Optimal drug dosing via application of the Contraction Mapping Theorem

2009 ◽  
Vol 42 (12) ◽  
pp. 121-126
Author(s):  
Neil D. Evans
Author(s):  
Seamus D Hogan

This paper derives a general sufficient condition for existence and uniqueness in continuous games using a variant of the contraction mapping theorem applied to mappings from a subset of the real line on to itself. We first prove this contraction mapping variant, and then show how the existence of a unique equilibrium in the general game can be shown by proving the existence of a unique equilibrium in an iterative sequence of games involving such mappings. Finally, we show how a general condition for this to occur is that a matrix derived from the Jacobian matrix of best-response functions has positive leading principal minors, and how this condition generalises some existing uniqueness theorems for particular games. In particular, we show how the same conditions used in those theorems to show uniqueness, also guarantee existence in games with unbounded strategy spaces.


2018 ◽  
Vol 28 (1) ◽  
pp. 123-133 ◽  
Author(s):  
Rajendran Mabel Lizzy ◽  
Krishnan Balachandran

AbstractSufficient conditions for the controllability of nonlinear stochastic fractional boundary control systems are established. The equivalent integral equations are derived for both linear and nonlinear systems, and the control function is given in terms of the pseudoinverse operator. The Banach contraction mapping theorem is used to obtain the result. A controllability result for nonlinear stochastic fractional integrodifferential systems is also attained. Examples are included to illustrate the theory.


Author(s):  
Diego Issicaba ◽  
Jorge Coelho

<p>This paper presents an assessment of the forward-backward sweep load flow method to distribution system analysis. The method is formally assessed using fixed-point concepts and the contraction mapping theorem. The existence and uniqueness of the load flow feasible solution is supported by an alternative argument from those obtained in the literature. Also, the closed-form of the convergence rate of the method is deduced and the convergence dependence of loading is assessed. Finally, boundaries for error values per iteration between iterates and feasible solution are obtained. Theoretical results have been tested in several numerical simulations, some of them presented in this paper, thus fostering discussions about applications and future works.</p>


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