This chapter describes a system dynamics model developed for forecasting, prioritization, and distribution of critical supplies during relief operations in case of a hurricane event, while integrating GIS information. Development of alternates' routes selection through vehicle routing procedures and the results incorporation into this system dynamics model allows decisions about the operation in case of a major catastrophe and any preparation for future events. The model developed is also able to (1) establish people's decision and transportation characteristics that determine evacuation time; (2) simulate the behavior of key variables due to the relation between hazard level and people's decision to evacuate; (3) estimate for each natural hazard level the time frequency to order and the order size of each relief supply to be needed in shelters and points of distribution; and (4) reveal which routes cause more delays during relief supplies distribution.