scholarly journals Inhibitory Effects of Allium Vegetable Extracts on Fatty Acid Synthase

2009 ◽  
Vol 15 (3) ◽  
pp. 343-346 ◽  
Author(s):  
Xue-Bing SUN ◽  
Wei-Xi TIAN
Keyword(s):  
Fatty Acid ◽  
Fatty Acid Synthase ◽  
Inhibitory Effects

scholarly journals Inhibitory effects of garcinone E on fatty acid synthase

RSC Advances ◽  
2018 ◽  
Vol 8 (15) ◽  
pp. 8112-8117 ◽  
Author(s):  
Yan Liang ◽  
Di Luo ◽  
Xuan Gao ◽  
Hao Wu
Keyword(s):  
Fatty Acid ◽  
Fatty Acid Synthase ◽  
Time Dependent ◽  
Inhibitory Effects ◽  
Irreversible Inhibition

Garcinone E exhibits both fast-binding reversible and time-dependent irreversible inhibition on the activity of fatty acid synthase.

Inhibitory effects of sea buckthorn procyanidins on fatty acid synthase and MDA-MB-231 cells

Tumor Biology ◽  
2014 ◽  
Vol 35 (10) ◽  
pp. 9563-9569 ◽  
Author(s):  
Yi Wang ◽  
Fangyuan Nie ◽  
Jian Ouyang ◽  
Xiaoyan Wang ◽  
Xiaofeng Ma
Keyword(s):  
Fatty Acid ◽  
Fatty Acid Synthase ◽  
Sea Buckthorn ◽  
Inhibitory Effects

scholarly journals Inhibitory effects of thioethers on fatty acid synthase and 3T3-L1 cells

2009 ◽  
Vol 25 (2) ◽  
pp. 290-295 ◽  
Author(s):  
Xue-Bing Sun ◽  
Jiong Zhao ◽  
Xiao-Feng Ma ◽  
Wei-Xi Tian
Keyword(s):  
Fatty Acid ◽  
Fatty Acid Synthase ◽  
Inhibitory Effects

scholarly journals Aster glehni F. Schmidt Extract Modulates the Activities of HMG-CoA Reductase and Fatty Acid Synthase

Plants ◽  
2021 ◽  
Vol 10 (11) ◽  
pp. 2287
Author(s):  
Hyunbeom Lee ◽  
Hyoung Ja Kim ◽  
Hyungi Chae ◽  
Na Eun Yoon ◽  
Byung Hwa Jung
Keyword(s):  
Fatty Acid ◽  
Fatty Acid Synthase ◽  
Therapeutic Potential ◽  
Methyl Esters ◽  
Acid Synthesis ◽  
Inhibitory Effect ◽  
Lipid Lowering ◽  
Inhibitory Effects ◽  
Hmg Coa Reductase ◽  
Coa Reductase

Aster glehni F. Schmidt (AG), is a natural product known to have anti-obesity effects, but the mechanism underlying these effects is not well documented. We hypothesized that AG may have inhibitory effects on enzymes related to lipid accumulation. Herein, AG fractions were tested against HMG-CoA reductase (HMGR) and fatty acid synthase (FAS), two important enzymes involved in cholesterol and fatty acid synthesis, respectively. We found that dicaffeoylquinic acid (DCQA) methyl esters present in AG are largely responsible for the inhibition of HMGR and FAS. Since free DCQA is a major form present in AG, we demonstrated that a simple methylation of the AG extract could increase the overall inhibitory effects against those enzymes. Through this simple process, we were able to increase the inhibitory effect by 150%. We believe that our processed AG effectively modulates the HMGR and FAS activities, providing promising therapeutic potential for cholesterol- and lipid-lowering effects.

scholarly journals Inhibitory Effects of 4-(4-Methylbenzamino)benzoate on Adipocyte Differentiation

2015 ◽  
Vol 2015 ◽  
pp. 1-4
Author(s):  
Jin Taek Hwang ◽  
Sanghee Kim ◽  
Bo-ra Yoon ◽  
Inwook Choi ◽  
Sang Yoon Choi
Keyword(s):  
Fatty Acid ◽  
Glucose Metabolism ◽  
Fatty Acid Synthase ◽  
Adipocyte Differentiation ◽  
Ppar Gamma ◽  
Gamma Activity ◽  
Dependent Manner ◽  
Inhibitory Effects ◽  
Concentration Dependent Manner ◽  
Cellular Expression

The potent suppression of adipocyte differentiation by 4-(4-methylbenzamino)benzoate was discovered during the search for new antiobesity compounds. 4-(4-methylbenzamino)benzoate was observed to suppress adipocyte differentiation in 3T3-L1 cells by 96.8% at 50 μM without cytotoxicity. In addition, 4-(4-methylbenzamino)benzoate reduced the cellular expression of fatty acid synthase in a concentration-dependent manner, as well as suppressing PPAR-gamma activity, which controls fatty acid storage and glucose metabolism. Based on these results, 4-(4-methylbenzamino)benzoate shows potential as an antiobesity material.

Inhibitory effects of four plants flavonoids extracts on fatty acid synthase

2009 ◽  
Vol 21 ◽  
pp. S131-S134 ◽  
Author(s):  
Jun CHEN ◽  
Donghong ZHUANG ◽  
Weijia CAI ◽  
Liyan XU ◽  
Enmin LI ◽  
...  
Keyword(s):  
Fatty Acid ◽  
Fatty Acid Synthase ◽  
Inhibitory Effects
Sign in / Sign up

Export Citation Format

Share Document