scholarly journals Complement Deficiency

2020 ◽  
Author(s):  
Keyword(s):  
Complement Deficiency

Complement deficiency ameliorates smoke-induced nasal damage

2009 ◽  
Vol 141 (3) ◽  
pp. P110-P110
Author(s):  
Kara Davis ◽  
Rodney Schlosser ◽  
Carl Atkinson
Keyword(s):  
Complement Deficiency

Early manifestation and recognition of C2 complement deficiency in the form of pyogenic infection in infancy

2003 ◽  
Vol 39 (4) ◽  
pp. 274-277 ◽  
Author(s):  
J Litzman ◽  
T Freiberger ◽  
D Bartonkova ◽  
M Vlkova ◽  
V Thon ◽  
...  
Keyword(s):  
Complement Deficiency ◽  
Pyogenic Infection ◽  
Early Manifestation

scholarly journals DEFICIENCY OF THE SIXTH COMPONENT OF COMPLEMENT IN RABBITS WITH AN INHERITED COMPLEMENT DEFECT

1966 ◽  
Vol 124 (4) ◽  
pp. 773-785 ◽  
Author(s):  
Klaus Rother ◽  
Ursula Rother ◽  
Hans J. Müller-Eberhard ◽  
Ulf R. Nilsson
Keyword(s):  
Complement System ◽  
Hemolytic Activity ◽  
Complement Deficiency ◽  
Rabbit Serum ◽  
Partial Purification ◽  
Normal Rabbit Serum ◽  
Chemically Modified ◽  
System A ◽  
Inactive Form

A strain of rabbits with an inherited complement deficiency was shown to lack the sixth component of the hemolytic complement system. A method was elaborated for the partial purification of this component from normal rabbit serum. Upon injection of partially purified rabbit C'6 into C'6-deficient animals, an antibody was obtained which specifically inhibited the hemolytic activity of C'6. The data suggest that C'6-deficient serum either lacks the C'6 molecule or contains it in a chemically modified and inactive form.

Human complement deficiency states and infection

1993 ◽  
pp. 173-197 ◽  
Author(s):  
P. Densen
Keyword(s):  
Complement Deficiency ◽  
Human Complement

Complement: Deficiency Diseases

2015 ◽  
pp. 1-9 ◽  
Author(s):  
Lillemor Skattum ◽  
Lennart Truedsson
Keyword(s):  
Complement Deficiency ◽  
Deficiency Diseases

scholarly journals Complement deficiency in pediatric-onset systemic lupus erythematosus

2018 ◽  
Vol 10 (02) ◽  
pp. 232-236 ◽  
Author(s):  
Parisa Afzali ◽  
Anna Isaeian ◽  
Peyman Sadeghi ◽  
Bobak Moazzami ◽  
Nima Parvaneh ◽  
...  
Keyword(s):  
Systemic Lupus Erythematosus ◽  
Lupus Erythematosus ◽  
Musculoskeletal Symptoms ◽  
Complement C3 ◽  
Complement Deficiency ◽  
Control Group ◽  
Systemic Lupus ◽  
Cutaneous Manifestations ◽  
Pediatric Onset ◽  
Onset Systemic Lupus Erythematosus

Abstract BACKGROUND: Pediatric-onset systemic lupus erythematosus (pSLE) accounts for about 10%-20% of all patients with SLE. Deficiencies in early complement components of the classical pathway are the strong genetic risk factor for the development of SLE. In this study, clinical and laboratory manifestations of both complement-deficient and normal complement pSLE patients were compared. MATERIALS AND METHODS: To investigate clinical and immunological manifestations of pSLE in Iran, 36 consecutive pSLE patients (onset before 18 years) who were followed up over a period of 2 years, were studied. Complement C1q and C2 levels were measured using radial immunodifusion assay and complement C3 and C4 levels were measured using nephelometry. Medical records were retrospectively evaluated from patient database of Children Medical Center Hospital. Data were assessed through descriptive analysis (confidence interval = 95%), paired t-test, and Pearson correlation test. RESULTS: Twenty-one patients (58%) had at least one component of complement deficiency. Ten patients (27%) had low C1q level, 11 patients (30.5%) had low C2, nine patients (25%) had low C3, and four patients (11%) had low C4 level. Serum level of complement in pSLE was significantly lower than the control group, except C4 (P = 0.005). The low C1q patients had an earlier age of onset of disease (P < 0.0001). The cutaneous manifestations were more frequent and much more severe in pSLE with low complement (100% vs. 73%). The frequency of renal and musculoskeletal symptoms was equal, but renal morbidity was more common in pSLE with low complement. Positivity for anti-ds-DNA was less common in pSLE with low complement (71% vs. 86%). CONCLUSION: In pSLE patients with early disease onset and more aggressive SLE manifestations and negative anti-ds-DNA test, complement deficiency should be considered.

scholarly journals Meningococcaemia causing necrotizing cellulitis associated with acquired complement deficiency after gastric bypass surgery: a case report

2020 ◽  
Vol 20 (1) ◽  
Author(s):  
Zoe Pletschette ◽  
Elodie De Groote ◽  
Wesley Mattheus ◽  
Charlotte Waxweiler ◽  
Jacques Creteur ◽  
...  
Keyword(s):  
Gastric Bypass ◽  
Case Report ◽  
Bypass Surgery ◽  
Gastric Bypass Surgery ◽  
Complement Deficiency
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