scholarly journals Kunitz-Type Protease Inhibitor 1

2020 ◽  
Author(s):  
Keyword(s):  
Protease Inhibitor ◽  
Kunitz Type ◽  
Kunitz Type Protease Inhibitor

scholarly journals Kunitz-type protease inhibitor as a vaccine candidate against schistosomiasis mansoni

2018 ◽  
Vol 66 ◽  
pp. 26-32 ◽  
Author(s):  
Shiwanthi L. Ranasinghe ◽  
Mary Duke ◽  
Marina Harvie ◽  
Donald P. McManus
Keyword(s):  
Protease Inhibitor ◽  
Vaccine Candidate ◽  
Schistosomiasis Mansoni ◽  
Kunitz Type ◽  
Kunitz Type Protease Inhibitor

scholarly journals Enhanced Plasmin Inhibition by a Reactive Center Lysine Mutant of the Kunitz-type Protease Inhibitor Domain of the Amyloid β-Protein Precursor

1995 ◽  
Vol 270 (39) ◽  
pp. 22827-22830 ◽  
Author(s):  
William E. Van Nostrand ◽  
Alvin H. Schmaier ◽  
Robert S. Siegel ◽  
Steven L. Wagner ◽  
William C. Raschke
Keyword(s):  
Protease Inhibitor ◽  
Amyloid Β ◽  
Amyloid Β Protein ◽  
Protein Precursor ◽  
Β Protein ◽  
Reactive Center ◽  
Kunitz Type ◽  
Kunitz Type Protease Inhibitor

Cloning of a new Kunitz-type protease inhibitor with a putative transmembrane domain overexpressed in pancreatic cancer

1998 ◽  
Vol 1395 (1) ◽  
pp. 88-95 ◽  
Author(s):  
Friederike Müller-Pillasch ◽  
Christine Wallrapp ◽  
Katrin Bartels ◽  
Gabor Varga ◽  
Helmut Friess ◽  
...  
Keyword(s):  
Pancreatic Cancer ◽  
Protease Inhibitor ◽  
Transmembrane Domain ◽  
Putative Transmembrane Domain ◽  
Kunitz Type ◽  
Kunitz Type Protease Inhibitor

A kunitz-type protease inhibitor bikunin disrupts ligand-induced oligomerization of receptors for transforming growth factor (TGF)-β and subsequently suppresses TGF-β signalings

FEBS Letters ◽  
2004 ◽  
Vol 576 (3) ◽  
pp. 408-416 ◽  
Author(s):  
Tatsuo Yagyu ◽  
Hiroshi Kobayashi ◽  
Kiyoshi Wakahara ◽  
Hidenori Matsuzaki ◽  
Toshiharu Kondo ◽  
...  
Keyword(s):  
Growth Factor ◽  
Protease Inhibitor ◽  
Transforming Growth Factor ◽  
Kunitz Type ◽  
Kunitz Type Protease Inhibitor

scholarly journals Kunitz type protease inhibitor EgKI-1 from the canine tapeworm Echinococcus granulosus as a promising anti-cancer therapeutic

2018 ◽  
Author(s):  
Shiwanthi L Ranasinghe ◽  
Glen M Boyle ◽  
Katja Fischer ◽  
Jeremy Potriquet ◽  
Jason P Mulvenna ◽  
...  
Keyword(s):  
Cell Growth ◽  
Protease Inhibitor ◽  
Hydatid Cyst ◽  
Echinococcus Granulosus ◽  
Cancer Cell ◽  
Dependent Manner ◽  
Anti Cancer ◽  
Kunitz Type ◽  
Kunitz Type Protease Inhibitor

AbstractEgKI-1, a member of the Kunitz type protease inhibitor family, is highly expressed by the oncosphere of the canine tapeworm Echinococcus granulosus, the stage that is infectious to humans and ungulates, giving rise to a hydatid cyst localized to the liver and other organs. Larval protoscoleces, which develop within the hydatid cyst, have been shown to possess anti-cancer properties, although the precise molecules involved have not been identified. We show that recombinant EgKI-1 inhibits the growth and migration of a range of human cancers including breast, melanoma and cervical cancer cell lines in a dose-dependent manner in vitro without affecting normal cell growth. Furthermore, EgKI-1 treatment arrested the cancer cell growth by disrupting the cell cycle and induced apoptosis of cancer cells in vitro. An in vivo model of triple negative breast cancer (MDA-MB-231) in BALB/c nude mice showed significant tumor growth reduction in EgKI-1-treated mice compared with controls. These findings indicate that EgKI-1 shows promise for future development as an anti-cancer therapeutic.

Characterization of Kunitz-type protease inhibitor purified from hemolymph of Galleria mellonella larvae

2010 ◽  
Vol 40 (12) ◽  
pp. 873-882 ◽  
Author(s):  
Joon Ha Lee ◽  
Chong Han Kim ◽  
Yong Pyo Shin ◽  
Ho Jin Park ◽  
Seungmi Park ◽  
...  
Keyword(s):  
Protease Inhibitor ◽  
Galleria Mellonella ◽  
Kunitz Type ◽  
Kunitz Type Protease Inhibitor

A Kunitz type protease inhibitor related protein is synthesized in Drosophila prepupal salivary glands and released into the moulting fluid during pupation

2004 ◽  
Vol 34 (8) ◽  
pp. 855-869 ◽  
Author(s):  
Horst Kress ◽  
Andres Jarrin ◽  
Eduardo Thüroff ◽  
Robert Saunders ◽  
Chris Weise ◽  
...  
Keyword(s):  
Protease Inhibitor ◽  
Salivary Glands ◽  
Related Protein ◽  
Kunitz Type ◽  
Kunitz Type Protease Inhibitor

Macromolecular properties and partial amino acid sequence of a Kunitz-type protease inhibitor from okra (Abelmoschus esculentus) seeds

2019 ◽  
Vol 44 (2) ◽  
Author(s):  
Debparna Datta ◽  
Gottfried Pohlentz ◽  
Saradamoni Mondal ◽  
M Bala Divya ◽  
Lalitha Guruprasad ◽  
...  
Keyword(s):  
Amino Acid ◽  
Amino Acid Sequence ◽  
Protease Inhibitor ◽  
Abelmoschus Esculentus ◽  
Partial Amino Acid Sequence ◽  
Kunitz Type ◽  
Kunitz Type Protease Inhibitor
Sign in / Sign up

Export Citation Format

Share Document