scholarly journals Novel results on a fixed function and their application based on the best approximation of the treatment plan for tumour patients getting intensity modulated radiation therapy (IMRT)

2019 ◽  
Vol 68 (3) ◽  
pp. 223 ◽  
Author(s):  
P Dhawan ◽  
J Kaur ◽  
V Gupta
Keyword(s):  
Radiation Therapy ◽  
Best Approximation ◽  
Treatment Plan ◽  
Intensity Modulated Radiation Therapy ◽  
Intensity Modulated ◽  
The Best Approximation ◽  
Fixed Function

A new Monte Carlo-based treatment plan optimization approach for intensity modulated radiation therapy

2015 ◽  
Vol 60 (7) ◽  
pp. 2903-2919 ◽  
Author(s):  
Yongbao Li ◽  
Zhen Tian ◽  
Feng Shi ◽  
Ting Song ◽  
Zhaoxia Wu ◽  
...  
Keyword(s):  
Monte Carlo ◽  
Radiation Therapy ◽  
Treatment Plan ◽  
Intensity Modulated Radiation Therapy ◽  
Optimization Approach ◽  
Intensity Modulated ◽  
Plan Optimization ◽  
Treatment Plan Optimization

Intensity modulated radiation therapy treatment plan optimization

Top ◽  
2008 ◽  
Vol 16 (2) ◽  
pp. 215-243 ◽  
Author(s):  
H. Edwin Romeijn ◽  
James F. Dempsey
Keyword(s):  
Radiation Therapy ◽  
Treatment Plan ◽  
Intensity Modulated Radiation Therapy ◽  
Intensity Modulated ◽  
Plan Optimization ◽  
Treatment Plan Optimization ◽  
Therapy Treatment

scholarly journals Proton Versus Intensity-Modulated Radiation Therapy: First Dosimetric Comparison for Total Scalp Irradiation

2019 ◽  
Vol 6 (3) ◽  
pp. 19-26
Author(s):  
Ankur Markand Sharma ◽  
Emily Kowalski ◽  
Nathan McGovern ◽  
Mingyao Zhu ◽  
Mark Vikas Mishra
Keyword(s):  
Radiation Therapy ◽  
Organs At Risk ◽  
Treatment Plan ◽  
Intensity Modulated Radiation Therapy ◽  
High Dose ◽  
Proton Radiation ◽  
Dosimetric Comparison ◽  
Intensity Modulated ◽  
Volumetric Arc Therapy ◽  
Cutaneous Lymphomas

Abstract Purpose: Total scalp irradiation (TSI) is used to treat malignancies of the scalp and face, including angiosarcomas, nonmelanoma skin cancers, and cutaneous lymphomas. Owing to the irregularity of the scalp contour and the presence of underlying critical organs at risk (OARs), radiation planning is challenging and technically difficult. To address these complexities, several different radiation therapy techniques have been used. These include the combined lateral photon-electron technique (3DRT), intensity-modulated radiation therapy (IMRT)/volumetric arc therapy (VMAT), helical tomotherapy (HT), and mold-based high-dose-rate brachytherapy (HDR BT). However, the use of proton radiation therapy (PRT) has never been documented. Materials and Methods: A 71-year-old, immunosuppressed man presented with recurrent nonmelanoma skin cancer of the scalp. He was successfully treated at our center with PRT to deliver TSI. A comparative VMAT treatment plan was generated and dose to critical OARs was compared. Results: We present the first clinical case report of PRT for TSI and dosimetric comparison to a VMAT plan. The PRT and VMAT plans provided equivalent target volume coverage; however, the PRT plan significantly reduced dose to the brain, hippocampi, and optical apparatus. Conclusion: TSI planned with PRT is relatively straightforward from a planning perspective and does not require a bolus. It also has the potential to decrease radiation therapy–related toxicity. However, PRT is relatively expensive and not universally available. The uncertainty surrounding the end-range of the proton beam is a consideration. Although there are potential disadvantages to using PRT for TSI, its use should be considered by treating radiation oncologists and referring physicians.

The choice of IMRT for early-stage right breast cancer.

2013 ◽  
Vol 31 (26_suppl) ◽  
pp. 81-81
Author(s):  
Sophia Edwards-Bennett ◽  
Stephen Andrews ◽  
Patrick Francke ◽  
Frank Vicini
Keyword(s):  
Breast Cancer ◽  
Radiation Therapy ◽  
Chest Wall ◽  
Early Stage ◽  
Treatment Plan ◽  
Univariate Analysis ◽  
Surrogate Marker ◽  
Intensity Modulated Radiation Therapy ◽  
Skin Dose ◽  
Intensity Modulated

81 Background: The benefit of Intensity Modulated Radiation Therapy (IMRT) has been established for left breast cancer. However, IMRT is not routinely employed for right breast cancer. The purpose of this study is to (1) compare dosimetric parameters in women with early stage right breast cancer undergoing whole breast radiation therapy using 3-dimensional conformal radiation (3DCRT) versus intensity modulated radiation therapy (IMRT) (2) determine treatment planning and/or anatomical correlates for patients who may benefit from IMRT. Methods: IMRT versus 3DCRT treatment plans were compared for 20 consecutive female patients with early stage (T1-T2 N0M0 ) right breast cancer treated at our center from 1/2012 to 12/2012. The planned target volume (PTV), contoured according to the RTOG atlas guidelines, was prescribed to 46-8-50.4 Gy in 26-28 fractions with PTV coverage goal of ≥ 95 % receiving the prescription dose. Dosimetric and anatomic parameters: % right lung receiving 20 Gy (lung V20), maximum breast dose (Dmax), maximum skin dose (Dmax skin), chest wall separation (CWS) and medial gantry angle (MGA) were determined for each paired treatment plan. Wilcoxon-signed rank test was utilized to compare IMRT and 3DCRT dosimetric parameters. Univariate analysis was used to identify planning or anatomic correlates associated with favorable dosimetric outcomes. Results: The lung V20Gy for IMRT ( 10.86±2.81%) was significantly lower than for 3DCRT (12.92±3.45 %, p < 0.043). IMRT significantly reduced Dmax to 53.79 ± 2.17 Gy from 56.7 ± 2.24 Gy with 3DCRT (p 0.001). 3DCRT yielded significantly higher Dmax skin (33.47±3.21 Gy) than IMRT (24.16 ±2.65 Gy, p< 0.0001). Mean CWS and MGA were 22.4 ± 2.6 cm and 126 ± 5.1° respectively. There was a significant association between CWS and Dmax for 3DCRT (p < 0.026). Conclusions: The most significant impact of IMRT for right breast cancer was the reduction of Dmax and Dmax skin, with a more tempered advantage in the reduction of lung V20. Reduction of maximum breast and skin dose harbors clinical relevance as it relates to acute skin toxicity, long- term fibrosis and adverse cosmetic outcomes. Chest wall separation may be a potential planning surrogate marker to determine which right-sided breast cancer patients may benefit from IMRT.

scholarly journals A dummy-run evaluation of postoperative hypofractionated intensity-modulated radiation therapy (POHIM-RT) trials for cervical cancer

2020 ◽  
Vol 62 (1) ◽  
pp. 149-154
Author(s):  
Won Kyung Cho ◽  
Heejung Kim ◽  
Won Park ◽  
Sang-Won Kim ◽  
Jongwon Kim ◽  
...  
Keyword(s):  
Cervical Cancer ◽  
Quality Assurance ◽  
Radiation Therapy ◽  
Organs At Risk ◽  
Treatment Plan ◽  
Intensity Modulated Radiation Therapy ◽  
Target Volume ◽  
Similarity Coefficients ◽  
Intensity Modulated ◽  
And Performance

Abstract The postoperative hypofractionated intensity-modulated radiation therapy (POHIM-RT) trial is a phase II study to evaluate toxicity following hypofractionated intensity modulated radiation therapy (IMRT) for cervical cancer. This study describes the results of a benchmark procedure for RT quality assurance of the POHIM-RT trial. Six participating institutions were provided computed tomography for RT planning and an IMRT plan for a sample and were instructed to delineate volumes, create a treatment plan and quality assurance (QA) plan, and submit the results of all procedures. The inter-institutional agreements on RT volume and plan results were evaluated using the kappa value and dice similarity coefficients. The simultaneous truth and performance level estimation (STAPLE) method was employed to generate a consensus target volume. The treatment volumes, organs-at-risk volumes, and results of the RT plan and QA reported by the institutions were acceptable and adhered well to the protocol. In terms of clinical target volume (CTV) delineation, there were differences between the institutions, particularly in vaginal cuff and paracolpium subsites. Consensus CTV was generated from the collected CTVs with the STAPLE method. The participating institutions showed considerable agreement regarding volume, dose and QA results. To improve CTV agreement in CTV, we provided feedback with images of the consensus target volume and detailed written guidelines for specific subsites that were the most heterogeneous.

Dosimetric comparison of volumetric modulated arc therapy and intensity modulated radiation therapy for anal cancer

2019 ◽  
Vol 19 (2) ◽  
pp. 190-192
Author(s):  
Bing-Hao Chiang ◽  
Kerry Hibbitts ◽  
Heather Ortega ◽  
Terence Herman ◽  
Salahuddin Ahmad
Keyword(s):  
Radiation Therapy ◽  
Treatment Time ◽  
Treatment Plan ◽  
Volumetric Modulated Arc Therapy ◽  
Anal Carcinoma ◽  
Intensity Modulated Radiation Therapy ◽  
Patient Comfort ◽  
Dose Volume Histograms ◽  
Intensity Modulated ◽  
Arc Therapy

AbstractAim:Volumetric modulated arc therapy (VMAT), an extension of intensity modulated radiation therapy (IMRT), employs modifications in gantry rotation speed, machine dose rate and multi-leaf collimator motion to deliver a three-dimensional dose distribution. This study compared VMAT to IMRT for patients with anal carcinoma.Materials and Methods:Sixteen patients previously treated with IMRT were retrospectively selected. Each patient received a total dose of 57·6–63·0 Gy in 1·8 Gy fractions. A single- or double-isocenter multi-arc VMAT treatment plan was generated using Eclipse RapidArc system with the same computed tomography image sets and optimisation constraints used for IMRT. Dose–volume histograms (DVHs) for planning target volumes (PTVs) and organs at risk (OARs), and monitor units (MUs) and beam on times (BOTs) were used for comparison. Results:IMRT and VMAT plans showed insignificant differences in PTV homogeneity and conformity and sparing hips and bowel. VMAT required fewer mean MU and shorter BOT per plan (1,597 MU, 2·66 min) compared to IMRT (2,571 MU, 4·29 min) with p < 0·0001. Conclusions:Fewer MU and shorter BOT for VMAT may decrease the damage from secondary radiation and treatment delivery uncertainty due to intra-fraction tumour motion, leading to higher machine throughput and improving patient comfort, with less treatment time.

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