Outcomes of surgery in 1019 brachial plexus lesions treated at Louisiana State University Health Sciences Center

2003 ◽  
Vol 98 (5) ◽  
pp. 1005-1016 ◽  
Author(s):  
Daniel H. Kim ◽  
Yong-Jun Cho ◽  
Robert L. Tiel ◽  
David G. Kline
Keyword(s):  
Brachial Plexus ◽  
Gunshot Wounds ◽  
Neurological Status ◽  
Health Sciences ◽  
State University ◽  
Content Type ◽  
Lower Trunk ◽  
Louisiana State University ◽  
Fine Print

Object. Outcomes of 1019 brachial plexus lesions in patients who underwent surgery at Louisiana State University Health Sciences Center during a 30-year period are reviewed in this paper to provide management guidelines. Methods. Causes of brachial plexus lesions included 509 stretches/contusions (50%), 161 plexus tumors (16%), 160 thoracic outlet syndromes (TOSs, 16%), 118 gunshot wounds (12%), and 71 lacerations (7%). Many features of clinical presentation, including prior treatment, patient's neurological status, results of electrophysiological studies, intraoperative findings, and postoperative level of function, were studied. The minimum follow-up period was 18 months and the mean follow-up period was 42 months. Repairs were best for injuries located at the C-5, C-6, and C-7 levels, the upper and middle trunk, the lateral cord to the musculocutaneous nerve, and the median and posterior cords to the axillary and radial nerves. Conversely, results were poor for injuries at the C-8 and T-1 levels, and for lower trunk and medial cord lesions, with the exception of injuries of the medial cord to the median nerve. Outcomes were most favorable when patients were carefully evaluated and selected for surgery, although variables such as lesion type, location, and severity, as well as time since injury also affected outcome. This was true also of TOSs and tumors arising from the plexus, especially if they had not been surgically treated previously. Conclusions. Surgical exploration and repair of brachial plexus lesions is technically feasible and favorable outcomes can be achieved if patients are thoroughly evaluated and appropriately selected.

A series of 397 peripheral neural sheath tumors: 30-year experience at Louisiana State University Health Sciences Center

2005 ◽  
Vol 102 (2) ◽  
pp. 246-255 ◽  
Author(s):  
Daniel H. Kim ◽  
Judith A. Murovic ◽  
Robert L. Tiel ◽  
Gregory Moes ◽  
David G. Kline
Keyword(s):  
Brachial Plexus ◽  
Surgical Techniques ◽  
Neurofibromatosis Type ◽  
Health Sciences ◽  
High Morbidity ◽  
State University ◽  
Content Type ◽  
Louisiana State University ◽  
Neural Sheath ◽  
Fine Print

Object. This is a retrospective review of 397 benign and malignant peripheral neural sheath tumors (PNSTs) that were surgically treated between 1969 and 1999 at the Louisiana State University Health Sciences Center (LSUHSC). The surgical techniques and adjunctive treatments are presented, the tumors are classified with respect to type and prevalence at each neuroanatomical location, and the management of malignant PNSTs is reviewed. Methods. There were 361 benign PNSTs (91%). One hundred forty-one benign lesions were brachial plexus tumors: 54 schwannomas (38%) and 87 neurofibromas (62%), of which 55 (63%) were solitary neurofibromas and 32 (37%) were neurofibromatosis Type 1 (NF1)—associated neurofibromas. Among the brachial plexus lesions supraclavicular tumors predominated with 37 (69%) of 54 schwannomas; 34 (62%) of 55 solitary neurofibromas; and 19 (59%) of 32 NF1-associated neurofibromas. One hundred ten upper-extremity benign PNSTs consisted of 32 schwannomas (29%) and 78 neurofibromas (71%), of which 45 (58%) were sporadic neurofibromas and 33 (42%) were NF1-associated neurofibromas. Twenty-five benign PNSTs were removed from the pelvic plexus. Lower-extremity PNSTs included 32 schwannomas (38%) and 53 neurofibromas (62%), of which 31 were solitary neurofibromas and 22 were NF1-associated neurofibromas. There were 36 malignant PNSTs: 28 neurogenic sarcomas and eight other sarcomas (fibro-, spindle cell, synovial, and perineurial sarcomas). Conclusions. The majority of tumors were benign PNSTs from the brachial plexus region. Most of the benign PNSTs in all locations were neurofibromas, with sporadic neurofibromas predominating. Similar numbers of schwannomas were found in the upper and lower extremities, whereas neurofibromas were more prevalent in the upper extremities. Despite aggressive limb-ablation or limb-sparing surgery plus adjunctive therapy, malignant PNSTs continue to be associated with high morbidity and mortality rates.

A series of 146 peripheral non—neural sheath nerve tumors: 30-year experience at Louisiana State University Health Sciences Center

2005 ◽  
Vol 102 (2) ◽  
pp. 256-266 ◽  
Author(s):  
Daniel H. Kim ◽  
Judith A. Murovic ◽  
Robert L. Tiel ◽  
Gregory Moes ◽  
David G. Kline
Keyword(s):  
Brachial Plexus ◽  
Surgical Techniques ◽  
Health Sciences ◽  
Benign Tumors ◽  
State University ◽  
Pelvic Plexus ◽  
Content Type ◽  
Louisiana State University ◽  
Neural Sheath ◽  
Fine Print

Object. This is a retrospective review of 146 surgically treated benign and malignant peripheral non—neural sheath tumors (PNNSTs). Tumor classifications with patient numbers, locations of benign PNNSTs, and surgical techniques and adjunctive treatments are presented. The results of a literature review regarding tumor frequencies are presented. Methods. One hundred forty-six patients with 111 benign and 35 malignant PNNSTs were treated between 1969 and 1999 at the Louisiana State University Health Sciences Center (LSUHSC). The benign tumors included 33 ganglion cysts, 16 cases of localized hypertrophic neuropathy, 12 lipomas, 12 tumors of vascular origin, and 11 desmoid tumors. There were four each of lipofibrohamartomas, myositis ossificans, osteochondromas, and ganglioneuromas; two each of meningiomas, cystic hygromas, myoblastoma or granular cell tumors, triton tumors, and lymphangiomas; and one epidermoid cyst. The locations of benign PNNSTs were the following: 33 in the brachial plexus region, 39 in an upper extremity, one in the pelvic plexus, and 38 in a lower extremity. The malignant PNNSTs included 35 surgically treated carcinomas, 15 of which originated in the breast and nine in the lung. There were two melanomas metastatic to nerve and one tumor each that had metastasized from the bladder, rectum, skin, head and neck, and thyroid, and from a primary Ewing sarcoma. There was a single lymphoma that had metastasized to the radial nerve and one chordoma and one osteosarcoma, each of which had metastasized to the brachial plexus. Conclusions. There were more benign PNNSTs than malignant ones. Benign tumors were relatively equally distributed in the brachial plexus region and upper and lower extremities, with the exception of the pelvic plexus, which had only one tumor.

Outcomes in a consecutive series of 111 surgically treated plexal tumors: a review of the experience at the Louisiana State University Health Sciences Center

2001 ◽  
Vol 95 (1) ◽  
pp. 51-60 ◽  
Author(s):  
Aruna Ganju ◽  
Norbert Roosen ◽  
David G. Kline ◽  
Robert L. Tiel
Keyword(s):  
Brachial Plexus ◽  
Health Sciences ◽  
Consecutive Series ◽  
State University ◽  
Palpable Mass ◽  
Content Type ◽  
Presenting Symptoms ◽  
Louisiana State University ◽  
Neural Sheath ◽  
Fine Print

Object. The authors conducted a retrospective study of 107 consecutive patients with 111 brachial plexus tumors surgically treated at the Louisiana State University Health Sciences Center (LSUHSC). Methods. During a 12-year period, from 1986 to 1998, 371 patients with lesions of the brachial plexus underwent surgery at LSUHSC. Among this group, 107 patients harbored 111 tumors of the brachial plexus. Neural sheath tumors were the most commonly found and included 33 neurofibromas (20 of which were associated with von Recklinghausen disease), 36 schwannomas, and 12 malignant neural sheath tumors. Of the non—neural sheath tumors, 13 were benign and 17 were malignant. Presenting symptoms included pain (59%), palpable mass (52%), paresthesias (30%), and paresis (29%). Anterior supraclavicular (82%) or posterior subscapular (18%) approaches were used to achieve gross-total (79%) or subtotal (21%) resection of tumor. The average follow-up period was 38.3 months or 3.2 years. Seventy percent of patients with benign neural sheath tumors became free from pain postoperatively or reported improvement in their preoperative pain status. Function remained intact or improved in 50% and remained stable postoperatively in another 20% of cases. Preservation of function was more likely in patients who presented intact and in those who had not undergone a previous attempted biopsy procedure or resection than in those in whom such manipulation had occurred. Conclusions. Resection of most plexal tumors is technically feasible and associated with acceptable morbidity and mortality rates.

Operative management of selected brachial plexus lesions

1983 ◽  
Vol 58 (5) ◽  
pp. 631-649 ◽  
Author(s):  
David G. Kline ◽  
Donald J. Judice
Keyword(s):  
Brachial Plexus ◽  
Operative Management ◽  
Significant Loss ◽  
Benign Tumors ◽  
Content Type ◽  
Lower Trunk ◽  
Large Size ◽  
Fine Print ◽  
Better Than

✓ A 12-year operative experience with 171 consecutive patients with severe brachial plexus lesions who had at least 1½ years of follow-up review is analyzed. Selection for and timing of operation was helped by categorization of each individual plexus element as “completely” or “incompletely” injured and as “in continuity” or “not in continuity.” Results for each element could be given a single grade by a system which defined that element's proximal and distal input. For most lesions in continuity, an operative delay of several months is advocated so that intraoperative electrical evaluation can be used. Thus, in 282 gunshot wounded and stretch-injured elements of which 210 were thought to be clinically complete, 63 were spared resection because of nerve action potentials (NAP's) found at intraoperative testing, and 57 recovered function with only neurolysis. Elements resected (120) were confirmed as neurotmetic both by intraoperative electrical and subsequent histological studies. Acceptable results were achieved in 16 of 24 sutures, in 43 of 89 grafts, and in each of seven split repairs. Upper trunk and lateral and posterior cord elements fared better than lower trunk and medial cord lesions unless the latter were shown, with evidence of NAP's, to be regenerating and could be spared resection. Some stretched elements could, however, not be repaired, even though an attempt was made to exclude such cases from operation. Lacerations to the brachial plexus where continuity is lost are best repaired primarily if the injury is sharp; in this series, 14 of 18 elements having such repair recovered, whereas in 37 elements with secondary repair, grafts were often necessary and only 50% recovered function. Although associated with skin lacerations, 17 elements with complete loss were in continuity, and six of these were shown to be regenerating and were not resected. Despite intraneural location, large size, and prior operation, many benign tumors (including neurofibromas) can be removed without significant loss by use of the surgical loupes or microscope and repetitive NAP recording. Surgery for selected brachial plexus lesions is worthwhile.

Self-inflicted submental and transoral gunshot wounds that produce nonfatal brain injuries: management and prognosis

2005 ◽  
Vol 102 (6) ◽  
pp. 1029-1032 ◽  
Author(s):  
J. David Kriet ◽  
Robert B. Stanley ◽  
M. Sean Grady
Keyword(s):  
Brain Injuries ◽  
Suicide Attempts ◽  
Gunshot Wounds ◽  
Neurological Status ◽  
Low Energy ◽  
Outward Appearance ◽  
Content Type ◽  
Type Of Injury ◽  
Fine Print

Object. Penetrating brain injuries caused by self-inflicted gunshot wounds are very often fatal and survivors suffer serious disabilities. Recognition of a possibly more favorable prognosis for a specific type of injury, the submental or transoral handgun or low-energy rifle wound, prompted the authors to review their experience with patients who had attempted suicide in this manner. Methods. The records of 11 consecutive patients seen over a 10-year period (1992–2001) were retrospectively reviewed. Handguns were used by eight patients and .22 caliber rifles by the others. The patients presented with predominantly unilateral frontal brain injuries that required urgent attention. One elderly patient who had made an advance directive concerning care died. All other patients underwent craniotomy and repair of associated ophthalmological and maxillofacial injuries. Follow-up review ranged from 9 months to 3 years, during which time there were no repeated suicide attempts. All but one patient expressed satisfaction with their appearance and returned to a self-sufficient lifestyle. Conclusions. Self-inflicted submental and transoral handgun and low-energy rifle wounds may produce serious but survivable brain injuries if the path of the bullet is limited to the frontal area. Early aggressive management of brain, dural, and craniomaxillofacial injuries should return the patient to a highly functional neurological status and restore an acceptable outward appearance. Outcomes, therefore, appear to be much better for these patients than for most patients with a penetrating brain injury due to a self-inflicted gunshot wound.

Civilian gunshot wounds to the brachial plexus

1989 ◽  
Vol 70 (2) ◽  
pp. 166-174 ◽  
Author(s):  
David G. Kline
Keyword(s):  
Brachial Plexus ◽  
Gunshot Wounds ◽  
Suture Repair ◽  
Loss Of Function ◽  
Content Type ◽  
Lower Trunk ◽  
Operative Indications ◽  
Grade 3 ◽  
Early Regeneration ◽  
Fine Print

✓ Many gunshot wounds (GSW's) to the brachial plexus do not improve spontaneously with time and are therefore candidates for surgery. Over an 18-year period, 141 patients with GSW's were evaluated, 90 of whom were operated on; 75 of the surgical cases were followed for 2 years or more. Thirty operative patients had initial vascular repair, while eight required thoracotomies. Total plexus palsy was present in 19 of those selected for operation. The average interval between injury and operation was 17 weeks. Six patients required early operation for an expanding aneurysm with progressive neural loss. Persistent complete loss of function in the distribution of one or more elements and/or noncausalgic pain not managed by medications provided the major operative indications. Four patients required sympathectomies for causalgia. Of 166 lesions in continuity believed to be complete, based on clinical examination and electromyography, 48 with preserved intraoperative nerve action potentials (NAP's) were spared resection or were treated with a split repair with excellent eventual results on a weighted grading system. By comparison, only seven of 55 elements believed to have incomplete loss or to be recovering did not have NAP's and required repair. Fifty-three of 98 lesions repaired by grafts and 18 of 26 wounds with suture repair recovered to a Grade 3 level or better. Most elements were in continuity but 14 were found “blown apart” and required repair, usually by grafting. The best outcome was achieved with upper trunk and lateral and posterior cord lesions, but recovery occurred with some C-7 to middle trunk and medial cord to median repairs. Results with lower trunk and most medial cord lesions were poor unless early regeneration was proved by operative NAP's, in which case either neurolysis or split repair could be performed. Surgery is warranted for selected GSW's to the plexus.

Intrapelvic and thigh-level femoral nerve lesions: management and outcomes in 119 surgically treated cases

2004 ◽  
Vol 100 (6) ◽  
pp. 989-996 ◽  
Author(s):  
Daniel H. Kim ◽  
Judith A. Murovic ◽  
Robert L. Tiel ◽  
David G. Kline
Keyword(s):  
Femoral Nerve ◽  
Gunshot Wounds ◽  
Nerve Lesion ◽  
Cystic Lesions ◽  
State University ◽  
Nerve Lesions ◽  
Content Type ◽  
Louisiana State University ◽  
Injury Mechanisms ◽  
Fine Print

Object. The authors present a retrospective analysis of 119 surgically treated femoral nerve lesions at intrapelvic and thigh levels seen at the Louisiana State University Health Sciences Center. Methods. Femoral nerve lesions treated between 1967 and 2000, (89 traumatic injuries and 30 tumors and cystic lesions) were evaluated for injury mechanisms, resulting lesions, surgical management, and postoperative functional outcomes by using retrospective chart reviews. The most common injury mechanism was iatrogenic (52 cases), which occurred after hernia and hip operations (10 each), followed by arterial bypass and gynecological procedures (eight each), angiography (seven), abdominal surgery (five), appendectomy (two), a laparoscopy, and a lumbar sympathectomy. Other injury mechanisms included hip or pelvic fractures (19), gunshot wounds (10), and lacerations (eight). The 30 femoral nerve tumors and cystic lesions consisted of neurofibromas (16), schwannomas (nine), ganglionic cysts (two), neurogenic sarcomas (two), and a leiomyosarcoma. Forty-four patients underwent neurolysis. Some had recordable nerve action potentials (NAPs) across their lesions in continuity, despite severe distal loss. Others with recordable NAPs had mild loss, but also experienced a pain problem, which was helped in some by neurolysis. In 36 patients, in whom repairs were performed using long sural grafts for mostly proximal pelvic-level injuries, recovery of useful function occurred. Eight of nine thigh-level suture repairs led to improvement to good functional levels. Most of the tumors and cystic lesions were resected, with preservation of preoperative function. Conclusions. The majority of femoral nerve injuries resulted in lesions in continuity, and intraoperative NAP recordings were essential in evaluating axonal regeneration across these lesions. Despite severe and frequently proximal injury levels requiring repairs with long grafts, femoral nerve lesion repairs resulted in good functional recovery.

MANAGEMENT OF ONE HUNDRED SEVENTY-ONE OPERATIVE AND NONOPERATIVE OBSTETRICAL BIRTH PALSIES AT THE LOUISIANA STATE UNIVERSITY HEALTH SCIENCES CENTER

Neurosurgery ◽  
2009 ◽  
Vol 65 (suppl_4) ◽  
pp. A67-A73 ◽  
Author(s):  
Yaser Badr ◽  
Shaun O'Leary ◽  
David G. Kline
Keyword(s):  
Brachial Plexus ◽  
Brachial Plexus Injury ◽  
Surgical Intervention ◽  
Pediatric Neurosurgery ◽  
Health Sciences ◽  
Shoulder Function ◽  
State University ◽  
Louisiana State University ◽  
Selective Approach

Abstract OBJECTIVE The management of obstetrical brachial plexus injury, often called birth palsy, remains one of the most controversial topics in pediatric neurosurgery. Most birth palsies have acceptable spontaneous recoveries, whereas only a minority require surgical intervention. A selective approach for surgery was used in this Louisiana State University Health Sciences Center (LSUHSC) series, for which the operative rate was 9%. At LSUHSC, the patient with obstetrical brachial plexus injury is followed for 6 to 9 months before surgery, which is performed if there is no satisfactory biceps and/or shoulder function. METHODS This is a retrospective analysis of 169 patients with 171 palsies referred to LSUHSC for possible surgery. There were 76 patients with 77 birth palsies managed operatively and nonoperatively at LSUHSC between 1975 and 1991. An additional 93 patients with 94 palsies who were managed between 1992 and 2003 were included in this analysis. The results of initial and follow-up examinations using Eng's criteria for impairment ratings (IRs) were available for 151 of 171 (88%) nonoperative and operative obstetrical brachial plexus injuries managed between 1975 and 2001. RESULTS Fifty-two percent of the nonoperative patients evaluated at an initial visit had an IR of 4 or 5, which represents very poor function by comparison to IR of 1 in the Eng scale, which represents almost no abnormality. The percentage of patients in this category (4–5) improved to 30% after follow-up visits. For the 16 operative cases, the initial and follow-up percentages of patients with IRs of 4 or 5 were 67% and 22%, respectively. Ultimately, 47% of the nonoperative patients achieved a grade 2 IR after follow-up compared with 17% of the operative patients. CONCLUSION Using this selective approach at LSUHSC, in which the operative rate was 9%, acceptable outcomes were obtained both in patients not having surgery and also in those having surgical intervention.

Surgical management and outcome in patients with radial nerve lesions

2001 ◽  
Vol 95 (4) ◽  
pp. 573-583 ◽  
Author(s):  
Daniel H. Kim ◽  
Andrew C. Kam ◽  
Padmavathi Chandika ◽  
Robert L. Tiel ◽  
David G. Kline
Keyword(s):  
Surgical Management ◽  
Radial Nerve ◽  
Gunshot Wounds ◽  
Suture Repair ◽  
Content Type ◽  
Louisiana State University ◽  
Internal Neurolysis ◽  
End To End ◽  
Grade 3 ◽  
Fine Print

Object. The goal of this paper was to review surgical management and outcomes in patients treated for radial nerve (RN) lesions at Louisiana State University Health Sciences over a period of 30 years. Methods. Two hundred sixty patients with RN injuries were evaluated. The most common mechanisms of injuries involving the RN included fracture of the humerus, laceration, blunt contusions, and gunshot wounds. One hundred and eighty patients (69%) underwent surgery. Lesions not in continuity required primary or secondary end-to-end suture repairs or graft repairs. With the use of direct intraoperative nerve action potential recording, RN injuries in which the lesion was in continuity required external or internal neurolysis or resection of the lesion followed by end-to-end suture or graft repair. A minimum of 1.5 years follow-up review was available in 90% of the patients who underwent surgery. Motor function recovery to Grade 3 or better was observed in 10 (91%) of 11 patients who underwent primary suture repair, 25 (83%) of 30 who underwent secondary suture repair, 43 (80%) of 54 who received graft repair, and 63 (98%) of 64 in whom neurolysis was performed. Sixteen (71%) of 21 patients with superficial sensory RN injury achieved satisfactory pain relief after complete resection of a neuroma or neurolysis. Conclusions. This study clearly demonstrates that excellent functional recovery can be achieved with proper surgical management of RN injuries.

Tumors of the brachial plexus

2007 ◽  
Vol 22 (6) ◽  
pp. 1-6 ◽  
Author(s):  
Sunit Das ◽  
Aruna Ganju ◽  
Robert L. Tiel ◽  
David G. Kline
Keyword(s):  
Brachial Plexus ◽  
Surgical Approach ◽  
Health Sciences ◽  
State University ◽  
Louisiana State University ◽  
Clinical Challenge ◽  
Complex Anatomy

✓Tumors of the brachial plexus are relatively rare and present a clinical challenge for the neurosurgeon. The management of these tumors therefore requires not only an understanding of the complex anatomy of the brachial plexus but also an appreciation of the appropriate surgical approach to the various tumors that may be encountered. Over a 30-year period (1969–1999), 226 patients with brachial plexus tumors were evaluated and surgically treated by the senior authors (R.L.T., D.G.K.). In the present paper they review the most common benign and malignant brachial plexus tumors and discuss management and surgical principles established through their experience at the Louisiana State University Health Sciences Center.

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