Pramipexole to Target "Anhedonic Depression"

Background: This study examined the efficacy Attention Bias Modification Training (ABMT) for the treatment of depression. Methods: In this randomized clinical trial, 145 adults (77% female, 62% white) with at least moderate depression severity (i.e., self-reported Quick Inventory of Depressive Symptomatology (QIDS-SR) ≥ 13) and a negative attention bias were randomized to active ABMT, sham ABMT, or assessments only. Training consisted of two in-clinic and three (brief) at-home ABMT sessions per week for four weeks (2,224 training trials total). The pre-registered primary outcome was change in QIDS-SR. Secondary outcomes were the 17-item Hamilton Depression Rating Scale (HRSD) and anhedonic depression and anxious arousal from the Mood and Anxiety Symptom Questionnaire (MASQ). Primary and secondary outcomes were administered at baseline and four weekly assessments during ABMT. Results: Intent-to-treat analyses indicated that, relative to assessment only, active ABMT significantly reduced QIDS-SR and HRSD scores by an additional 0.62 ± 0.23 (p = .008, d = -0.57) and 0.74 ± 0.31 (p = .021, d = -0.49) points per week. Similar results were observed for active vs sham ABMT: a greater symptom reduction of 0.44 ± 0.24 QIDS-SR (p = .067, d = -0.41) and 0.69 ± 0.32 HRSD (p = .033, d = -0.42) points per week. Sham ABMT did not significantly differ from the assessment-only condition. No significant differences were observed for the MASQ scales.Conclusion: Depressed individuals with at least modest negative attentional bias benefitted from active ABMT.

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Structure of Affect in Types of Anxiety and Depression

Journal of Individual Differences ◽

10.1027/1614-0001/a000279 ◽

2019 ◽

Vol 40 (2) ◽

pp. 82-91

Author(s):

Ewa Domaradzka ◽

Małgorzata Fajkowska

Keyword(s):

Anxiety And Depression ◽

Positive And Negative Affect ◽

Regression Analyses ◽

Structural Components ◽

Affective Functioning ◽

Similarities And Differences ◽

Anhedonic Depression ◽

Structure And Functions ◽

Anxiety Arousal ◽

Expanded Form

Abstract. Although anxiety and depression are treated as separate conditions, the literature concerning their affective functioning is inconclusive. To address this issue, we analyzed types of anxiety (arousal and apprehension) and depression (valence and anhedonic). We hypothesized that the similarities and differences in the structure of affect would be related to the specific structural components and functions (reactive or regulative) of the types. We assessed the valence (negative and positive affect) and content (specific emotions) of affect by the Positive and Negative Affect Schedule – Expanded Form (PANAS-X) in 1,632 participants from a general population. Regression analyses showed that the anxiety and depression types (measured by Anxiety and Depression Questionnaire) can be differentiated by the content of affect, but not its valence: Fear was characteristic for anxiety, especially the arousal anxiety. Valence depression was primarily related to hostility, while anhedonic depression was predicted by sadness, guilt, and lowered joviality. Moreover, as expected, regulative emotions (e.g., joviality) were stronger predictors of the regulative apprehension anxiety and anhedonic depression, while the more reactive fear was more strongly related to the reactive arousal anxiety than to regulative apprehension anxiety. These results confirm that the structure of affect is related to the structure and functions of anxiety and depression types.

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Efficacy of attention bias modification training for depressed adults: a randomized clinical trial

Psychological Medicine ◽

10.1017/s0033291721000702 ◽

2021 ◽

pp. 1-9

Author(s):

Kean J. Hsu ◽

Jason Shumake ◽

Kayla Caffey ◽

Semeon Risom ◽

Jocelyn Labrada ◽

...

Keyword(s):

Clinical Trial ◽

Randomized Clinical Trial ◽

Rating Scale ◽

Depressive Symptomatology ◽

Attention Bias ◽

Attention Bias Modification ◽

Secondary Outcomes ◽

Intent To Treat ◽

Anhedonic Depression ◽

Bias Modification

Abstract Background This study examined the efficacy of attention bias modification training (ABMT) for the treatment of depression. Methods In this randomized clinical trial, 145 adults (77% female, 62% white) with at least moderate depression severity [i.e. self-reported Quick Inventory of Depressive Symptomatology (QIDS-SR) ⩾13] and a negative attention bias were randomized to active ABMT, sham ABMT, or assessments only. The training consisted of two in-clinic and three (brief) at-home ABMT sessions per week for 4 weeks (2224 training trials total). The pre-registered primary outcome was change in QIDS-SR. Secondary outcomes were the 17-item Hamilton Depression Rating Scale (HRSD) and anhedonic depression and anxious arousal from the Mood and Anxiety Symptom Questionnaire (MASQ). Primary and secondary outcomes were administered at baseline and four weekly assessments during ABMT. Results Intent-to-treat analyses indicated that, relative to assessment-only, active ABMT significantly reduced QIDS-SR and HRSD scores by an additional 0.62 ± 0.23 (p = 0.008, d = −0.57) and 0.74 ± 0.31 (p = 0.021, d = −0.49) points per week. Similar results were observed for active v. sham ABMT: a greater symptom reduction of 0.44 ± 0.24 QIDS-SR (p = 0.067, d = −0.41) and 0.69 ± 0.32 HRSD (p = 0.033, d = −0.42) points per week. Sham ABMT did not significantly differ from the assessment-only condition. No significant differences were observed for the MASQ scales. Conclusion Depressed individuals with at least modest negative attentional bias benefitted from active ABMT.

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