A physiological sealant for cerebrospinal fluid leaks
1977 ◽
Vol 46
(2)
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pp. 215-219
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Keyword(s):
✓ A combination of concentrated platelets, thrombin, and fibrinogen was used to adhere a pericranial graft to surgically produced cerebrospinal fluid (CSF) fistulas in dogs. This sealant successfully stopped leakage of CSF in all fistulas produced in both acute and chronic preparations. All control animals leaked CSF acutely. In chronic control animals the CSF leaks sealed spontaneously but the grafts were not well incorporated. Histological examination of the grafts and underlying brain showed no injury to the brain or meningeal vessel from exposure to the platelet glue. Good fibrous union of the grafts to the dura was confirmed.
1979 ◽
Vol 51
(1)
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pp. 70-77
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Keyword(s):
1972 ◽
Vol 37
(3)
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pp. 364-367
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1980 ◽
Vol 52
(5)
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pp. 661-666
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1983 ◽
Vol 59
(4)
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pp. 718-722
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Keyword(s):
1982 ◽
Vol 56
(3)
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pp. 344-349
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2002 ◽
Vol 96
(3)
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pp. 483-489
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Keyword(s):
1996 ◽
Vol 84
(4)
◽
pp. 598-605
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