COVID-19 in Joint Ageing and Osteoarthritis: Current Status and Perspectives

COVID-19 is a trending topic worldwide due to its immense impact on society. Recent trends have shifted from acute effects towards the long-term morbidity of COVID-19. In this review, we hypothesize that SARS-CoV-2 contributes to age-related perturbations in endothelial and adipose tissue, which are known to characterize the early aging process. This would explain the long-lasting symptoms of SARS-CoV-2 as the result of an accelerated aging process. Connective tissues such as adipose tissue and musculoskeletal tissue are the primary sites of aging. Therefore, current literature was analyzed focusing on the musculoskeletal symptoms in COVID-19 patients. Hypovitaminosis D, increased fragility, and calcium deficiency point towards bone aging, while joint and muscle pain are typical for joint and muscle aging, respectively. These characteristics could be classified as early osteoarthritis-like phenotype. Exploration of the impact of SARS-CoV-2 and osteoarthritis on endothelial and adipose tissue, as well as neuronal function, showed similar perturbations. At a molecular level, this could be attributed to the angiotensin-converting enzyme 2 expression, renin-angiotensin system dysfunction, and inflammation. Finally, the influence of the nicotinic cholinergic system is being evaluated as a new treatment strategy. This is combined with the current knowledge of musculoskeletal aging to pave the road towards the treatment of long-term COVID-19.

Prevalence of Self-Reported Work-related Musculoskeletal Symptoms among Software Employees in Hyderabad, India

Background: This study has been carried out to analyze the prevalence of self-reported work-related musculoskeletal symptoms among software professionals and to utilize the findings to design an effective preventive interventional program for WRMSDs. Subjects & Methods: This cross-sectional descriptive data analysis was done among 665 software employees both male and female from various companies in Q city Tech Park, Hyderabad. Data collected with “Cornell Musculoskeletal Discomfort Questionnaire” (CMDQ). Results: A total of 640 subjects were eligible for this study. Prevalence of WRMSDs to be 67%. The most common sites of reported symptoms are neck (65.0%), upper back (56.4%), lower back (62.6%), right shoulder (41.4%), left shoulder (35.4%) and right thigh (41.4%). Women were more likely to report symptoms in neck, lower back and both shoulder region than men (p<0.05). Discomforts in neck, lower back and right shoulder are greatly shown impact on work performance. Conclusion: WRMSDs are highly prevalent is software professionals and women at more risk than men. These findings indicate the need for more attention to WRMSDs and design of effective preventive strategies. Keywords: musculoskeletal pain, Prevalence, software professionals, work related musculoskeletal disorders.

Correlations between body postures and musculoskeletal pain in guitar players

Background The guitar-playing community is the largest group at risk of developing playing related musculoskeletal disorders. A thorough investigation of the relationships between the various risk factors and players’ report on musculoskeletal pain using objective and accurate means of assessment has yet to be reported. Purpose (a) to explore the correlations between demographic characteristics, anthropometric measurements, playing habits, and personal habits of guitar player and their complaints of musculoskeletal pain, (b) explore the correlations between the upper body kinematics of guitar players during playing the guitar and their complaints of musculoskeletal pain, and (c) compare the upper body kinematics of guitar players during playing the guitar while sitting versus standing. Methods Twenty-five guitar players (27.5±4.6 years old) filled out questionnaires regarding their guitar-playing habits, and the Standardized Nordic Questionnaires for the analysis of musculoskeletal symptoms. Kinematics of their torso and upper limbs were tracked while they played a tune twice, once while sitting and once while standing. Results We found moderate correlations between the number of painful joints in the last year and factors, such as physical comfort while playing, years of playing, and position during playing. During standing, lower back pain severity correlated with the rotation range of the torso, while during sitting, it moderately correlated with the average radial-ulnar deviation of the right wrist. During sitting, we found higher anterior and right tilt of the torso, combined with greater abduction of the right shoulder, higher flexion in the left shoulder and higher radial deviation in the left wrist. Conclusion Our results point to several risk factors, related both to playing habits but also to playing posture, which should be considered by the guitar players in order to prevent playing-related musculoskeletal disorders.

Investigation of Screen Time Inclination and the Accompanying Visual and Musculoskeletal Discomfort in Young Smartphone Users

The purpose of this study is to investigate the screen time inclination and its accompanying visual and musculoskeletal discomfort in young smartphone users. Thirty-one smartphone users aged between 20 - 30 years old were recruited through convenient sampling. The screen time patterns were recorded daily for a week and documented using Action Dash on Google Play Store according to the times of the day (morning, afternoon evening and night). Accompanying visual and musculoskeletal symptoms were examined through a self-reporting questionnaire survey. The questions used in the questionnaire were adapted and modified from the Asthenopia Questionnaire and Nordic Musculoskeletal Questionnaire. Results showed that young smartphone users spent approximately 30 % of their time on screen and were relatively similar for different times of the day. Daily screen time was approximately 7.36 ± 1.74 h. Most users engaged in WhatsApp (74 %), followed by YouTube (68 %), Instagram (65 %) and Twitter (39 %). Tired eyes were reported by all smartphone users. A positive correlation was only found between weekly screen time and eye strain (p < 0.05). All musculoskeletal symptoms were self-reported by young smartphone users in our study but anatomical locations varied in percentages. Neck pain was the most significant musculoskeletal symptom associated with screen time (OR = 4.80, 95 % CI: 0.95 - 24.14, p < 0.05). Every smartphone user reported at least 1 type of visual symptom. All smartphone users reported tired eyes. In conclusion, our results showed that smartphone users spent one third of their time daily on-screen and mostly on social media. Tired eyes and neck pain were the most common accompanying symptoms. Visuo-skeletal symptoms are common among young and healthy smartphone users. Our findings advocate that future strategic plans to address digital related health problems from the perspective of health education, promotion and protection should be inclusive of youth. HIGHLIGHTS Excessive screen time is a public health concern Adverse health implications have been linked to excessive electronic usage Smartphone users spend one-third of their time daily on-screen and mostly on social media Visuo-skeletal symptoms are common among young and healthy smartphone users Tired eyes and neck pain are the most common accompanying symptoms GRAPHICAL ABSTRACT

Biological and clinical correlates of the patient health questionnaire-9: exploratory cross-sectional analyses of the baseline health study

ObjectivesWe assessed the relationship between the Patient Health Questionnaire-9 (PHQ-9) at intake and other measurements intended to assess biological factors, markers of disease and health status.Design, setting and participantsWe performed a cross-sectional analysis of 2365 participants from the Baseline Health Study, a prospective cohort of adults selected to represent major demographic groups in the USA. Participants underwent deep phenotyping on demographic, clinical, laboratory, functional and imaging findings.ImportanceDespite extensive research on the clinical implications of the PHQ-9, data are limited on the relationship between PHQ-9 scores and other measures of health and disease; we sought to better understand this relationship.InterventionsNone.Main outcomes and measuresCross-sectional measures of medical illnesses, gait, balance strength, activities of daily living, imaging and laboratory tests.ResultsCompared with lower PHQ-9 scores, higher scores were associated with female sex (46.9%–66.7%), younger participants (53.6–42.4 years) and compromised physical status (higher resting heart rates (65 vs 75 bpm), larger body mass index (26.5–30 kg/m2), greater waist circumference (91–96.5 cm)) and chronic conditions, including gastro-oesophageal reflux disease (13.2%–24.7%) and asthma (9.5%–20.4%) (p<0.0001). Increasing PHQ-9 score was associated with a higher frequency of comorbidities (migraines (6%–20.4%)) and active symptoms (leg cramps (6.4%–24.7%), mood change (1.2%–47.3%), lack of energy (1.2%–57%)) (p<0.0001). After adjustment for relevant demographic, socioeconomic, behavioural and medical characteristics, we found that memory change, tension, shortness of breath and indicators of musculoskeletal symptoms (backache and neck pain) are related to higher PHQ-9 scores (p<0.0001).ConclusionsOur study highlights how: (1) even subthreshold depressive symptoms (measured by PHQ-9) may be indicative of several individual- and population-level concerns that demand more attention; and (2) depression should be considered a comorbidity in common disease.Trial registration numberNCT03154346.

Acute giardiasis and Chapman reflexes: Musculoskeletal symptoms preceding, during and after infection

Giardiasis is an acute infection caused by Giardia lamblia, which produces profuse secretory diarrhea that can lead to dehydration and electrolyte derangement. Musculoskeletal manifestations resulting because of giardiasis occur due to prolonged inflammation and viscero-somatic reflexes of the pathophysiology for this disease process. By treating the parasitic infection with an antiparasitic agent, as well as treating the somatic dysfunctions with osteopathic manipulative treatment, analgesics and a home exercise program, the patient in the following article experienced an uneventful course of treatment and a complete recovery including resolution of the pain.

Musculoskeletal symptoms in formal and informal caregivers of elderly people

ABSTRACT Objective: to evaluate musculoskeletal symptoms in formal and informal caregivers of elderly people, and check association with personal and work-related factors. Methods: this is a cross-sectional study. Instruments for assessment were the International Physical Activity Questionnaire, Self-Reporting Questionnaire-20, Borg’s effort perception scale and Nordic Musculoskeletal Questionnaire. Results: informal caregivers had been working for a longer time (60.2% vs. 41%), had more hours of work (37.4% >12h for day), less time off (85.4% vs. 2.5%) and lack of care guidelines (90.2%). The region with the most musculoskeletal symptoms was the spine and the greater dependence of the elderly, the greater the chances of developing musculoskeletal symptoms (OR= 1.3, 95% CI= 1.1-1.6, p <0.05). Conclusion: personal and work-related factors were more prevalent in informal group and the elderly person’s dependence interferes with the increase in musculoskeletal symptoms of caregivers.

Factors associated with presenteeism in nursing workers

ABSTRACT Objective: to analyze factors associated with presenteeism in nursing workers with sociodemographic variables, health and work conditions, productivity and musculoskeletal symptoms. Methods: this is a cross-sectional, descriptive and analytical study, with 306 nursing workers from a hospital and municipal emergency room in a Brazilian capital. The Stanford Presenteeism Scale, the Work Limitations Questionnaire, the Nordic Musculoskeletal Questionnaire and a demographic questionnaire on nursing professionals’ working conditions and health were used. Bivariate and multivariate analyzes were performed, respecting a significance level of 5%. Results: presenteeism was found in 43.8% of professionals and significant associations with CLT work (p=0.002), workplace - Intensive Care Units (p=0.008), physical exercise twice a week (p=0.008), presence of musculoskeletal symptoms, with low back pain being representative (p=0.001). The productivity loss was 8.8. Conclusions: the study confirms a high rate of presenteeism among nursing workers.