scholarly journals Terminal spreading depolarizations causing electrocortical silencing prior to clinical brain death: case report

2019 ◽  
Vol 131 (6) ◽  
pp. 1773-1779 ◽  
Author(s):  
Andrew P. Carlson ◽  
C. William Shuttleworth ◽  
Sebastian Major ◽  
Coline L. Lemale ◽  
Jens P. Dreier ◽  
...  

The authors report on a 57-year-old woman in whom progression to brain death occurred on day 9 after aneurysmal subarachnoid hemorrhage without evidence of significant brain edema or vasospasm. Neuromonitoring demonstrated that brain death was preceded by a series of cortical spreading depolarizations that occurred in association with progressive hypoxic episodes. The depolarizations induced final electrical silence in the cortex and ended with a terminal depolarization that persisted > 7 hours. To the authors’ knowledge, this is the first report of terminal spreading depolarization in the human brain prior to clinical brain death and major cardiopulmonary failure.

Nosotchu ◽  
1991 ◽  
Vol 13 (5) ◽  
pp. 400-404
Author(s):  
Masaaki Yamamoto ◽  
Tsuyomi Mizoguchi ◽  
Kouichi Shinohara ◽  
Akihiko Sakaue ◽  
Masamichi Tomonaga

Neurosurgery ◽  
1985 ◽  
Vol 17 (3) ◽  
pp. 474-479 ◽  
Author(s):  
Jacob Rosenstein ◽  
Hunt H. Batjer ◽  
Duke S. Samson

Abstract Cerebral arterial vasospasm after aneurysmal subarachnoid hemorrhage remains one of the major causes of morbidity and mortality in patients surviving the initial hemorrhage. Once established, no known method has been shown to reverse this process in humans. Although intravascular volume expansion and induced arterial hypertension have been shown to be effective in the reversal of neurological deficits secondary to vasospasm, a large proportion of patients remain refractory to these methods. We report one such case successfully managed by the estalishment of an extracranial-intracranial anastomosis in an attempt to augment collateral flow.


2014 ◽  
Vol 54 (3) ◽  
pp. 231-235 ◽  
Author(s):  
Hayato TAKEUCHI ◽  
Kazuhide IWAMOTO ◽  
Mao MUKAI ◽  
Tomoaki FUJITA ◽  
Hitoshi TSUJINO ◽  
...  

2011 ◽  
Vol 32 (2) ◽  
pp. 201-202 ◽  
Author(s):  
Anthony J Strong ◽  
R Loch Macdonald

There are longstanding inconsistencies in the evidence thought to link vasospasm in the major branches of the Circle of Willis with delayed cerebral ischemia and poor outcome from aneurysmal subarachnoid hemorrhage (aSAH). The demonstrations, first in the laboratory, and more recently in patients with aSAH, of cortical spreading ischemia based on an abnormal response of the cerebral microcirculation to spreading depolarization offer an additional possible mechanism for delayed ischemia. That such events can occur in the substantial absence of proximal vasospasm is compatible with this concept, but the preliminary evidence needs support from more extensive studies.


2007 ◽  
Vol 47 (6) ◽  
pp. 258-260 ◽  
Author(s):  
Akihiro KUROSU ◽  
Katsumi SUZUKAWA ◽  
Masashi AMO ◽  
Naoaki HORINAKA ◽  
Hajime ARAI

1997 ◽  
Vol 37 (8) ◽  
pp. 612-615 ◽  
Author(s):  
Tsuneaki OGIICHI ◽  
Shunro ENDO ◽  
Keiichiro ONIZUKA ◽  
Michiyasu TAKABA ◽  
Akira TAKAKU ◽  
...  

2010 ◽  
Vol 25 (1) ◽  
pp. 53-64 ◽  
Author(s):  
Ari R. Joffe ◽  
Laurance Lequier ◽  
Dominic Cave

2020 ◽  
Vol 87 (3) ◽  
pp. 162-165
Author(s):  
Kohei Hironaka ◽  
Masanori Suzuki ◽  
Kojiro Tateyama ◽  
Tomohiro Ozeki ◽  
Koji Adachi ◽  
...  

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