HEAL Pain DOSE Trial of Opioid Sparing Effect

Author(s):  
HPB ◽  
2018 ◽  
Vol 20 ◽  
pp. S214
Author(s):  
Å.A. Fretland ◽  
J. Hausken ◽  
B. Edwin ◽  
M.H. Andersen ◽  
V.J. Dagenborg ◽  
...  

1998 ◽  
Vol 87 (1) ◽  
pp. 103-106 ◽  
Author(s):  
Nergiz Kucuk ◽  
Mehmet Kizilkaya ◽  
Murat Tokdemir

Author(s):  
Sudar Codi R. ◽  
Sumina . ◽  
Uma N. ◽  
Manimekalai K.

Background: Adjuvant analgesics are added to pain management regimen to reduce opioid consumption and minimise their side effect. Newer ones like dexmedetomidine and pregabalin have not been thoroughly researched. Objectives of the study to study the opioid sparing effect of dexmedetomidine and pregabalin using tail flick and hot plate method in male wistar rats.Methods: Forty two rats were grouped into seven groups with six in each group. Analgesic activity was tested using tail flick, where in the reaction time to flick its tail on a heated surface was noted. In the hot plate method, the reaction time to withdraw or lick the paws when placed on heated surface was noted.Results: The reaction time to flick its tail was prolonged with dexmedetomidine and pregabalin when combined with opioids even in sub therapeutic doses.Conclusion: Adjuncts like dexmedetomidine and pregabalin can be very useful  in mutimodal pain management and also to reduce the opioid consumption.


2012 ◽  
Vol 56 (4) ◽  
pp. 164 ◽  
Author(s):  
A. Pesonen ◽  
R. Suojaranta-Ylinen ◽  
E. Hammarén ◽  
V. K. Kontinen ◽  
P. Raivio ◽  
...  

2017 ◽  
Vol 42 (9) ◽  
pp. 1752-1765 ◽  
Author(s):  
Suzanne Nielsen ◽  
Pamela Sabioni ◽  
Jose M Trigo ◽  
Mark A Ware ◽  
Brigid D Betz-Stablein ◽  
...  

2020 ◽  
Vol Publish Ahead of Print ◽  
Author(s):  
Xin-qi Cheng ◽  
Mao-yun Zhang ◽  
Qi Fang ◽  
De-wen Shi ◽  
Xiao-ci Huang ◽  
...  

2014 ◽  
Vol 28 (1) ◽  
pp. 23-27 ◽  
Author(s):  
Robab Maghsoudi ◽  
Meghdad Tabatabai ◽  
Mohammad Hadi Radfar ◽  
Gholamreza Movasagi ◽  
Masoud Etemadian ◽  
...  

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