Effects of Escitalopram on the Sleep EEG Power in Patients With Major Depressive Disorder

Objective: To clarify the effects of escitalopram on sleep EEG power in patients with Major depressive disorder (MDD).Method: Polysomnography (PSG) was detected overnight, and blood samples were collected at 4 h intervals over 24 h from 13 male healthy controls and 13 male MDD patients before and after treatment with escitalopram for 8 weeks. The outcome measures included plasma melatonin levels, sleep architecture, and the sleep EEG power ratio.Results: Compared with healthy controls, MDD patients presented abnormalities in the diurnal rhythm of melatonin secretion, including peak phase delayed 3 h and a decrease in plasma melatonin levels at night and an increase at daytime, accompanied by sleep disturbances, a decrease in low-frequency bands and an increase in high-frequency bands, and the dominant right-side brain activity. Several of these abnormalities (abnormalities in the diurnal rhythm of melatonin secretion, partial sleep architecture parameters) persisted for at least the 8-week testing period.Conclusions: Eight weeks of treatment with escitalopram significantly improved subjective sleep perception and depressive symptoms of patients with MDD, and partially improved objective sleep parameters, while the improvement of circadian rhythm of melatonin was limited.

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Morning and evening TSH response to TRH and sleep EEG disturbances in major depressive disorder

Progress in Neuro-Psychopharmacology and Biological Psychiatry ◽

10.1016/s0278-5846(00)00185-8 ◽

2001 ◽

Vol 25 (3) ◽

pp. 534-547 ◽

Cited By ~ 13

Author(s):

Luc Staner ◽

Fabrice Duval ◽

Francoise Calvi-Gries ◽

Marie-Claude Mokrani ◽

Paul Bailey ◽

...

Keyword(s):

Major Depressive Disorder ◽

Depressive Disorder ◽

Sleep Eeg ◽

Major Depressive

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Sleep EEG spectral power is correlated with subjective-objective discrepancy of sleep onset latency in major depressive disorder

Progress in Neuro-Psychopharmacology and Biological Psychiatry ◽

10.1016/j.pnpbp.2018.04.010 ◽

2018 ◽

Vol 85 ◽

pp. 122-127 ◽

Cited By ~ 5

Author(s):

Seung-Gul Kang ◽

Sara Mariani ◽

Stephanie A. Marvin ◽

Kwang-Pil Ko ◽

Susan Redline ◽

...

Keyword(s):

Major Depressive Disorder ◽

Depressive Disorder ◽

Spectral Power ◽

Sleep Onset ◽

Sleep Eeg ◽

Sleep Onset Latency ◽

Onset Latency ◽

Major Depressive ◽

Eeg Spectral Power

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A research project aimed at developing practical use of sleep EEG for diagnosis of major depressive disorder: multicenter exploratory prospective study

Sleep Medicine ◽

10.1016/j.sleep.2017.11.508 ◽

2017 ◽

Vol 40 ◽

pp. e173-e174

Author(s):

K. Kuriyama ◽

M. Suzuki ◽

H. Kadotani ◽

H. Yoshinaka ◽

M. Yamanaka ◽

...

Keyword(s):

Major Depressive Disorder ◽

Depressive Disorder ◽

Prospective Study ◽

Sleep Eeg ◽

Major Depressive ◽

Research Project

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Spatio-temporal dynamics of EEG features during sleep in major depressive disorder after treatment with escitalopram:A pilot study

10.21203/rs.2.16941/v1 ◽

2019 ◽

Author(s):

Li Wu ◽

Xue-Qin Wang ◽

Teng-Fei Dong ◽

Ling Lei ◽

Su-Xia Li ◽

...

Keyword(s):

Major Depressive Disorder ◽

Depressive Disorder ◽

Right Hemisphere ◽

Temporal Dynamics ◽

Sleep Eeg ◽

Sleep Stages ◽

Major Depressive ◽

Pharmacological Mechanism ◽

Spatio Temporal ◽

Eeg Features

Abstract Background: Previous studies have shown escitalopram is related to sleep quality. However, effects of escitalopram on dynamics of electroencephalogram (EEG) features especially during different sleep stages have not been reported. This study may help to reveal pharmacological mechanism underlying escitalopram treatment.Methods: The spatial and temporal responses of patients with major depressive disorder (MDD) to escitalopram treatment were analyzed in this study. Eleven MDD patients and eleven healthy control subjects who completed whole tests were included in the final statistics. Six-channel sleep EEG signals were acquired during sleep. Power spectrum and nonlinear dynamics were used to analyze the spatio-temporal dynamics features of the sleep EEG after escitalopram treatment. Results: For temporal dynamics: after treatment, there was a significant increase in the relative energy (RE) of band, accompanied by a significant decrease in the RE of band. Lempel-Ziv complexity and C0 complexity values were significantly lower. EEG changes at different sleep stages also showed the same regulation as the whole sleep process. For spatio dynamics: after treatment, the EEG response of the left and right hemisphere showed asymmetry. Further analysis of brain region-specific targets found that the frontal cortex showed a more intense EEG response with escitalopram treatment than central and occipital cortices.Conclusions: These findings may contribute to a comprehensive understanding of the pharmacological mechanism of escitalopram in the treatment of depression.

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