BRINZOLAMIDE-2-HYDROXYPROPYL BETA CYCLODEXTRIN COMPLEX LOADED CHITOSAN NANOGEL FOR OCULAR DRUG DELIVERY

2019 ◽  
Vol 11 (02) ◽  
Keyword(s):  
Drug Delivery ◽  
Ocular Drug Delivery ◽  
Cyclodextrin Complex ◽  
Beta Cyclodextrin ◽  
Hydroxypropyl Beta Cyclodextrin

scholarly journals Doxorubicin·Hydrochloride/Cisplatin-Loaded Hydrogel/Nanosized (2-Hydroxypropyl)-Beta-Cyclodextrin Local Drug-Delivery System for Osteosarcoma Treatment In Vivo

Nanomaterials ◽  
2019 ◽  
Vol 9 (12) ◽  
pp. 1652 ◽  
Author(s):  
Sun Jung Yoon ◽  
Young Jae Moon ◽  
Heung Jae Chun ◽  
Dae Hyeok Yang
Keyword(s):  
Drug Delivery ◽  
Drug Delivery System ◽  
Delivery System ◽  
Local Drug Delivery ◽  
Glycol Chitosan ◽  
Beta Cyclodextrin ◽  
Osa Treatment ◽  
Local Drug Delivery System ◽  
Hydroxypropyl Beta Cyclodextrin

Osteosarcoma (OSA) is a difficult cancer to treat due to its tendency for relapse and metastasis; advanced methods are therefore required for OSA treatment. In this study, we prepared a local drug-delivery system for OSA treatment based on doxorubicin·hydrochloride (DOX·HCl)/cisplatin (CP)-loaded visible light-cured glycol chitosan (GC) hydrogel/(2-hydroxypropyl)-beta-cyclodextrin (GDHCP), and compared its therapeutic efficiency with that of DOX·HCl- and CP-loaded GC hydrogels (GD and GHCP). Because of diffusion driven by concentration gradients in the swollen matrix, the three hydrogels showed sustained releases of DOX·HCl and CP over 7 days, along with initial 3-h bursts. Results of in vitro cell viability and in vivo animal testing revealed that GDHCP had a stronger anticancer effect than GD and GHCP even though there were no significant differences. Body weight measurement and histological evaluations demonstrated that the drug-loaded GC hydrogels had biocompatibility without cardiotoxicity or nephrotoxicity. These results suggested that GDHCP could be a good platform as a local drug-delivery system for clinical use in OSA treatment.

scholarly journals Anticancer effect of dentatin and dentatin-hydroxypropyl-β-cyclodextrin complex on human colon cancer (HT-29) cell line

2017 ◽  
Vol Volume 11 ◽  
pp. 3309-3319 ◽  
Author(s):  
Ashwaq AL-Abboodi ◽  
Abdullah Rasedee ◽  
Ahmad Bustamam Abdul ◽  
Yun Hin Taufiq-Yap ◽  
Wafaa Alkaby ◽  
...  
Keyword(s):  
Colon Cancer ◽  
Cell Line ◽  
Human Colon ◽  
Anticancer Effect ◽  
Cyclodextrin Complex ◽  
Human Colon Cancer ◽  
Beta Cyclodextrin ◽  
Hydroxypropyl Beta Cyclodextrin ◽  
Ht 29
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