Orphan designation: apraglutide, Treatment of short bowel syndrome

2019 ◽  
Author(s):  
Keyword(s):  
Short Bowel Syndrome ◽  
Short Bowel ◽  
Orphan Designation

PARENTERAL NUTRITION WITH OMEGA-3 FATTY ACIDS RESULTS IN HIGH ENDOGENOUS EPA/DHA LEVELS IN SHORT BOWEL SYNDROME PATIENTS

2017 ◽  
Author(s):  
M Karber ◽  
S Pevny ◽  
D Thurmann ◽  
WH Schunck ◽  
KH Weylandt ◽  
...  
Keyword(s):  
Fatty Acids ◽  
Parenteral Nutrition ◽  
Short Bowel Syndrome ◽  
Omega 3 Fatty Acids ◽  
Omega 3 ◽  
Short Bowel

Short bowel syndrome after Billroth II gastric resection

2004 ◽  
Vol 42 (05) ◽  
Author(s):  
Z Nagy ◽  
A Illés ◽  
Á Király ◽  
L Nagy
Keyword(s):  
Short Bowel Syndrome ◽  
Gastric Resection ◽  
Billroth Ii ◽  
Short Bowel

Achievements and realities of surgical treatment for short bowel syndrome (literature review)

2018 ◽  
Vol 0 (8.87) ◽  
pp. 15-21
Author(s):  
B.I. Slonetsky ◽  
M.I. Tutchenko ◽  
I.V. Verbitsky
Keyword(s):  
Surgical Treatment ◽  
Literature Review ◽  
Short Bowel Syndrome ◽  
Short Bowel

scholarly journals Biodistribution of the radiophamarceutical sodium pertechnetate (Na99mTcO4) after massive small bowel resection in rats

2007 ◽  
Vol 22 (6) ◽  
pp. 430-435 ◽  
Author(s):  
Dâmaso de Araújo Chacon ◽  
Irami Araújo-Filho ◽  
Arthur Villarim-Neto ◽  
Amália Cínthia Meneses Rêgo ◽  
Ítalo Medeiros Azevedo ◽  
...  
Keyword(s):  
Small Intestine ◽  
Short Bowel Syndrome ◽  
Intestinal Mucosa ◽  
Intestinal Resection ◽  
Small Bowel Resection ◽  
Control Group ◽  
Short Bowel ◽  
Massive Resection ◽  
Mucosal Thickness ◽  
Misleading Interpretation

PURPOSE: To evaluate the biodistribution of sodium pertecnetate (Na99mTcO4) in organs and tissues, the morphometry of remnant intestinal mucosa and ponderal evolution in rats subjected to massive resection of the small intestine. METHODS: Twenty-one Wistar rats were randomly divided into three groups of 7 animals each. The short bowel (SB) group was subjected to massive resection of the small intestine; the control group (C) rats were not operated on, and soft intestinal handling was performed in sham rats. The animals were weighed weekly. On the 30th postoperative day, 0.l mL of Na99mTcO4, with mean activity of 0.66 MBq was injected intravenously into the orbital plexus. After 30 minutes, the rats were killed with an overdose of anesthetic, and fragments of the liver, spleen, pancreas, stomach, duodenum, small intestine, thyroid, lung, heart, kidney, bladder, muscle, femur and brain were harvested. The biopsies were washed with 0.9% NaCl.,The radioactivity was counted using Gama Counter WizardTM 1470, PerkinElmer. The percentage of radioactivity per gram of tissue (%ATI/g) was calculated. Biopsies of the remaining jejunum were analysed by HE staining to obtain mucosal thickness. Analysis of variance (ANOVA) and the Tukey test for multiple comparisons were used, considering p<0.05 as significant. RESULTS: There were no significant differences in %ATI/g of the Na99mTcO4 in the organs of the groups studied (p>0.05). An increase in the weight of the SB rats was observed after the second postoperative week. The jejunal mucosal thickness of the SB rats was significantly greater than that of C and sham rats (p<0.05). CONCLUSION: In rats with experimentally-produced short bowel syndrome, an adaptive response by the intestinal mucosa reduced weight loss. The biodistribution of Na99mTcO4 was not affected by massive intestinal resection, suggesting that short bowel syndrome is not the cause of misleading interpretation, if an examination using this radiopharmaceutical is indicated.

Sign in / Sign up

Export Citation Format

Share Document