectodermal Tumor ◽  
Kinase Inhibitor ◽  
Treatment Plan ◽  
Antiangiogenic Therapy ◽  
Malignant Neoplasm ◽  
Neuroectodermal Tumor ◽  
Comprehensive Treatment ◽  
Peripheral Primitive Neuroectodermal Tumor ◽  
New Ideas ◽  
The Right

Abstract Background: Peripheral primitive neuroectodermal tumor (pPNET) is a relatively rare malignant neoplasm that usually occurs in children and young adults,associated with poor prognosis. However, standard treatment for refractory pPNET has not been determined.Case presentation: A case of a 38-year-old woman with pPNET on the right shoulder and back,she had gained up to seven-and-a-half years suvival undergoing these comprehensive treatment including surgery, radiotherapy, chemotherapy, antiangiogenic treatment. However, the tumor eventually progressed after receiving multiline treatment.With the patient's strong desire to receive immunotherapy, we finally adjusted the treatment plan to " anti-angiogenic tyrosine kinase inhibitor Lenvatinib combined with PD-1 inhibitor Toripalimab" for 2 cycles.Unfortunately,she developed grade 2-3 immune pneumonia after treatment.Conclusions: To our knowledge, this is the first report of immunotherapy combined with antiangiogenic therapy in pPNET,which provides new ideas for the treatment of refractory pPNET.

Uncommon Presentation of Rare Disorder—Duodenal Ulcer Secondary to Invasive Pancreatic Primitive Neuroectodermal Tumor

2011 ◽  
Vol 33 (7) ◽  
pp. 543-548 ◽  
Author(s):  
Laura Maxwell ◽  
April Hederman ◽  
Courtney Jackson ◽  
David Sawaya ◽  
Henry Giles ◽  
...  
Keyword(s):  
Duodenal Ulcer ◽  
Primitive Neuroectodermal Tumor ◽  
Neuroectodermal Tumor ◽  
Rare Disorder ◽  
Uncommon Presentation

Constitutional t(16;22)(p13.3;q11.2∼12) in a primitive neuroectodermal tumor of the pineal region

2003 ◽  
Vol 142 (1) ◽  
pp. 73-76 ◽  
Author(s):  
Jeffrey R. Sawyer ◽  
Gael Sammartino ◽  
Muhammad Husain ◽  
Mark E. Linskey
Keyword(s):  
Primitive Neuroectodermal Tumor ◽  
Pineal Region ◽  
Neuroectodermal Tumor

Cutaneous angiosarcoma as a second malignant neoplasm after peripheral primitive neuroectodermal tumor

1992 ◽  
Vol 20 (4) ◽  
pp. 352-356 ◽  
Author(s):  
Cheryl M. Coffin ◽  
Teresa J. Vietti ◽  
Vita J. Land ◽  
William G. Kraybill ◽  
Louis P. Dehner
Keyword(s):  
Primitive Neuroectodermal Tumor ◽  
Malignant Neoplasm ◽  
Neuroectodermal Tumor ◽  
Peripheral Primitive Neuroectodermal Tumor ◽  
Second Malignant Neoplasm

Membranous alterations in the cytoplasm and nucleus in a primitive neuroectodermal tumor of the brain

1978 ◽  
Vol 36 (2) ◽  
pp. 628-629
Author(s):  
C. N. Sun ◽  
C. Araoz ◽  
H. J. White
Keyword(s):  
Nuclear Envelope ◽  
Tumor Cells ◽  
Osmium Tetroxide ◽  
Primitive Neuroectodermal Tumor ◽  
Uranyl Acetate ◽  
Neuroectodermal Tumor ◽  
Annulate Lamellae ◽  
Lead Citrate ◽  
Thin Sections ◽  
The Brain

The ultrastructure of a cerebral primitive neuroectodermal tumor has been reported previously. In the present case, we will present some unusual previously unreported membranous structures and alterations in the cytoplasm and nucleus of the tumor cells.Specimens were cut into small pieces about 1 mm3 and immediately fixed in 4% glutaraldehyde in phosphate buffer for two hours, then post-fixed in 1% buffered osmium tetroxide for one hour. After dehydration, tissues were embedded in Epon 812. Thin sections were stained with uranyl acetate and lead citrate.In the cytoplasm of the tumor cells, we found paired cisternae (Fig. 1) and annulate lamellae (Fig. 2) noting that the annulate lamellae were sometimes associated with the outer nuclear envelope (Fig. 3). These membranous structures have been reported in other tumor cells. In our case, mitochondrial to nuclear envelope fusions were often noted (Fig. 4). Although this phenomenon was reported in an oncocytoma, their frequency in the present study is quite striking.

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