An Efficient Synthesis of 3,5-Dimethoxy-2,4-Difluorobenzoic Acid

2017 ◽  
Vol 41 (4) ◽  
pp. 239-240 ◽  
Author(s):  
Mingguang Zhang ◽  
Lin Qiu ◽  
Shuitao Yu ◽  
Zaixin Chen ◽  
Shifa Wang
Keyword(s):  
Efficient Synthesis ◽  
Target Compound ◽  
Reduction Of No ◽  
Tetrafluorobenzoic Acid ◽  
Moderate Yield

3,5-Dimethoxy-2,4-difluorobenzoic acid, as a key intermediate for preparing an impurity of moxifloxacin, was synthesised from 2,3,4,5-tetrafluorobenzoic acid in moderate yield by nitration, methoxyl substitution, reduction of NO2, diazotisation and reduction. The structures of the intermediates and the target compound were identified and determined with IR, NMR and HRMS (ESI).

A Practical Three-Step Synthesis of Vinylferrocene

Synthesis ◽  
2017 ◽  
Vol 50 (04) ◽  
pp. 760-763 ◽  
Author(s):  
Radovan Šebesta ◽  
Kristína Plevová ◽  
Brigita Mudráková
Keyword(s):  
Efficient Synthesis ◽  
Target Compound ◽  
One Pot

An improved, short and efficient synthesis of vinylferrocene is reported. This three-step synthesis includes Friedel–Crafts acylation, reduction, and a one-pot mesylation/elimination step to afford the target compound in 62% yield over three steps.

scholarly journals An Improved and Efficient Synthesis of Panobinostat

2018 ◽  
Vol 42 (9) ◽  
pp. 471-473
Author(s):  
Shanwen Chen ◽  
Peiming Zhang ◽  
Huali Chen ◽  
Pu Zhang ◽  
Yu Yu ◽  
...  
Keyword(s):  
Nucleophilic Substitution ◽  
Efficient Method ◽  
Industrial Production ◽  
Substitution Reaction ◽  
Efficient Synthesis ◽  
Target Compound ◽  
One Pot ◽  
H Nmr ◽  
C Nmr ◽  
Methyl Phenyl

An improved and efficient method for the synthesis of panobinostat was developed. The commercially available starting material 4-(chloromethyl)benzaldehyde was converted to ( E)-methyl 3-[4-(chloromethyl)phenyl]acrylate via the Wittig–Horner reaction and was then directly condensed with 2-(2-methyl-1 H-indol-3-yl)ethanamine to afford the key intermediate ( E)-methyl 3-[4-({[2-(2-methyl-1 H-indol-3-yl)ethyl]amino}methyl)phenyl]acrylate in a one-pot synthesis reactor. Subsequently a nucleophilic substitution reaction was carried out smoothly to generate the desired compound. The key intermediate and target compound were characterised by HRMS, 1H NMR and 13C NMR. This procedure is operationally simple and would be more suitable for industrial production.

A new facile and efficient synthesis of trans-(+)-sobrerol by biotransformation of α-pinene using extremophiles microorganisms

Planta Medica ◽  
2009 ◽  
Vol 75 (09) ◽  
Author(s):  
LA Vilaseca ◽  
J Quillaguamán ◽  
L Fuentes ◽  
O Sterner
Keyword(s):  
Efficient Synthesis

Effect of Fe on the Selective Catalytic Reduction of NO by NH3 at Low Temperature over Mn/CeO2-TiO2 Catalyst

2012 ◽  
Vol 27 (5) ◽  
pp. 495-500 ◽  
Author(s):  
Da-Wang WU ◽  
Qiu-Lin ZHANG ◽  
Tao LIN ◽  
Mao-Chu GONG ◽  
Yao-Qiang CHEN
Keyword(s):  
Low Temperature ◽  
Selective Catalytic Reduction ◽  
Catalytic Reduction ◽  
Reduction Of No

Highly efficient synthesis of methyl ethyl ketone oxime through ammoximation over Ti-MOR catalyst

2014 ◽  
Vol 34 (1) ◽  
pp. 243-250
Author(s):  
Jianghong DING ◽  
Le XU ◽  
Hao XU ◽  
Haihong WU ◽  
Yueming LIU ◽  
...  
Keyword(s):  
Methyl Ethyl Ketone ◽  
Methyl Ethyl ◽  
Efficient Synthesis ◽  
Highly Efficient
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