scholarly journals Effects of Cannabis in Parkinson’s Disease: A Systematic Review and Meta-Analysis

2021 ◽  
pp. 1-14
Author(s):  
Berzenn Urbi ◽  
Joel Corbett ◽  
Ian Hughes ◽  
Maame Amma Owusu ◽  
Sarah Thorning ◽  
...  
Keyword(s):  
Systematic Review ◽  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Meta Analysis ◽  
Relative Paucity ◽  
Randomized Studies ◽  
Treatment Benefits ◽  
Randomized Controlled Studies ◽  
Pain Improvement

The legalization of cannabis in many countries has allowed many Parkinson’s disease (PD) patients to turn to cannabis as a treatment. As such there is a growing interest from the PD community to be properly guided by evidence regarding potential treatment benefits of cannabis. This systematic review and meta-analysis aims to compile the best available evidence to help guide patients and their family, clinicians and researchers make informed decisions. A systematic search of the literature was conducted in June 2021. Five randomized controlled studies and eighteen non-randomized studies investigated cannabis treatment in PD patients. No compelling evidence was found to recommend the use of cannabis in PD patients. However, a potential benefit was identified with respect to alleviation of PD related tremor, anxiety, pain, improvement of sleep quality and quality of life. Given the relative paucity of well-designed randomized studies, there is an identified need for further investigation, particularly in these areas.

scholarly journals The Impact of Tai Chi on Motor Function, Balance, and Quality of Life in Parkinson’s Disease: A Systematic Review and Meta-Analysis

2021 ◽  
Vol 2021 ◽  
pp. 1-10
Author(s):  
Xing Yu ◽  
Xinze Wu ◽  
Guozhen Hou ◽  
Peipei Han ◽  
Liying Jiang ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Systematic Review ◽  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Motor Function ◽  
Methodological Quality ◽  
Tai Chi ◽  
Meta Analysis ◽  
Gait Velocity

Objective. Parkinson’s disease adversely affects function and quality of life, leading to increased mortality. The practice of Tai Chi has been associated with multifaceted improvements in health-related fitness. Considering the limited number of clinical studies included in previous reviews, inconsistent methodological quality, and inconclusive results, this meta-analysis aims to assess the effects of Tai Chi in patients with Parkinson’s disease. Method. Four English language databases and four Chinese databases were systematically searched for existing randomized controlled trials (RCTs) of Tai Chi in Parkinson’s disease from database inception through August 1, 2020. Methodological quality was appraised with the Cochrane Risk of Bias tool. A meta-analysis of comparative effects was performed using the Review Manager v.5.3 software. Results. Seventeen published RCTs totaling 951 subjects were included. Results showed that Tai Chi has a statistically significant effect on the outcomes of gait velocity, unified Parkinson’s disease rating scale (UPDRS) motor score, activities-specific balance confidence (ABC) score, and Berg Balance Scale (BBS). The effects on the Timed Up and Go Test (TUGT) and Parkinson’s Disease Questionnaire-39 (PDQ-39) were not statistically significant. Conclusions. This systematic review and meta-analysis of Parkinson’s disease and Tai Chi suggests Tai Chi is a relatively safe activity that can result in gains in general motor function and improve bradykinesia and balance. It has no statistically significant advantage for quality of life and functional mobility. Further randomized trials with larger sample sizes and of higher methodological quality are needed to confirm these results and to assess the feasibility of Tai Chi intervention for potential different clinical applications.

Effects of dance practice on functional mobility, motor symptoms and quality of life in people with Parkinson’s disease: a systematic review with meta-analysis

2017 ◽  
Vol 30 (7) ◽  
pp. 727-735 ◽  
Author(s):  
Marcela dos Santos Delabary ◽  
Isabel Giovannini Komeroski ◽  
Elren Passos Monteiro ◽  
Rochelle Rocha Costa ◽  
Aline Nogueira Haas
Keyword(s):  
Quality Of Life ◽  
Systematic Review ◽  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Meta Analysis ◽  
Functional Mobility ◽  
Motor Symptoms

scholarly journals Evidence of disease severity, cognitive and physical outcomes of dance interventions for persons with Parkinson’s Disease: a systematic review and meta-analysis

2021 ◽  
Vol 21 (1) ◽  
Author(s):  
Sophia Rasheeqa Ismail ◽  
Shaun Wen Huey Lee ◽  
Dafna Merom ◽  
Puteri Sofia Nadira Megat Kamaruddin ◽  
Min San Chong ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Systematic Review ◽  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Adverse Events ◽  
Disease Severity ◽  
Meta Analysis ◽  
Small Samples ◽  
Physical Outcomes

Abstract Background Patients with Parkinson’s Disease (PD) usually experience worsening of both motor and non-motor symptoms. Dancing has been postulated to help patients with Parkinson’s via several mechanisms that lead to improved physical, cognitive and social functions. Methods This systematic review was conducted following Cochrane methodology and reported following the PRISMA guideline. Four databases (up to June 2021) were searched for RCTs comparing dance to standard or other physical therapy for improvements in disease severity, quality of life, cognitive and physical outcomes as well as adverse events in patients with PD. We synthesised data using RevMan and included certainty-of-evidence rating (GRADE) for major outcomes. Results A total of 20 RCTs (N = 723) articles that evaluated Tango, Ballroom, Irish, Waltz-Foxtrot, Folk, Turo, mixed dances and a PD-tailored dance were included. Dancers (versus non-dancers) had better motor experience (MDS-UPDRS 3) (MD -6.01, 95 % CI -9.97 to -3.84; n = 148; 5 RCTs) and improved balance (MiniBest Test) (MD 4.47, 95 % CI 2.29 to 6.66; n = 95; 3 RCTs), with no consistent differences on gait, agility and cognitive outcomes. Small samples and methodological limitations resulted in low-certainty-evidence across outcomes. Conclusions Apart from a suggestion that dance intervention modestly reduced motor disease severity and improved certain aspects of balance, there is insufficient evidence on all other outcomes, such as agility and motor function, cognitive, mood and social outcomes, quality of life as well as adverse events including the risk of fall. As evidence is insufficient to inform practice, evidence of benefits on motor disease severity and balance needs to be considered in the context of user-perception of benefit versus harm and acceptability in the development of practice guideline recommendations.

DTI for Parkinson's Disease: A Protocol for Systematic Review and Meta-Analysis

2020 ◽  
Author(s):  
Xiaoqin Yin ◽  
Meijun Liu ◽  
Yang Liao ◽  
Shuoguo Jin ◽  
Qizheng Li ◽  
...  
Keyword(s):  
Systematic Review ◽  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Meta Analysis ◽  
Biological Marker ◽  
Diagnostic Value ◽  
English Studies ◽  
Data Synthesis ◽  
Parameter Values

Abstract Background: There is no robust biological marker for the diagnosis of Parkinson's disease, and most of them are diagnosed until motor symptoms develop, which may affect the early intervention and prognosis Objective: To evaluate the diagnostic value of different parameter values of DTI in PD.Methods and analysis: We will systematically search the cochrane, pubmed, and embase databases, but we only consider observational studies and English studies. The main outcomes are DTI parameters, including FA, MDC, and ADC. We will evaluate the quality of the included studies through the NOS scale, and the data synthesis will be analyzed by revman5.3.Discussion: This systematic review will integrate all relevant DTI observation results on PD imaging, and evaluate whether DTI can be used as a biological marker for the diagnosis of PD. The review results will provide a useful reference for the diagnosis of PDSystematic review registration: The protocol has been registered at the International Platform of Registered Systematic Review and Meta-analysis Protocols(INPLASY202070098).

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