Effect of Food and Calcium on Pharmacokinetics of a Single Dose of S-888711 in Healthy Adult Volunteers

2019 ◽  
Author(s):  
Keyword(s):  
Single Dose ◽  
Healthy Adult ◽  
Effect Of Food ◽  
Adult Volunteers

The Single-Dose Pharmacokinetics of Clopidogrel in Healthy Adult Volunteers

2003 ◽  
Vol 73 (2) ◽  
pp. P47-P47
Author(s):  
J. Grenier ◽  
S. Ciric ◽  
J. Curry ◽  
G. Morelli ◽  
A. Arseneault ◽  
...  
Keyword(s):  
Single Dose ◽  
Healthy Adult ◽  
Adult Volunteers

The Absence of a Clinically Significant Effect of Food on the Single Dose Pharmacokinetics of Vorapaxar, a PAR-1 Antagonist, in Healthy Adult Subjects

2013 ◽  
Vol 2 (4) ◽  
pp. 310-315 ◽  
Author(s):  
Martin O. Behm ◽  
Teddy Kosoglou ◽  
André M.M. Miltenburg ◽  
Jing Li ◽  
Paul Statkevich ◽  
...  
Keyword(s):  
Single Dose ◽  
Healthy Adult ◽  
Effect Of Food ◽  
Clinically Significant

Influence of Enteral Feedings on Phenytoin Sodium Absorption from Capsules

1988 ◽  
Vol 22 (2) ◽  
pp. 130-133 ◽  
Author(s):  
Lyn Y. Nishimura ◽  
Edward P. Armstrong ◽  
Patricia M. Plezia ◽  
Robert P. Iacono
Keyword(s):  
Single Dose ◽  
Healthy Adult ◽  
Relative Bioavailability ◽  
Sodium Absorption ◽  
Crossover Fashion ◽  
Phenytoin Sodium ◽  
Enteral Feedings ◽  
Blood Specimens ◽  
Two Phases ◽  
Adult Volunteers

The influence of enteral feedings (with Ensure) on the absorption of phenytoin sodium from capsules was studied. Six healthy adult volunteers were given a single dose of phenytoin capsules 400 mg po on two occasions. Blood specimens were collected for 48 hours after each dose. In a randomized, crossover fashion, each subject completed the following two phases: (1) phenytoin without enteral feedings, and (2) concomitant enteral feedings before phenytoin and continued at 100 ml/h for ten hours. The areas under the concentration versus time curves from 0-48 hours (AUCo-48) were not significantly different between the two phases (p > 0.5). The percent relative bioavailability of phenytoin with enteral feedings was 101.7 percent. This study suggests that enteral feedings do not affect the serum concentrations of phenytoin after a single dose given in capsule form.

The Effect of Food on the Absorption of Pivampicillin and a Comparison with the Absorption of Ampicillin Potassium

1973 ◽  
Vol 1 (6) ◽  
pp. 530-533 ◽  
Author(s):  
C A Fernandez ◽  
J P Menezes ◽  
J Ximenes
Keyword(s):  
Single Dose ◽  
Healthy Adult ◽  
Serum Levels ◽  
Peak Serum ◽  
Substantial Decrease ◽  
Clinical Use ◽  
Fasting State ◽  
Lower Serum ◽  
Effect Of Food ◽  
Antibiotic Coverage

The effect of food on the absorption of pivampicillin hydrochloride and ampicillin potassium was compared in a single-dose, 3-way, cross-over study in fifteen healthy adult subjects. The antibiotics were given in their recommended doses in capsule form: 350 mg of pivampicillin and 500 mg of ampicillin. Ampicillin was administered in the fasting state while pivampicillin was administered both in the fasting state and during a standardized cooked breakfast. The presence of food caused a substantial decrease and delay in the absorption of pivampicillin. Pivampicillin administered during a meal, as recommended to minimize gastro-intestinal irritation, resulted in lower serum levels than those attained with ampicillin given without food. The average peak serum levels of pivampicillin taken during meals was 3.34 mcg/ml compared to 4.47 mcg/ml with ampicillin given in the fasting state. The total antibiotic coverage indicated by time-absorption curves was also considerably lower with pivampicillin than with ampicillin under conditions simulating those recommended during clinical use by the respective manufacturers.

Sign in / Sign up

Export Citation Format

Share Document