Rotational Thromboelastometry (ROTEM) TRUE-NATEM Reference Value Validation in Liver Transplantation

2020 ◽  
Author(s):  
Keyword(s):  
Liver Transplantation ◽  
Reference Value ◽  
Rotational Thromboelastometry

scholarly journals Effect of magnesium on rotational thromboelastometry (ROTEM) and total blood products requirement in patients undergoing liver transplantation

2012 ◽  
Vol 28 (2) ◽  
pp. 101-105 ◽  
Author(s):  
Mohamed A. Hammouda ◽  
Hisham S. Khedr ◽  
Mohamed A. Alrabiey ◽  
Ahmed M. AbdEl-Hamid ◽  
Ahmed M. AbdEl-Azim
Keyword(s):  
Liver Transplantation ◽  
Blood Products ◽  
Total Blood ◽  
Rotational Thromboelastometry

Analysis of the hemostatic therapy in liver transplantation guided by rotational thromboelastometry or conventional laboratory tests

2020 ◽  
Vol 32 (11) ◽  
pp. 1452-1457 ◽  
Author(s):  
Jose C.R. Nascimento ◽  
Edson B.L. Neto ◽  
Eliana L. da Silva ◽  
Rogean R. Nunes ◽  
David S. Marinho ◽  
...  
Keyword(s):  
Liver Transplantation ◽  
Laboratory Tests ◽  
Rotational Thromboelastometry ◽  
Hemostatic Therapy

scholarly journals Using Rotational Thromboelastometry to Identify Early Allograft Dysfunction after Living Donor Liver Transplantation

2021 ◽  
Vol 10 (15) ◽  
pp. 3401
Author(s):  
Chen-Fang Lee ◽  
Hao-Chien Hung ◽  
Wei-Chen Lee
Keyword(s):  
Liver Transplantation ◽  
Negative Predictive Value ◽  
Predictive Value ◽  
Living Donor ◽  
Living Donor Liver Transplantation ◽  
Donor Liver ◽  
Rotational Thromboelastometry ◽  
Donor Liver Transplantation ◽  
Early Allograft Dysfunction ◽  
Maximum Clot Firmness

Background: Diagnostic tests for early allograft dysfunction (EAD) after living donor liver transplantation (LDLT) vary widely. We aimed to evaluate the predictive value of rotational thromboelastometry (ROTEM)-derived parameters in EAD. Materials and Methods: A total of 121 patients were reviewed. The definition of EAD proposed by Olthoff et al. included the presence of any of the following at postoperative day 7: bilirubin level ≥ 10 mg/dL, INR ≥ 1.6, or serum AST or ALT levels > 2000 IU/L. All patients underwent ROTEM assay, which consisted of an extrinsically activated thromboelastometric test (EXTEM) before and 24 h after LDLT. Results: The 1-year/2-year OS were 68.%8/64.5% and 94.4%/90.8% for the EAD and non-EAD groups, respectively (p = 0.001). Two independent risks were identified for EAD, the postoperative clotting time (CT, p = 0.026) and time to maximum clot firmness (maximum clot firmness (MCF)-t, p = 0.009) on the EXTEM. CT yielded a specificity of 82.0% and negative predictive value of 83.0%, and MCF-t displayed a specificity of 76.4% and negative predictive value of 81.9% in diagnosing EAD. The use of the 24 h post-LDLT ROTEM increased the effectiveness of predicting overall survival (OS) compared to using the Olthoff’s EAD criteria alone (p < 0.001). Conclusion: We conclude that CT and MCF on EXTEM were independent predictors of EAD. The 24 h post-LDLT ROTEM can be used with conventional laboratory tests to diagnose EAD. It increases the effectiveness of predicting OS.

The Utility of Thromboelastography to Guide Blood Product Transfusion

2019 ◽  
Vol 152 (4) ◽  
pp. 407-422 ◽  
Author(s):  
Amy E Schmidt ◽  
Anna Karolina Israel ◽  
Majed A Refaai
Keyword(s):  
Liver Transplantation ◽  
Patient Management ◽  
Blood Product ◽  
Blood Product Transfusion ◽  
Blood Components ◽  
Blood Products ◽  
Case Scenario ◽  
Rotational Thromboelastometry ◽  
Coagulation Assays ◽  
Testing Technology

AbstractObjectivesTo provide an overview of the clot viscoelastic testing technology and to describe its utility in guiding blood product transfusions.MethodsA case scenario will be discussed as well as interpretation of thromboelastography (TEG) tracings. In addition, literature examining the utility of viscoelastic testing in guiding patient management and blood product transfusions will be reviewed.ResultsTEG/rotational thromboelastometry (ROTEM) is useful in evaluating clot kinetics in trauma and acutely bleeding patients. TEG/ROTEM parameters are reflective of values measured using standard coagulation assays; however, TEG/ROTEM parameters are more rapidly available and more costly. TEG and ROTEM are used in three main settings: cardiac surgery, liver transplantation, and trauma to assess global hemostasis and administration of blood products.ConclusionsTEG/ROTEM can be helpful in guiding resuscitation and blood product transfusion. Several studies have demonstrated a reduction in transfusion of blood components with TEG/ROTEM; however, other studies have suggested that TEG/ROTEM is not clinically effective in guiding transfusion.

scholarly journals Comparison of standard coagulation tests and rotational thromboelastometry for hemostatic system monitoring during orthotopic liver transplantation: Results from a pilot study

2015 ◽  
Vol 68 (9-10) ◽  
pp. 301-307 ◽  
Author(s):  
Sladjana Novakovic-Anucin ◽  
Dusica Kosanovic ◽  
Sanja Gnip ◽  
Visnja Canak ◽  
Velibor Cabarkapa ◽  
...  
Keyword(s):  
Liver Transplantation ◽  
Platelet Count ◽  
Fibrinogen Level ◽  
Activated Partial Thromboplastin Time ◽  
Coagulation Time ◽  
Rotational Thromboelastometry ◽  
Hemostatic System ◽  
Coagulation Tests ◽  
Clot Formation Time ◽  
Maximum Clot Firmness

Introduction. During liver transplantation, continuous laboratory monitoring of complex changes of the hemostatic system is necessary. The aim of this study was to compare two methods of monitoring: standard coagulation tests and rotational thromboelastometry. Material and Methods. The study included 17 patients who had undergone orthotopic liver transplantation in the Clinical Centre of Vojvodina, Serbia in the period from June 2008 to October 2012. The coagulation parameters (platelet count, activated partial thromboplastin time, prothrombin time and fibrinogen level) were compared with the thromboelastometric parameters (coagulation time, clot formation time and maximal clot firmness). Results. The results showed a statistically significant correlation between the platelet count and maximum clot firmness of the intrinsically (r=0.51, p<0.001) and extrinsically activated thromboelastometric assays (r=0.64, p<0.001). The fibrinogen level and maximum clot firmness of the fibrinogen thromboelastometric test correlated significantly as well (r=0.44, p=0.002). No significant correlations were found among the activated partial thromboplastin time, prothrombin time, coagulation time and clot formation time. Conclusion. For an adequate perioperative monitoring of the dynamic intraoperative hemostatic changes and the optimal use of blood derivatives during liver transplantation, the combined application of standard coagulation tests and rotational thromboelastometry should be considered whenever possible. Science and Technological Development, Republic of Serbia

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