Comparison of intervertebral disc disease treatment by chymopapain injection and open surgery

1975 ◽  
Vol 42 (4) ◽  
pp. 397-400 ◽  
Author(s):  
Clark Watts ◽  
Gary Hutchison ◽  
Jack Stern ◽  
Kemp Clark
Keyword(s):  
Intervertebral Disc ◽  
Open Surgery ◽  
Intervertebral Disc Disease ◽  
Disc Disease ◽  
Disease Treatment ◽  
Lumbar Intervertebral Disc ◽  
Content Type ◽  
Fine Print

✓ Chymopapain chemonucleolysis was performed on 100 patients with primary lumbar intervertebral disc disease. The results were compared with those of 174 patients who underwent laminotomy, foraminotomy, and discectomy. Primary lumbar intervertebral disc disease was arbitrarily divided into degenerative, complex, previous surgical, and simple disc syndromes. No difference was seen between chemonucleolysis and surgery in the first three divisions; between 55% and 60% of patients responded successfully to treatment. In the simple disc division 89% of the surgical and 60% of the chemonucleolysis patients had successful results.

Treatment of protruded lumbar intervertebral discs with chymopapain (Discase)

1973 ◽  
Vol 39 (2) ◽  
pp. 203-208 ◽  
Author(s):  
Dwight Parkinson ◽  
Christopher Shields
Keyword(s):  
Intervertebral Disc ◽  
Drug Administration ◽  
Food And Drug Administration ◽  
Intervertebral Discs ◽  
Intervertebral Disc Disease ◽  
Disc Disease ◽  
Chemical Action ◽  
Content Type ◽  
Fine Print

✓ Thirty-three intervertebral disc patients who otherwise would have been subjected to surgery were treated by injection with chymopapain. The pharmacology, toxicology, physiology, immunology, and chemical action of this enzyme, which specifically reacts with chondromucoproteins, are discussed. Results indicate that this method, although still experimental and unapproved by the U. S. Food and Drug Administration, may become a useful addition to the surgeon's armamentarium in the treatment of intervertebral disc disease.

Chymopapain treatment of intervertebral disc disease

1975 ◽  
Vol 42 (4) ◽  
pp. 374-383 ◽  
Author(s):  
Clark Watts ◽  
Robert Knighton ◽  
George Roulhac
Keyword(s):  
Intervertebral Disc ◽  
Proteolytic Enzyme ◽  
Intervertebral Disc Disease ◽  
Disc Disease ◽  
Disc Space ◽  
Content Type ◽  
Disc Material ◽  
Capillary Endothelial Cells ◽  
Fine Print ◽  
Rapid Conversion

✓ In the first of a two-part study, the authors review the known biochemical, pharmacological, toxicological, and experimental data concerning chymopapain and the intervertebral disc. They describe the action of this proteolytic enzyme, which apparently disrupts the protein mucopolysaccharide component of disc material, most marked in the nucleus pulposus. A rapid conversion to collagen causes a loss of disc space height; toxicity appears to result from alteration of bonding between capillary endothelial cells that in turn produces hemorrhage. Part 2 reviews significant reported results and complications of clinical chemonucleolysis.

Late results of treatment of intervertebral disc disease with chymopapain

1983 ◽  
Vol 59 (6) ◽  
pp. 990-993 ◽  
Author(s):  
Dwight Parkinson
Keyword(s):  
Intervertebral Disc ◽  
First Generation ◽  
Clinical Pathology ◽  
Late Results ◽  
Intervertebral Disc Disease ◽  
Disc Disease ◽  
Content Type ◽  
Results Of Treatment ◽  
Fine Print

✓ The authors report a 12-year follow-up review of 33 patients treated with chymopapain (Discase) injection for intervertebral disc disease. This carefully controlled series of patients was treated under local anesthesia in the prone position. Only the single offending disc that correlated with the myelographic and clinical pathology (without the use of discography) was injected with Discase. Anaphylaxis is treated instantly at the first sign of disturbance, and no patients suffered shock. The percentage of patients who were completely cured or improved continues at about 70%. Aside from sensitivity, complications attributable to proper use of the enzyme remain at zero. Follow-up review of those patients over 10 years would indicate that there is no risk of delayed organ toxicity, no risk of carcinogenesis, and no apparent risk of first-generation teratogenesis.

Inadequacies and hazards of chymopapain injections as treatment for intervertebral disc disease

1975 ◽  
Vol 42 (4) ◽  
pp. 389-396 ◽  
Author(s):  
Bernard J. Sussman
Keyword(s):  
Intervertebral Disc ◽  
Nucleus Pulposus ◽  
Neural Tissue ◽  
Intervertebral Disc Disease ◽  
Disc Disease ◽  
Content Type ◽  
Fine Print

✓ The author reviews laboratory and clinical reports that lead him to believe that chymopapain does not specifically dissolve the nucleus pulposus and is toxic for vascular and neural tissue.

scholarly journals Retraction Notice: Lack of Relationship Between Occupational Workload and Microscopic Alterations in Lumbar Intervertebral Disc Disease

2017 ◽  
Vol 11 (1) ◽  
pp. 389-389
Author(s):  
Gerald Huschak ◽  
Hans-Jürgen Holzhausen ◽  
Andre Beier ◽  
Hans Jörg Meisel ◽  
Thomas Hoell
Keyword(s):  
Intervertebral Disc ◽  
Intervertebral Disc Disease ◽  
Disc Disease ◽  
Lumbar Intervertebral Disc ◽  
Retraction Notice ◽  
Occupational Workload

Spondylolisthesis following lumbar disc surgery in a child

1971 ◽  
Vol 34 (4) ◽  
pp. 563-568 ◽  
Author(s):  
Arthur Kobrine ◽  
Paul C. Bucy
Keyword(s):  
Intervertebral Disc ◽  
Case Reports ◽  
Lumbar Disc ◽  
Lumbar Disc Surgery ◽  
Lumbar Intervertebral Disc ◽  
Related Case ◽  
Content Type ◽  
Disc Surgery ◽  
Roentgenographic Examination ◽  
Fine Print

✓ The case of a 13-year-old boy with a gelatinous, herniated lumbar intervertebral disc is reported. Roentgenographic examination 8 years following laminectomy demonstrated spondylolysis and spondylolisthesis of L-5 on S-1. Related case reports and theories are tabulated and discussed.

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