Neutralization in vitro of Mouse Leukemia Virus by Specific Immune Serum. Importance of Virus Titration.

1965 ◽  
Vol 119 (2) ◽  
pp. 420-427 ◽  
Author(s):  
L. Gross
Keyword(s):  
Leukemia Virus ◽  
Immune Serum ◽  
Mouse Leukemia ◽  
Virus Titration ◽  
Mouse Leukemia Virus

Eine Komplementbindungsreaktion zum Nachweis der bei Leukämieviren verschiedener Säuger vorkommenden gemeinsamen antigenen Komponente

1970 ◽  
Vol 25 (9) ◽  
pp. 1029-1036 ◽  
Author(s):  
Werner Schäfer ◽  
Jens Lange ◽  
Liselotte Pister ◽  
Eveline Seifert ◽  
Fernando de Noronha ◽  
...  
Keyword(s):  
Tissue Culture ◽  
Cancer Cells ◽  
Human Cancer ◽  
Leukemia Virus ◽  
Mouse Leukemia ◽  
Human Cancer Cells ◽  
Mouse Leukemia Virus ◽  
Bovine Leukosis

By immunization of a rabbit with purified gs-antigen from mouse leukemia virus (MLV) a potent antiserum (R-gs-serum) was obtained, which reacts specifically with gs-antigen of MLV.In cat leukemia virus (KLV) two types of antigens, probably both group specific, could be demonstrated with anti-KLV-sera by Ouchterlony test. One of these was shown with MLV-sera to be identical with a MLV-gs-antigen component. This antigen occurring in both viruses is called gsinterspecies (interspec.) antigen.R-gs-serum allowed to detect gs-interspec. antigen also by the more sensitive CF-test. [Lispa (leukemia virus interspec. antigen) CF-test]. Preliminary experiments with this test indicated that bovine leukosis as well as human cancer cells can produce an agent in tissue culture which is serologically related to MLV.

scholarly journals Antigenic modulation of Friend virus erythroleukemic cells in vitro by serum from mice with dormant erythroleukemia.

1977 ◽  
Vol 146 (2) ◽  
pp. 520-534 ◽  
Author(s):  
E V Genovesi ◽  
P A Marx ◽  
E F Wheelock
Keyword(s):  
Cell Surface ◽  
Leukemia Virus ◽  
Surface Antigens ◽  
Immune Serum ◽  
Mouse Serum ◽  
Cell Surface Antigens ◽  
Antigenic Modulation ◽  
In Cells ◽  
Erythroleukemic Cells

Friend leukemia virus (FLV) erythroleukemic cells cultured in medium containing FLV-immune serum from dormant FLV-infected mice undergo modulation of FLV cell surface antigens. Modulation was determined by an increased resistance to FLV antibody-mediated complement-dependent lysis and was associated temporally with the capping of FLV-immune complexes at the cell surface. Modulated cells regained their susceptibility to FLV antibody-mediated complement-dependent lysis when transferred to medium containing normal mouse serum. After 48 h of culture in FLV-immune serum, 26% of the FLV erythroleukemic cells were devoid of FLV cell surface antigens as demonstrated by immunofluoresence. Antigenic modulation occurred to a greater extent in cells maintained in logarithmic growth than in cells in GO or resting phase. FLV-antigenic modulation is discussed as a possible mechanism by which antibody induces and maintains FLV-transformed cells in a dormant state.

Malignant transformation in a tissue culture infected with a mouse leukemia virus

1968 ◽  
Vol 23 (1-2) ◽  
pp. 169-174 ◽  
Author(s):  
J. G. Sinkovics ◽  
F. Gy�rkey ◽  
Glenda F. Groves ◽  
Phyllis Gy�rkey
Keyword(s):  
Tissue Culture ◽  
Malignant Transformation ◽  
Leukemia Virus ◽  
Mouse Leukemia ◽  
Mouse Leukemia Virus

scholarly journals Inheritance of Susceptibility to Friend Mouse Leukemia Virus

1969 ◽  
Vol 4 (6) ◽  
pp. 837-843 ◽  
Author(s):  
Takeshi Odaka ◽  
Michio Matsukura
Keyword(s):  
Leukemia Virus ◽  
Mouse Leukemia ◽  
Mouse Leukemia Virus

A System of Tissue Cultures for the Study of a Mouse Leukemia Virus

1969 ◽  
Vol 119 (1) ◽  
pp. 19-38 ◽  
Author(s):  
J. G. Sinkovics ◽  
G. F. Groves ◽  
B. A. Bertin ◽  
C. C. Shullenberger
Keyword(s):  
Leukemia Virus ◽  
Tissue Cultures ◽  
Mouse Leukemia ◽  
Mouse Leukemia Virus
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