Serum Hepcidin And Ferritin Level Changes In Iraqi Adult Patients With Non-Transfusion Dependent Beta-Thalassemia Major And Intermedia

2020 ◽  
Vol 13 (01) ◽  
Keyword(s):  
Ferritin Level ◽  
Thalassemia Major ◽  
Adult Patients ◽  
Beta Thalassemia ◽  
Beta Thalassemia Major ◽  
Serum Hepcidin

scholarly journals BETA THALASSEMIA MAJOR IN A DEVELOPING COUNTRY: EPIDEMIOLOGICAL, CLINICAL AND EVOLUTIONARY ASPECT

2013 ◽  
Vol 5 (1) ◽  
pp. e2013002 ◽  
Author(s):  
Mohamed Bejaoui ◽  
Naouel Guirat
Keyword(s):  
Low Income ◽  
Ferritin Level ◽  
Thalassemia Major ◽  
Small Towns ◽  
Infectious Complications ◽  
Beta Thalassemia ◽  
North West ◽  
Beta Thalassemia Major ◽  
The North ◽  
Mediterranean Countries

Beta-thalassemia major (TM) remains to be one of the major health problems particularly in developing countries. Tunisia is a part of the Mediterranean countries mostly affected by this disease which is highly concentrated in small towns in families with low-income earners. The main objectives of this study are to provide a description of the demographic, clinical features and transfusion-related complications in patients with TM living in Tunisia. A standardized questionnaire was sent to clinicians throughout 33 different medical institutions caring for thalassemic patients. 391 transfusion dependant thalassemic patients with a median age of 10.7 years (range 3 months- 31 years) were included in the study.The majority were originated from the north west of the country .A moderate overload between 1501 and 2500ng/ml was found in 61patients, while 81 patients (26.9%) had ferritin level more than 2500 ng/ml and greater than 5000ng/ml in 21 patients (6.9%). 51 patients died from complications related to their disease. Heart failure was the main cause of death. The incidence of cardiac, endocrine, and infectious complications will be reviewed. Preventive measures such as health education, carrier screening and premarital screening remain the best ways for lowering the incidence of these diseases, which might be reflected in financial saving, social benefits and health benefits.

scholarly journals Influence of Working Memory on Academic Achievement and Quality of Life in Children with Beta-Thalassemia Major

2019 ◽  
Vol 12 (1) ◽  
pp. 76-83 ◽  
Author(s):  
Uni Gamayani ◽  
Ni Luh Meidha Dini Lestari ◽  
Ahmad Rizal Ganiem ◽  
Ramdan Panigoro
Keyword(s):  
Quality Of Life ◽  
Academic Achievement ◽  
Working Memory ◽  
Digit Span ◽  
Ferritin Level ◽  
Memory Function ◽  
Thalassemia Major ◽  
Beta Thalassemia ◽  
Beta Thalassemia Major

Background: Children with beta-thalassemia major may suffer from working memory impairment. For a more refined understanding of this issue, we assessed working memory function in beta-thalassemia children and evaluated its influence on academic achievement and quality of life. Methods: This was a cross-sectional study involving 60 beta-thalassemia children aged 8-12 years. All participants underwent a working memory assessment using the digit span and were interviewed using academic achievement and Indonesian version of PedsQL 4.0 questionnaires. Working memory in beta-thalassemia children significantly influences their quality of life, both directly (β=0.32) and indirectly, through their academic achievement (β=0.639). Longer duration of transfusion (p=0.01) is significantly related to poorer working memory, while lower hemoglobin level (p=0.81) and higher ferritin level (p=0.24) are not significantly associated with working memory. Conclusion: We concluded that working memory influences the quality of life in beta-thalassemia children, both directly and indirectly, through their academic achievement.

scholarly journals PREVALENCE OF HYPOTHYROIDISM, DELAYED PUBERTY AND DIABETES MELLITUS IN PATIENTS OF Β-THALASSEMIA MAJOR

2020 ◽  
Vol 4 (3) ◽  
Author(s):  
Naresh Manne ◽  
Bharat Kumar Gupta ◽  
Sandeep Kumar Yadav ◽  
Saurabh Singhal ◽  
Archana Dubey
Keyword(s):  
Diabetes Mellitus ◽  
Blood Transfusion ◽  
Serum Ferritin ◽  
Serum Ferritin Level ◽  
Ferritin Level ◽  
Thalassemia Major ◽  
Delayed Puberty ◽  
Beta Thalassemia ◽  
Endocrine Disorders ◽  
Beta Thalassemia Major

Background: Beta-Thalassemia is a genetic disorder which is associated with a lot of complications. Frequent blood transfusions result in increased iron deposition in various tissues leading to dysfunction of many vital organs. Endocrine disorders constitute a major part of such complications increasing the morbidity of thalassemia manifold in the affected patients. Methods:  This is a descriptive cross sectional study carried out in 100 diagnosed patients of beta- thalassemia major who had visited the OPD/IPD of Subharti Medical College & affiliated Hospitals, Meerut for routine blood transfusion or for any other complication. Patients were clinically examined and investigated for presence of one or more endocrine disorders on their routine appointments. Results: Endocrine disorders were detected in a total of 82 patients. Diabetes mellitus was detected in 12% patients, hypothyroidism in 36% patients and delayed puberty was found in 72% patients. Mean serum ferritin level was found to be 5831.0±2860.5 ng/ml in beta-thalassemia Major patients, while it was in normal range in control subjects. Conclusion: Research concluded with finding of Delayed puberty (72%), Hypothyroidism (36%) and diabetes mellitus as (12%) in beta thalassemia patients who were on regular blood transfusion therapy.  Iron overload as serum ferritin level was found to be highly raised in all study case. On the basis of our study we recommend that early detection and management protocols for these endocrinopathies may improve the life prospects of beta-thalassemia Major patients. Keywords: Endocrine disorders, Hypothyroidism, Delayed puberty, Diabetes Mellitus Serum ferritin, Thalassemia Major.

Investigation of correlation between H63D and C282Y mutations in HFE gene and serum Ferritin level in beta-thalassemia major patients

2019 ◽  
Vol 26 (4) ◽  
pp. 249-252
Author(s):  
Romina Rahmani ◽  
Parisa Naseri ◽  
Ava Safaroghli-Azar ◽  
Shahriar Tarighi ◽  
Tahereh hosseini ◽  
...  
Keyword(s):  
Serum Ferritin ◽  
Serum Ferritin Level ◽  
Ferritin Level ◽  
Thalassemia Major ◽  
Beta Thalassemia ◽  
Hfe Gene ◽  
Beta Thalassemia Major

Electrocardiographic abnormalities and arrhythmic risk markers in adult patients with beta thalassemia major

2016 ◽  
Vol 221 ◽  
pp. 932-936 ◽  
Author(s):  
Marios Kolios ◽  
Panagiotis Korantzopoulos ◽  
Antonios P. Vlahos ◽  
Eleni Kapsali ◽  
Evangelos Briasoulis ◽  
...  
Keyword(s):  
Thalassemia Major ◽  
Adult Patients ◽  
Beta Thalassemia ◽  
Risk Markers ◽  
Beta Thalassemia Major ◽  
Electrocardiographic Abnormalities

Serum Hepcidin as a Diagnostic Marker of Severe Iron Overload in Beta-thalassemia Major

2017 ◽  
Vol 84 (10) ◽  
pp. 745-750 ◽  
Author(s):  
Ahmed Maher Kaddah ◽  
Amina Abdel-Salam ◽  
Marwa Salah Farhan ◽  
Reham Ragab
Keyword(s):  
Iron Overload ◽  
Diagnostic Marker ◽  
Thalassemia Major ◽  
Beta Thalassemia ◽  
Beta Thalassemia Major ◽  
Serum Hepcidin

C0431: High Incidence of Thrombotic Cerebral Lesions in Adult Patients with Beta-Thalassemia Major

2014 ◽  
Vol 133 ◽  
pp. S116 ◽  
Author(s):  
I. Pazgal ◽  
E. Inbar ◽  
M. Cohen ◽  
O. Shpilberg ◽  
P. Raanani ◽  
...  
Keyword(s):  
Thalassemia Major ◽  
Adult Patients ◽  
Beta Thalassemia ◽  
Cerebral Lesions ◽  
Beta Thalassemia Major ◽  
High Incidence

scholarly journals Iron chelation therapy needed for serum ferritin overloaded patients of beta thalassemia major

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Wasim Muhammad ◽  
Muhammad Ishaq ◽  
Muhammad J. Khan ◽  
Umair Ahmad ◽  
Muhammad Waseem
Keyword(s):  
Serum Ferritin ◽  
Ferritin Level ◽  
Iron Chelation ◽  
Care Facility ◽  
Health Care Facility ◽  
Thalassemia Major ◽  
Beta Thalassemia ◽  
Cross Sectional ◽  
Beta Thalassemia Major ◽  
Khyber Pakhtunkhwa Province

The main objective of the current study is to evaluate the level and overload of serum ferritin in multi-transfused beta Thalassemia major patients. There is an earnest need to defend the chelation treatment and to make mindfulness about the results of serum ferritin in the patients beta Thalassemia major. This is a Cross sectional analytical study performed in Fatimid foundation Hayatabad, Peshawar, Khyber Pakhtunkhwa province of Pakistan. Those patients who has beta thalassemia major are included in this study. In this study there are total 108 patients in which 54 males and 54 females. The highest mean of serum ferritin level in the category of male was in the age of 12 years were finds 8160.5 ng/mL. Among the female the highest mean of ferritin level was in the age of 17 years were finds 13,349.5 ng/mL. In this study majority of patient’s revealed much high levels of serum ferritin. These levels reveal insufficient chelation. Appropriate chelation of iron load can improve the quality of the life of these patients. The low level of education, Poverty problems, and insufficient health care facility of are the main obstacle in the effective management of ferritin overload in thalassemia patients.

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