Comparison of Post Operative Clinical Outcomes Between “ Made in India” TTK Chitra Mechanical Heart Valve versus St Jude Mechanical Heart in Valve Replacement Surgery

Abstract Objective To study the effect of nicoumalone on embryogenesis in women who have undergone mechanical heart valve replacement surgery. Design It is a retrospective study done at Sri Venkateswara Institute of Medical Sciences (SVIMS), Tirupati. Results Total 28 pregnancies were reported in 12 women with mechanical heart valve prostheses. Of these, 19 were live births, 9 abortions, and no stillbirths and miscarriages were noted in pregnant women. There were 11 hemorrhagic, 3 neurologic, 2 thromboembolic, and 1 stuck valve complications observed in mothers; and 2 low birth weights, 2 pneumonia, and 1 jaundice observed in the child. Conclusion There were no abnormalities observed in children whose mothers were taking nicoumalone throughout pregnancy based on echo results and clinical examination.

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Retrospective investigation of anticoagulant complications in long term after mechanical heart valve replacement surgery in Turkey

10.32592/ircmj.2021.23.1.13 ◽

2020 ◽

Keyword(s):

Emergency Department ◽

Valve Replacement ◽

Heart Valve ◽

Mechanical Heart Valve ◽

Heart Valve Replacement ◽

Factors Affecting ◽

Replacement Surgery ◽

The Mean ◽

Valve Replacement Surgery

Background: Patients with mechanical heart valve replacement surgery (MHVRS) should be followed up in terms of prosthetic valve-related and open heart surgery complications. This study aimed to determine the anticoagulant complications in long term in patients with MHVRS. Methods: This retrospective and descriptive study was conducted in a university hospital, İzmir, Turkey. The data were collected from July to December 2019. In total, 73 patients referring for regular check-ups to the hospital with intervals not exceeded more than 90 days, and those who had international normalized ratio (INR) measurements for January-April-July-October 2018 were included in this study. Results: The mean age of the patients was obtained at 58.98±12.89 years, and 53.4% (n=39) of the cases were male. Moreover, the mean follow-up period was estimated at 65.98±28.47 months. According to the results, complications developed in 60 patients (82.2%). The first hospitalized unit was the emergency department. The factors affecting the development of complications after MHVRS were evaluated, and a difference was found regarding gender (X2=6.18, P=0.013), comorbidities (X2=25.58, P=0.018), and monthly referral for regular check-ups to the hospital (X2=5.20, P=0.023). There was no relationship between the INR levels and the development of complications. Furthermore, the results of evaluating the factors affecting the number of hospitalizations after MHVRS revealed that monthly referral to hospital for check-ups (t=3.18, P=0.002) and history of previous valve surgery (Z=201.00, P=0.03) affected the number of hospitalizations. Conclusions: It was observed that patients frequently refer to the emergency department and struggled with various complications. Moreover, it was found that the patients had frequent bleeding and refer to the emergency service repeatedly. Accordingly, there is a need for interventional studies to reduce postoperative complications and provide the therapeutic INR level.

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Effect of post‐operative anticoagulation management in patients who have undergone On‐X mechanical heart valve replacement surgery on post‐discharge warfarin therapy

Journal of Clinical Pharmacy and Therapeutics ◽

10.1111/jcpt.13164 ◽

2020 ◽

Vol 45 (4) ◽

pp. 767-773

Author(s):

Eun Min Oh ◽

Ok Sang Lee ◽

Bo Min Jang ◽

Sohyun Park ◽

Eun Jeong Cho ◽

...

Keyword(s):

Valve Replacement ◽

Heart Valve ◽

Warfarin Therapy ◽

Mechanical Heart Valve ◽

Heart Valve Replacement ◽

Anticoagulation Management ◽

Post Discharge ◽

Replacement Surgery ◽

Valve Replacement Surgery

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Postconditioning the Human Heart with Adenosine in Heart Valve Replacement Surgery

The Annals of Thoracic Surgery ◽

10.1016/j.athoracsur.2006.12.031 ◽

2007 ◽

Vol 83 (6) ◽

pp. 2066-2072 ◽

Cited By ~ 31

Author(s):

Zhen-Xiao Jin ◽

Jing-Jun Zhou ◽

Mei Xin ◽

Dao-Rong Peng ◽

Xi-Ming Wang ◽

...

Keyword(s):

Valve Replacement ◽

Heart Valve ◽

Human Heart ◽

Heart Valve Replacement ◽

Replacement Surgery ◽

Valve Replacement Surgery

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De Ritis ratio as a significant prognostic factor of international normalized ratio ≥4 in the initial 10 days of warfarin therapy

Biomarkers in Medicine ◽

10.2217/bmm-2019-0033 ◽

2019 ◽

Vol 13 (18) ◽

pp. 1599-1607

Author(s):

Yide Cao ◽

Ganyi Chen ◽

Huangshu Li ◽

Yafeng Liu ◽

Zhonghao Tao ◽

...

Keyword(s):

Valve Replacement ◽

Heart Valve ◽

Warfarin Therapy ◽

Anticoagulation Therapy ◽

International Normalized Ratio ◽

Heart Valve Replacement ◽

Significant Prognostic Factor ◽

Replacement Surgery ◽

The Relationship ◽

Valve Replacement Surgery

Aim: To assess the relationship between the De Ritis ratio on admission and warfarin sensitivity in the initial 10 days of anticoagulation therapy. Methods: We retrospectively reviewed data from 906 patients who underwent heart valve replacement surgery. Results: A De Ritis ratio of 1.19 was identified as the optimal cutoff according to the ROC curve. Patients with a high De Ritis ratio achieved an international normalized ratio (INR) ≥4 more easily and earlier than those with a low De Ritis ratio in the initial 10 days of warfarin therapy. Multivariate analysis showed that a high De Ritis ratio was an independent predictor of an INR ≥4 (HR: 2.567; p < 0.001). Conclusion: A De Ritis ratio ≥1.19 on admission was significantly associated with an INR ≥4 in the initial 10 days of warfarin therapy among patients underwent heart valve replacement surgery.

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