Cervical Gland | ScienceGate

Carnosine has been demonstrated to play an antitumorigenic role in certain types of cancer. However, its underlying mechanism is unclear. In this study, the roles of carnosine in cell proliferation and its underlying mechanism were investigated in the cultured human cervical gland carcinoma cells HeLa and cervical squamous carcinoma cells SiHa. The results showed that carnosine exerted a significant inhibitory effect on the proliferation of HeLa cells, whereas its inhibitory action on the proliferation of SiHa cells was much weaker. Carnosine decreased the ATP content through inhibiting both mitochondrial respiration and glycolysis pathways in cultured HeLa cells but not SiHa cells. Carnosine reduced the activities of isocitrate dehydrogenase and malate dehydrogenase in TCA (tricarboxylic acid) cycle and the activities of mitochondrial electron transport chain complex I, II, III, and IV in HeLa cells but not SiHa cells. Carnosine also decreased the mRNA and protein expression levels of ClpP, which plays a key role in maintaining the mitochondrial function in HeLa cells. In addition, carnosine induced G1 arrest by inhibiting the G1-S phase transition in both HeLa and SiHa cells. Taken together, these findings suggest that carnosine has a strong inhibitory action on the proliferation of human cervical gland carcinoma cells rather than cervical squamous carcinoma cells. Mitochondrial bioenergetics and glycolysis pathways and cell cycle may be involved in the carnosine action on the cell proliferation in cultured human cervical gland carcinoma cells HeLa.

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The proportional frequency of the human and bovine types of tubercle bacilli in human pulmonary tuberculosis in the middle and south of Scotland

Journal of Hygiene ◽

10.1017/s0022172400027844 ◽

1940 ◽

Vol 40 (3) ◽

pp. 365-376 ◽

Cited By ~ 6

Author(s):

A. Stanley Griffith

Keyword(s):

Pulmonary Tuberculosis ◽

Thoracic Spine ◽

Guinea Pigs ◽

Direct Contact ◽

Spinal Tuberculosis ◽

Raw Milk ◽

Tubercle Bacillus ◽

Post Mortem ◽

Cervical Gland ◽

Gland Enlargement

1. The types of tubercle bacilli have been determined in the sputum of 515 cases of pulmonary tuberculosis occurring in the middle and south of Scotland.2. Of the 515 cases 484 were human (476 eugonic and eight dysgonic) and thirty-one were bovine infections.3. With the exception of the strains from one case (case 28) all the bovine strains, seventy in number, were typical culturally and fully virulent for rabbits.4. The attenuated strains, two in number, from case 28 were slightly less virulent than typical bovine strains for rabbits and (one strain) for guinea-pigs.5. The percentage of bovine infections found in this series, including the Cumberland case, during the years 1931–9 was 6·0, but excluding that case it was 5·8.6. The percentage of bovine infections found by Munro during about the same period and covering the same regions was 5·0%.7. In Munro's series strains of bovine tubercle bacilli were obtained from fifty-eight out of 1165 persons (5·0%). Five of his cases yielded attenuated bovine strains and in one of these the pulmonary tuberculosis was preceded by tuberculosis of the thoracic spine.8. In my series the attenuated tubercle bacilli came from a case (case 28) of pulmonary tuberculosis which was preceded nearly 20 years previously by tuberculosis of the lower dorsal spine.Dr Munro and others have made post-mortem examinations on cases of phthisis pulmonalis due to bovine bacilli, but I wish to defer reference to these until we can review them altogether.In this series there are seven instances of cervical gland enlargement and one instance (case 28) of spinal tuberculosis occurring previous to the development of phthisis pulmonalis. These, I think, are examples of alimentary infection with the bovine tubercle bacillus. Thus, with the three autopsies previously mentioned, there are eleven cases, or about one-third, which are almost certainly alimentary in origin. As for the rest of the cases, 20 in number, no glandular enlargements in neck or abdomen were detected but the majority, if not all, were probably alimentary in origin, since all the persons drank a lot of raw milk and only five came into direct contact with cattle in their employment.

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Association of Progesterone, Pessary, and Antibiotic for Treating Pregnant Woman with Short Cervix Syndrome: Importance of Magnetic Resonance Imaging in the Assessment of Pessary Position

Journal of Clinical Imaging Science ◽

10.4103/2156-7514.114802 ◽

2013 ◽

Vol 3 ◽

pp. 27 ◽

Cited By ~ 1

Author(s):

Edward Araujo Júnior ◽

Eduardo Félix Martins Santana ◽

Luciano Marcondes Machado Nardozza ◽

Antonio Fernandes Moron

Keyword(s):

Magnetic Resonance Imaging ◽

Case Report ◽

Pregnant Woman ◽

Magnetic Resonance ◽

Antibiotic Therapy ◽

Triple Therapy ◽

Resonance Imaging ◽

Trendelenburg Position ◽

Short Cervix ◽

Cervical Gland

Preterm delivery (PD) is the most important cause of neonatal mortality, particularly before the 32nd week of pregnancy. A short cervix is the most important quantitative marker for predicting PD. However, there are other qualitative markers such as cervical gland area, cervical funneling, and sludge. We present the case of a pregnant woman who was diagnosed with a short cervix at 14-weeks and demonstrate the use of triple therapy, which helped to achieve a good perinatal result. A 37-year-old pregnant woman (G3P0) was referred to our service at 14-weeks of pregnancy presenting with a short cervix (20 mm) and a positive sludge sign. She was hospitalized; a pessary was inserted, and started on antibiotic therapy (clindamycin and cefalotin for 10 days). At 20 weeks, she was again admitted to the hospital, and this time presented with a further shortened cervix (9 mm), cervical funneling, and a positive sludge sign, with the pessary in position. The following procedures were performed: Amniocentesis on the sludge (negative bacterioscopy), another cycle of antibiotics, administration of oral progesterone, and imaging to determine retention of pessary position. The patient was placed in the Trendelenburg position and remained hospitalized for 82 days. At 32 + 1 weeks, the fetus presented distress (tachycardia). C-section was performed, producing a live female newborn weighing 2,180 g and presenting Apgar indexes of 8/8. This case report demonstrates the importance of magnetic resonance imaging to assess the position of pessary in a pregnant woman with short cervix.

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