Transforming Research and Clinical Knowledge in Spinal Cord Injury (TRACK-SCI): an overview of initial enrollment and demographics

OBJECTIVETraumatic spinal cord injury (SCI) is a dreaded condition that can lead to paralysis and severe disability. With few treatment options available for patients who have suffered from SCI, it is important to develop prospective databases to standardize data collection in order to develop new therapeutic approaches and guidelines. Here, the authors present an overview of their multicenter, prospective, observational patient registry, Transforming Research and Clinical Knowledge in SCI (TRACK-SCI).METHODSData were collected using the National Institute of Neurological Disorders and Stroke (NINDS) common data elements (CDEs). Highly granular clinical information, in addition to standardized imaging, biospecimen, and follow-up data, were included in the registry. Surgical approaches were determined by the surgeon treating each patient; however, they were carefully documented and compared within and across study sites. Follow-up visits were scheduled for 6 and 12 months after injury.RESULTSOne hundred sixty patients were enrolled in the TRACK-SCI study. In this overview, basic clinical, imaging, neurological severity, and follow-up data on these patients are presented. Overall, 78.8% of the patients were determined to be surgical candidates and underwent spinal decompression and/or stabilization. Follow-up rates to date at 6 and 12 months are 45% and 36.3%, respectively. Overall resources required for clinical research coordination are also discussed.CONCLUSIONSThe authors established the feasibility of SCI CDE implementation in a multicenter, prospective observational study. Through the application of standardized SCI CDEs and expansion of future multicenter collaborations, they hope to advance SCI research and improve treatment.

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Traumatic Spinal Cord Injury: Long-Term Motor, Sensory, and Urinary Outcomes

Asian Spine Journal ◽

10.4184/asj.2017.11.3.412 ◽

2017 ◽

Vol 11 (3) ◽

pp. 412-418 ◽

Cited By ~ 7

Author(s):

Rouzbeh Motiei-Langroudi ◽

Homa Sadeghian

Keyword(s):

Spinal Cord ◽

Spinal Cord Injury ◽

Spinal Injury ◽

Treatment Protocol ◽

Spinal Column ◽

Surgical Approaches ◽

Trauma Mechanism ◽

Cord Injury

<sec><title>Study Design</title>Retrospective study.</sec><sec><title>Purpose</title>To evaluate how motor, sensory, and urinary outcomes of spinal cord injury (SCI) patients were influenced in the long term.</sec><sec><title>Overview of Literature</title>SCI is a potentially disabling and devastating neurological outcome that can occur because of spinal column fractures. Most studies have not evaluated or have failed to show the influence of different surgical approaches and other parameters on neurological recovery.</sec><sec><title>Methods</title>A thorough history regarding sensory, motor, and urinary complaints was taken from 103 patients with SCI due to vertebral fracture; patients were followed by a thorough neurological examination. Subsequently, all medical records of patients, including neurological state after trauma, trauma mechanism, treatment protocol, surgical protocol, and imaging findings, were evaluated.</sec><sec><title>Results</title>Of the 103 patients, 73.8% were survivors of a major earthquake and 26.2% were victims of vehicle accidents; 92.2% patients were surgically treated, while 7.8% underwent conservative management. The mean follow-up duration was 10.3 years. In follow-up visits, 67.0%, 12.6%, 13.6%, and 6.8% patients showed no, partial, substantial, and complete motor improvement, respectively; 68.0%, 26.2%, and 5.8% showed no, mild, and substantial sensory improvement, respectively; and 73.8%, 17.5%, and 8.7% showed no, substantial, and complete urinary improvement, respectively. Logistic regression analysis showed that sex, age at injury time, follow-up duration, trauma mechanism, and stem cell therapy had no effect on motor, sensory, and urinary improvement. Higher initial scores on the American Spinal Injury Association (ASIA) classification, lumbar fracture level, and performance of laminectomy improved motor outcome; higher initial ASIA scores improved urinary and sensory outcomes.</sec><sec><title>Conclusions</title>The initial ASIA score is the most important factor for prognosticating motor, sensory, and urinary improvement in SCI patients. Lumbar (L3–L5) and thoracic (T1–T10) fractures have the best and worst prognosis, respectively, in terms of motor recovery. Laminectomy during surgery improves motor function.</sec>

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1232: Long-Term Urodynamic Follow-Up in Patients with Spinal Cord Injury: Is it Really Necessary

The Journal of Urology ◽

10.1016/s0022-5347(18)35377-1 ◽

2005 ◽

Vol 173 (4S) ◽

pp. 334-334

Author(s):

Juergen Pannek ◽

Michael Nosseir

Keyword(s):

Spinal Cord ◽

Spinal Cord Injury ◽

Cord Injury

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Long-Term Follow-Up After Spinal Cord Injury in Canada

PsycEXTRA Dataset ◽

10.1037/e513252007-001 ◽

2006 ◽

Author(s):

Mark I. Tonack ◽

Sander L. Hitzig ◽

B. Catharine Craven ◽

Kent A. Campbell ◽

Kathryn A. Boschen ◽

...

Keyword(s):

Spinal Cord ◽

Spinal Cord Injury ◽

Cord Injury ◽

Long Term Follow Up

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OPEN HAEMORRHOIDS SURGERY IN SPINAL CORD INJURY PATIENTS

International Journal of Medical and Biomedical Studies ◽

10.32553/ijmbs.v4i11.1532 ◽

2020 ◽

Vol 4 (11) ◽

Author(s):

Khaled Hassan

Keyword(s):

Spinal Cord ◽

Spinal Cord Injury ◽

Anal Fissure ◽

Open Surgery ◽

Anal Fissures ◽

Cord Injury ◽

Long Term Follow Up ◽

Grade Iii

This Pilot retrospective research conducted on the results of open surgery in patients with Grade III and IV haemorrhoids With SCI. No major complications had arisen at 6 weeks post-operative and all wounds had healed, but 1 patient Anal fissure recurrence. 75% of patients reported a substantial increase in anorectal anorexia during long-term follow-up. With symptoms. Five patients reported recurrences: three haemorrhoids (18 percent) and two anal fissures (25 percent). Keywords: Haemorrhoids, Pilot retrospective research, Anorectal Anorexia.

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“Proximalization is Advancement”—Zone 3 Frozen Elephant Trunk vs Zone 2 Frozen Elephant Trunk: A Literature Review

Vascular and Endovascular Surgery ◽

10.1177/15385744211002493 ◽

2021 ◽

pp. 153857442110024

Author(s):

Rozina Yasmin Choudhury ◽

Kamran Basharat ◽

Syeda Anum Zahra ◽

Tien Tran ◽

Lara Rimmer ◽

...

Keyword(s):

Spinal Cord ◽

Spinal Cord Injury ◽

Surgical Treatment ◽

Literature Review ◽

Treatment Options ◽

Frozen Elephant Trunk ◽

Elephant Trunk ◽

Descending Aorta ◽

Cord Injury ◽

Aortic Pathologies

Over the decades, the Frozen Elephant Trunk (FET) technique has gained immense popularity allowing simplified treatment of complex aortic pathologies. FET is frequently used to treat aortic conditions involving the distal aortic arch and the proximal descending aorta in a single stage. Surgical preference has recently changed from FET procedures being performed at Zone 3 to Zone 2. There are several advantages of Zone 2 FET over Zone 3 FET including reduction in spinal cord injury, visceral ischemia, neurological and cardiovascular sequelae. In addition, Zone 2 FET is a technically less complicated procedure. Literature on the comparison between Zone 3 and Zone 2 FET is scarce and primarily observational and anecdotal. Therefore, further research is warranted in this paradigm to substantiate current surgical treatment options for complex aortic pathologies. In this review, we explore literature surrounding FET and the reasons for the shift in surgical preference from Zone 3 to Zone 2.

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