Resorbable posterolateral graft containment in a rabbit spinal fusion model

2002 ◽  
Vol 97 (4) ◽  
pp. 460-463 ◽  
Author(s):  
Ashley R. Poynton ◽  
Fengyu Zheng ◽  
Emre Tomin ◽  
Joseph M. Lane ◽  
G. Bryan Cornwall
Keyword(s):  
Spinal Fusion ◽  
Demineralized Bone Matrix ◽  
Bone Matrix ◽  
Autologous Bone Graft ◽  
Fusion Model ◽  
Content Type ◽  
Lumbar Spinal ◽  
Posterolateral Spinal Fusion ◽  
Mass Volume ◽  
Fine Print

Object. The authors studied the effect of a resorbable graft containment device in a rabbit posterolateral lumbar spinal fusion model. Methods. Twenty rabbits were divided into four groups: autologous bone graft (ABG), ABG with the MacroPore containment device (ABG + MP), demineralized bone matrix (DBM), and DBM with the containment device (DBM + MP). Fusion mass was assessed at 6 weeks with high-resolution radiography and volumetric computerized tomography. The graft containment device was associated with alteration of the fusion mass structure and significant enhancement of fusion mass volume (ABG versus ABG + MP, p = 0.027; DBM versus DBM + MP, p = 0.043). Conclusions. A bioabsorbable protective graft containment device successfully enhanced posterolateral spinal fusion mass volume.

P34. 5-Lipoxygenase Inhibition and a Novel Rat Posterolateral Lumbar Spinal Fusion Model Using Homologous Rat Demineralized Bone Matrix

2009 ◽  
Vol 9 (10) ◽  
pp. 132S-133S
Author(s):  
Praveen Yalamanchili ◽  
Michael Vives ◽  
J. Patrick O'Connor ◽  
Mitchell Reiter ◽  
Catherine Cunningham ◽  
...  
Keyword(s):  
Spinal Fusion ◽  
Demineralized Bone Matrix ◽  
Bone Matrix ◽  
Lumbar Spinal Fusion ◽  
Fusion Model ◽  
Lipoxygenase Inhibition ◽  
Lumbar Spinal ◽  
Demineralized Bone

Evaluation of a new formulation of demineralized bone matrix putty in a rabbit posterolateral spinal fusion model

2014 ◽  
Vol 14 (9) ◽  
pp. 2155-2163 ◽  
Author(s):  
Paul D. Kiely ◽  
Antonio T. Brecevich ◽  
Fadi Taher ◽  
Joseph T. Nguyen ◽  
Frank P. Cammisa ◽  
...  
Keyword(s):  
Spinal Fusion ◽  
Demineralized Bone Matrix ◽  
Bone Matrix ◽  
Fusion Model ◽  
New Formulation ◽  
Posterolateral Spinal Fusion ◽  
Demineralized Bone

The effects of dexamethasone on bone fusion in an experimental model of posterolateral lumbar spinal arthrodesis

2001 ◽  
Vol 94 (1) ◽  
pp. 76-81 ◽  
Author(s):  
Paul D. Sawin ◽  
Curtis A. Dickman ◽  
Neil R. Crawford ◽  
M. Stephen Melton ◽  
William D. Bichard ◽  
...  
Keyword(s):  
Tensile Strength ◽  
Bone Graft ◽  
Spinal Fusion ◽  
Experimental Model ◽  
Content Type ◽  
Bone Fusion ◽  
Group 12 ◽  
Spinal Arthrodesis ◽  
Lumbar Spinal ◽  
Fine Print

Object. The use of corticosteroid agents during the healing phase after spinal arthrodesis remains controversial. Although anecdotal opinion suggests that corticosteroids may inhibit bone fusion, such an effect has not been substantiated in clinical trials or laboratory investigations. This study was undertaken to delineate the effect of exogenous corticosteroid administration on bone graft incorporation in an experimental model of posterolateral lumbar fusion. Methods. An established, well-validated model of lumbar intertransverse process spinal fusion in the rabbit was used. Twenty-four adult New Zealand white rabbits underwent L5–6 bilateral posterolateral spinal fusion in which autogenous iliac crest bone graft was used. After surgery, the animals were randomized into two treatment groups: a control group (12 rabbits) that received intramuscular injections of normal saline twice daily and a dexamethasone group (12 rabbits) that received intramuscular dexamethasone (0.05 mg/kg) twice daily. After 42 days, the animals were killed and the integrity of the spinal fusions was assessed by radiography, manual palpation, and biomechanical testing. In seven (58%) of the 12 control rabbits, solid posterolateral fusion was achieved. In no dexamethasone-treated rabbits was successful fusion achieved (p = 0.003). Tensile strength and stiffness of excised spinal segments were significantly lower in dexamethasone-treated animals than in control animals (tensile strength 91.4 ± 30.6 N and 145.3 ± 48.2, respectively, p = 0.004; stiffness 31.4 ± 11.6 and 45.0 ± 15.2 N/mm, respectively, p = 0.02). Conclusions. The corticosteroid agent dexamethasone inhibited bone graft incorporation in a rabbit model of single-level posterolateral lumbar spinal fusion, inducing a significantly higher rate of nonunion, compared with that in saline-treated control animals.

A Comparison of Commercially Available Demineralized Bone Matrix with and without Human Mesenchymal Stem Cells in a Rodent Spinal Fusion Model

2014 ◽  
Vol 14 (11) ◽  
pp. S87
Author(s):  
Tetsuo Hayashi ◽  
Jeffrey C. Wang ◽  
Elizabeth L. Lord ◽  
Akinobu Suzuki ◽  
Shinji Takahashi ◽  
...  
Keyword(s):  
Stem Cells ◽  
Mesenchymal Stem Cells ◽  
Spinal Fusion ◽  
Demineralized Bone Matrix ◽  
Bone Matrix ◽  
Human Mesenchymal Stem Cells ◽  
Fusion Model ◽  
Demineralized Bone

Biomechanical and Radiographic Comparison of Demineralized Bone Matrix, and a Coralline Hydroxyapatite in a Rabbit Spinal Fusion Model

2009 ◽  
Vol 25 (3) ◽  
pp. 195-215 ◽  
Author(s):  
Robert A. Dodds ◽  
Amanda M. York-Ely ◽  
Rasa Zhukauskas ◽  
Travis Arola ◽  
John Howell ◽  
...  
Keyword(s):  
Spinal Fusion ◽  
Demineralized Bone Matrix ◽  
Bone Matrix ◽  
Fusion Model ◽  
Coralline Hydroxyapatite ◽  
Demineralized Bone
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