scholarly journals Correlation Between Age, Body Mass Index, And Blood Selenium Level with Glutathione Peroxidase Activity Among Elderly in South Jakarta

2020 ◽  
Vol 4 (2) ◽  
pp. 89
Author(s):  
Annisa Nurul Kirana ◽  
Erfi Prafiantini ◽  
Novi Silvia Hardiany
Keyword(s):  
Body Mass Index ◽  
Glutathione Peroxidase ◽  
Body Mass ◽  
Peroxidase Activity ◽  
Selenium Level ◽  
Glutathione Peroxidase Activity ◽  
Cross Sectional ◽  
Plasma Glutathione Peroxidase ◽  
Plasma Glutathione ◽  
Nonparametric Correlation

Oxidative stress contributed in aging process and several degenerative diseases. Selenium was an important trace element due to as a component of antioxidants enzymes (selenoproteins), including glutathione peroxidase for protection against free radical.Objective: We aimed to study the correlation between blood selenium level and plasma glutathione peroxidase activity in elderly.Materials and Methods: Cross sectional study was held in 5 elderly communities in south Jakarta. Body mass index, blood selenium level and plasma glutathione peroxidase activity were measured in 95 elderly aged between 60-86 years old. Nonparametric correlation was used for correlation analysis.Results and Discussion: The median of subject’s age was 69 years old (60-86) and for body mass index was 23.57 (13.59-36.05). The median of selenium level among subject was 0.19 (0.023-0.56). The mean of plasma glutathione peroxidase activity was 164.45 U/L ± 68.07. There was no correlation among variables. However, plasma glutathione peroxidase activity decreased with increasing age and body mass index although it was not significant.Conclusion: There was no correlation between blood selenium level and plasma glutathione peroxidase activity. Detection of plasma selenium level is needed to confirm this result.International Journal of Human and Health Sciences Vol. 04 No. 02 April’20 Page : 89-93

Plasma Glutathione Peroxidase Activity in Preeclampsia

1988 ◽  
Vol 75 (s19) ◽  
pp. 43P-43P
Author(s):  
R.M. Berry ◽  
N.A. Punchard ◽  
N.A. MacLachlan ◽  
R.P.H. Thompson
Keyword(s):  
Glutathione Peroxidase ◽  
Peroxidase Activity ◽  
Glutathione Peroxidase Activity ◽  
Plasma Glutathione Peroxidase ◽  
Plasma Glutathione

Determination of selenium concentration and glutathione peroxidase activity in plasma and erythrocytes.

1982 ◽  
Vol 28 (2) ◽  
pp. 311-316 ◽  
Author(s):  
P A Pleban ◽  
A Munyani ◽  
J Beachum
Keyword(s):  
Glutathione Peroxidase ◽  
Peroxidase Activity ◽  
Zeeman Effect ◽  
Selenium Concentration ◽  
Glutathione Peroxidase Activity ◽  
Plasma Selenium ◽  
Plasma Glutathione Peroxidase ◽  
Flameless Atomic Absorption Spectroscopy ◽  
Plasma Glutathione

Abstract We determined selenium concentrations and activities of the selenoenzyme, glutathione peroxidase (EC 1.11.1.9), in the plasma and erythrocytes of 38 apparently healthy women. We determined selenium concentrations directly by polarized Zeeman-effect flameless atomic absorption spectroscopy. Within-run precision studies for the assays gave CVs of 5.6% for a mean erythrocyte selenium concentration of 149.9 (SD 8.3) microgram/L (n = 10) and 6.4% for a mean plasma selenium concentration of 97.3 (SD 6.2) microgram/L (n = 12). For the women, mean selenium concentrations were 141.4 (SD 14.3) microgram/L of erythrocytes [0.49 (SD 0.07) microgram/g of hemoglobin and 96.3 (SD 14.2) microgram/L of plasma. Glutathione peroxidase activities were measured by a modification of the method of Paglia and Valentine (J. Lab. Clin. Med. 70: 158--169, 1967). Within-run precision studies for the glutathione peroxidase assays gave CVs of 12.8% for mean erythrocyte glutathione peroxidase activity of 77.2 (SD 9.9) U/g of hemoglobin (n = 13), and 8.1% for mean plasma activity of 312.5 (SD 25.2) U/L (n = 11). Mean enzyme activity was 78.7 (SD 12.9) U/g of hemoglobin for erythrocytes and 424 (SD 40) U/L for plasma. Erythrocyte selenium concentrations and glutathione peroxidase activities were positively, but poorly, correlated (r = 0.41, p less than 0.01).

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