scholarly journals HEPCIDIN AS A POSSIBLE MARKER IN DETERMINATION OF MALIGNANCY DEGREE AND SENSITIVITY OF BREAST CANCER CELLS TO CYTOSTATIC DRUGS

2016 ◽  
Vol 38 (2) ◽  
pp. 84-88 ◽  
Author(s):  
T M Yalovenko ◽  
I M Todor ◽  
N Yu Lukianova ◽  
V F Chekhun
Keyword(s):  
Breast Cancer ◽  
Iron Content ◽  
Drug Resistant ◽  
Malignant Phenotype ◽  
Walker 256 Carcinosarcoma ◽  
Resistant Phenotype ◽  
Walker 256 ◽  
Drug Resistant Phenotype

Aim: To investigate the role of hepcidin (Hepc) in the formation of cells malignant phenotype in vitro and its expression in the dyna mics of growth of Walker-256 carcinosarcoma with different sensitivity to doxorubicin (Dox). Materials and Methods: The cell lines used in the analysis included T47D, MCF-7, MDA-MB-231, MDA-MB-468, MCF/CP, and MCF/Dox. Hepc expression was studied by immunocytochemical method. “Free” iron content was determined by EPR spectroscopy. Determination of Hepc expression in homogenates of tumor tissue and in blood serum of rats with Dox-sensitive and -resistant Walker-256 carcinosarcoma was performed. Results: It was found that Hepc levels in breast cancer (BC) cells with high degree of malignancy (MDA-MB-231, MDAMB-468) and drug-resistant phenotype (MCF/CP, MCF/Dox) were by 1.5–2 times higher (p < 0.05) in comparison with sensitive and less malignant BC cells. The development of drug-resistant phenotype in Walker-256 carcinosarcoma cells was accompanied by increasing of Hepc and “free” iron content (by 2.4 and 1.2 times, respectively). Conclusion: The data of in vitro and in vivo research evidenced on involvement of Hepc in formation of BC cells malignant phenotype and their resistance to Dox.

ABCB1/MDR1 contributes to the anticancer drug-resistant phenotype of IPH-926 human lobular breast cancer cells

2012 ◽  
Vol 315 (2) ◽  
pp. 153-160 ◽  
Author(s):  
Till Krech ◽  
Elisa Scheuerer ◽  
Robert Geffers ◽  
Hans Kreipe ◽  
Ulrich Lehmann ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Cancer Cells ◽  
Anticancer Drug ◽  
Breast Cancer Cells ◽  
Drug Resistant ◽  
Lobular Breast Cancer ◽  
Resistant Phenotype ◽  
Drug Resistant Phenotype

mdr1 Ribozyme mediated reversal of the multi-drug resistant phenotype in human lung cell lines

1996 ◽  
Vol 19 (3) ◽  
pp. 199-205 ◽  
Author(s):  
Carmel Daly ◽  
Seamus Coyle ◽  
Shirley McBride ◽  
Lorraine O'Driscoll ◽  
Noel Daly ◽  
...  
Keyword(s):  
Cell Lines ◽  
Human Lung ◽  
Drug Resistant ◽  
Resistant Phenotype ◽  
Drug Resistant Phenotype

scholarly journals Antitumor mechanism of evodiamine, a constituent from Chinese herb Evodiae fructus , in human multiple-drug resistant breast cancer NCI/ADR-RES cells in vitro and in vivo

2005 ◽  
Vol 26 (5) ◽  
pp. 968-975 ◽  
Author(s):  
Cho-Hwa Liao ◽  
Shiow-Lin Pan ◽  
Jih-Hwa Guh ◽  
Ya-Ling Chang ◽  
Hui-Chen Pai ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Chinese Herb ◽  
Multiple Drug ◽  
Drug Resistant ◽  
Multiple Drug Resistant

scholarly journals Curcumin augments cytostatic and anti-invasive effects of mitoxantrone on carcinosar-coma cells in vitro

2016 ◽  
Vol 63 (3) ◽  
Author(s):  
Marcin Luty ◽  
Edyta Kwiecień ◽  
Magdalena Firlej ◽  
Anna Łabędź-Masłowska ◽  
Milena Paw ◽  
...  
Keyword(s):  
Curcuma Longa ◽  
Drug Resistant ◽  
Additive Effects ◽  
Inhibitory Effects ◽  
Curcumin Treatment ◽  
Invasive Potential ◽  
Effective Doses ◽  
Walker 256

Numerous adverse effects limit the applicability of mitoxantrone for the treatment of drug-resistant tumors, including carcinosarcoma. Here, we estimated the additive effects of mitoxantrone and curcumin, a plant-derived biomolecule isolated from Curcuma longa, on the neoplastic and invasive potential of carcinosarcoma cells in vitro. Curcumin augmented cytostatic, cytotoxic and anti-invasive effects of mitoxantrone on Walker-256 cells. It also strengthened inhibitory effects of mitoxantrone on the motility of drug-resistant Walker-256 cells that had retained the viability after long-term mitoxantrone/curcumin treatment. Thus, curcumin reduces the effective doses of mitoxantrone and augments its interference with the invasive potential of drug-resistant carcinosarcoma cells.

scholarly journals Pivotal role of NAMPT in the switch of melanoma cells toward an invasive and drug-resistant phenotype

2018 ◽  
Vol 32 (5-6) ◽  
pp. 448-461 ◽  
Author(s):  
Mickaël Ohanna ◽  
Mickaël Cerezo ◽  
Nicolas Nottet ◽  
Karine Bille ◽  
Robin Didier ◽  
...  
Keyword(s):  
Melanoma Cells ◽  
Pivotal Role ◽  
Drug Resistant ◽  
Resistant Phenotype ◽  
Drug Resistant Phenotype
Sign in / Sign up

Export Citation Format

Share Document