Pretreatment of nerve grafts with resveratrol improves axonal regeneration following replantation surgery for nerve root avulsion injury in rats

2018 ◽  
Vol 36 (5) ◽  
pp. 647-658 ◽  
Author(s):  
Hiroki Oda ◽  
Souichi Ohta ◽  
Ryosuke Ikeguchi ◽  
Takashi Noguchi ◽  
Yukitoshi Kaizawa ◽  
...  
Keyword(s):  
Nerve Root ◽  
Axonal Regeneration ◽  
Root Avulsion ◽  
Avulsion Injury ◽  
Nerve Grafts ◽  
Nerve Root Avulsion

scholarly journals PLGA-PEG-PLGA hydrogel with NEP1-40 promotes the functional recovery of brachial plexus root avulsion in adult rats

PeerJ ◽  
2021 ◽  
Vol 9 ◽  
pp. e12269
Author(s):  
Wenlai Guo ◽  
Bingbing Pei ◽  
Zehui Li ◽  
Xiao Lan Ou ◽  
Tianwen Sun ◽  
...  
Keyword(s):  
Brachial Plexus ◽  
Functional Recovery ◽  
Rat Model ◽  
Nerve Root ◽  
Axonal Regeneration ◽  
Biceps Brachii ◽  
Nerve Tissue ◽  
Root Avulsion ◽  
Avulsion Injury ◽  
Nerve Root Avulsion

Adult brachial plexus root avulsion can cause serious damage to nerve tissue and impair axonal regeneration, making the recovery of nerve function difficult. Nogo-A extracellular peptide residues 1-40 (NEP1-40) promote axonal regeneration by inhibiting the Nogo-66 receptor (NgR1), and poly (D, L-lactide-co-glycolide)-poly (ethylene glycol)-poly (D, L-lactide-co-glycolide) (PLGA-PEG-PLGA) hydrogel can be used to fill in tissue defects and concurrently function to sustain the release of NEP1-40. In this study, we established an adult rat model of brachial plexus nerve root avulsion injury and conducted nerve root replantation. PLGA-PEG-PLGA hydrogel combined with NEP1-40 was used to promote nerve regeneration and functional recovery in this rat model. Our results demonstrated that functional recovery was enhanced, and the survival rate of spinal anterior horn motoneurons was higher in rats that received a combination of PLGA-PEG-PLGA hydrogel and NEP1-40 than in those receiving other treatments. The combined therapy also significantly increased the number of fluorescent retrogradely labeled neurons, muscle fiber diameter, and motor endplate area of the biceps brachii. In conclusion, this study demonstrates that the effects of PLGA-PEG-PLGA hydrogel combined with NEP1-40 are superior to those of other therapies used to treat brachial plexus nerve root avulsion injury. Therefore, future studies should investigate the potential of PLGA-PEG-PLGA hydrogel as a primary treatment for brachial plexus root avulsion.

scholarly journals The neuroprotective effect of erythropoietin on spinal motor neurons after nerve root avulsion injury in rats

2015 ◽  
Vol 33 (4) ◽  
pp. 461-470 ◽  
Author(s):  
Takashi Noguchi ◽  
Souichi Ohta ◽  
Ryosuke Kakinoki ◽  
Ryosuke Ikeguchi ◽  
Yukitoshi Kaizawa ◽  
...  
Keyword(s):  
Motor Neurons ◽  
Nerve Root ◽  
Neuroprotective Effect ◽  
Root Avulsion ◽  
Avulsion Injury ◽  
Spinal Motor Neurons ◽  
Spinal Motor ◽  
Nerve Root Avulsion

Magnetic resonance evaluation of cervical nerve root avulsion injury

1996 ◽  
Vol 3 (4) ◽  
pp. 172-175
Author(s):  
Ziad L. Deeb ◽  
Kevin J. Kelly ◽  
Richard H. Daffner
Keyword(s):  
Magnetic Resonance ◽  
Nerve Root ◽  
Root Avulsion ◽  
Cervical Nerve Root ◽  
Cervical Nerve ◽  
Avulsion Injury ◽  
Nerve Root Avulsion

scholarly journals Upper thoracic spinal cord herniation after traumatic nerve root avulsion

2004 ◽  
Vol 16 (5) ◽  
pp. 306-309
Author(s):  
Victor R. DaSilva ◽  
Mubarak Al-Gahtany ◽  
Rajiv Midha ◽  
Dipanka Sarma ◽  
Perry Cooper
Keyword(s):  
Spinal Cord ◽  
Nerve Root ◽  
Signs And Symptoms ◽  
Root Avulsion ◽  
Thoracic Spinal Cord ◽  
First Case ◽  
Thoracic Spinal ◽  
Spinal Cord Herniation ◽  
Nerve Root Avulsion ◽  
Upper Thoracic

✓ Transdural herniation of the spinal cord, a rare but well-documented entity, has been reported sporadically for more than 25 years as a possible cause for various neurological signs and symptoms ranging from isolated sensory or motor findings to myelopathy and Brown–Séquard syndrome. The authors report, to the best of their knowledge, the first case of upper thoracic spinal cord herniation occurring after traumatic nerve root avulsion.

scholarly journals A new cervical nerve root avulsion model using a posterior extra-vertebral approach in rats

2014 ◽  
Vol 08 (01) ◽  
pp. e19-e27 ◽  
Author(s):  
Takashi Noguchi ◽  
Souichi Ohta ◽  
Ryosuke Kakinoki ◽  
Yukitoshi Kaizawa ◽  
Shuichi Matsuda
Keyword(s):  
Nerve Root ◽  
Root Avulsion ◽  
Cervical Nerve Root ◽  
Cervical Nerve ◽  
Nerve Root Avulsion
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