scholarly journals Thromboxane A2 Receptor

2020 ◽  
Author(s):  
Keyword(s):  
Thromboxane A2 ◽  
Thromboxane A2 Receptor

Carrier-Mediated Active Transport of a Novel Thromboxane A2 Receptor Antagonist [2-(4-Chlorophenylsulfonylaminomethyl)indan-5-yl]acetate (Z-335) into Rat Liver

2002 ◽  
Vol 30 (5) ◽  
pp. 498-504 ◽  
Author(s):  
Yoshihiro Kawabata ◽  
Shigeru Furuta ◽  
Yutaka Shinozaki ◽  
Tadashi Kurimoto ◽  
Ryuichiro Nishigaki
Keyword(s):  
Receptor Antagonist ◽  
Active Transport ◽  
Rat Liver ◽  
Thromboxane A2 ◽  
Thromboxane A2 Receptor

scholarly journals Thromboxane A2 receptor blockade improves renal function and histopathology in the post-obstructive kidney

1994 ◽  
Vol 45 (1) ◽  
pp. 185-192 ◽  
Author(s):  
Craig A. Rinder ◽  
Perry V. Halushka ◽  
Mary Ann Sens ◽  
David W. Ploth
Keyword(s):  
Renal Function ◽  
Thromboxane A2 ◽  
Receptor Blockade ◽  
Thromboxane A2 Receptor

scholarly journals Flavonoids inhibit platelet function through binding to the thromboxane A2 receptor

2005 ◽  
Vol 3 (2) ◽  
pp. 369-376 ◽  
Author(s):  
J. A. GUERRERO ◽  
M. L. LOZANO ◽  
J. CASTILLO ◽  
O. BENAVENTE-GARCIA ◽  
V. VICENTE ◽  
...  
Keyword(s):  
Platelet Function ◽  
Thromboxane A2 ◽  
Thromboxane A2 Receptor

Lung injury in a surfactant-deficient lung is modified by indomethacin

1990 ◽  
Vol 69 (6) ◽  
pp. 2067-2071 ◽  
Author(s):  
R. Burger ◽  
D. Fung ◽  
A. C. Bryan
Keyword(s):  
Pulmonary Hypertension ◽  
Lung Injury ◽  
Thromboxane A2 ◽  
Neutrophil Infiltration ◽  
Lung Lavage ◽  
Thromboxane A2 Receptor ◽  
Beneficial Effects ◽  
Thromboxane Receptor ◽  
Pulmonary Arterial ◽  
Arterial Po2

Repetitive total lung lavage in adult rabbits leads to a reproducible severe surfactant-deficient lung injury. Hypoxemia requiring mechanical ventilation occurs, accompanied by a substantial pulmonary hypertension, a large intra-alveolar protein leak, peripheral neutropenia, and pathological features of marked neutrophil infiltration with extensive hyaline membrane formation. Pretreatment with indomethacin abolishes postlavage pulmonary hypertension, preserves a slightly better lung function with higher arterial PO2, and prevents the postlavage peripheral neutropenia found in untreated animals. Pretreatment with a thromboxane A2 receptor blocker (L 655,240, Merck Frosst, Canada) also completely attenuated pulmonary hypertension, providing evidence that thromboxane A2 mediates pulmonary arterial hypertension after lung lavage. However, specific thromboxane receptor blockade had no other long-lasting beneficial effects on the ongoing injury in this model.

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