scholarly journals Curcumin Effects on Memory Impairment and Restoration of Irregular Neuronal Distribution in the Hippocampal CA1 Region After Global Cerebral Ischemia in Male Rats

2019 ◽  
pp. 527-540 ◽  
Author(s):  
Leila Kamali Dolatabadi ◽  
Masoumeh Emamghoreishi ◽  
Mohammad Reza Namavar ◽  
Hamze Badeli Sarkala
Keyword(s):  
Cerebral Ischemia ◽  
Memory Impairment ◽  
Male Rats ◽  
Global Cerebral Ischemia ◽  
Ca1 Region ◽  
Hippocampal Ca1 Region ◽  
Hippocampal Ca1 ◽  
Neuronal Distribution

scholarly journals Photobiomodulation Promotes Hippocampal CA1 NSC Differentiation Toward Neurons and Facilitates Cognitive Function Recovery Involving NLRP3 Inflammasome Mitigation Following Global Cerebral Ischemia

2021 ◽  
Vol 15 ◽  
Author(s):  
Sihan Guo ◽  
Ruimin Wang ◽  
Jiewei Hu ◽  
Liping Sun ◽  
Xinru Zhao ◽  
...  
Keyword(s):  
Cognitive Function ◽  
Cerebral Ischemia ◽  
Ischemia Reperfusion ◽  
Neurological Recovery ◽  
Male Rats ◽  
Global Cerebral Ischemia ◽  
Inflammasome Activation ◽  
Ca1 Region ◽  
Hippocampal Ca1 Region ◽  
Hippocampal Ca1

Our recent study revealed that photobiomodulation (PBM) inhibits delayed neuronal death by preserving mitochondrial dynamics and function following global cerebral ischemia (GCI). In the current study, we clarified whether PBM exerts effective roles in endogenous neurogenesis and long-lasting neurological recovery after GCI. Adult male rats were treated with 808 nm PBM at 20 mW/cm2 irradiance for 2 min on cerebral cortex surface (irradiance ∼7.0 mW/cm2, fluence ∼0.8 J/cm2 on the hippocampus) beginning 3 days after GCI for five consecutive days. Cognitive function was evaluated using the Morris water maze. Neural stem cell (NSC) proliferation, immature neurons, and mature neurons were examined using bromodeoxyuridine (BrdU)-, doublecortin (DCX)-, and NeuN-staining, respectively. Protein expression, such as NLRP3, cleaved IL1β, GFAP, and Iba1 was detected using immunofluorescence staining, and ultrastructure of astrocyte and microglia was observed by transmission electron microscopy. The results revealed that PBM exerted a markedly neuroprotective role and improved spatial learning and memory ability at 58 days of ischemia/reperfusion (I/R) but not at 7 days of reperfusion. Mechanistic studies revealed that PBM suppressed reactive astrocytes and maintained astrocyte regeneration at 7 days of reperfusion, as well as elevated neurogenesis at 58 days of reperfusion, as evidenced by a significant decrease in the fluorescence intensity of GFAP (astrocyte marker) but unchanged the number of BrdU-GFAP colabeled cells at the early timepoint, and a robust elevation in the number of DCX-NeuN colabeled cells at the later timepoint in the PBM-treated group compared to the GCI group. Notably, PBM treatment protected the ultrastructure of astrocyte and microglia cells at 58 days but not 7 days of reperfusion in the hippocampal CA1 region. Furthermore, PBM treatment significantly attenuated the GCI-induced immunofluorescence intensity of NLRP3 (an inflammasome component), cleaved IL1β (reflecting inflammasome activation) and Iba1, as well as the colocalization of NLRP3/GFAP or cleaved IL-1β/GFAP, especially in animals subjected to I/R at 58 days. Taken together, PBM treatment performed postischemia exerted a long-lasting protective effect on astrocytes and promoted endogenous neurogenesis in the hippocampal CA1 region, which might contribute to neurological recovery after GCI.

Delayed activation and regulation of MKK7 in hippocampal CA1 region following global cerebral ischemia in rats

Life Sciences ◽  
2003 ◽  
Vol 74 (1) ◽  
pp. 37-45 ◽  
Author(s):  
Quanguang Zhang ◽  
Hui Tian ◽  
Xinzhen Fu ◽  
Guangyi Zhang
Keyword(s):  
Cerebral Ischemia ◽  
Global Cerebral Ischemia ◽  
Ca1 Region ◽  
Hippocampal Ca1 Region ◽  
Hippocampal Ca1

Rapid decrease of high affinity ouabain binding sites in hippocampal CA1 region following short-term global cerebral ischemia in rat

1989 ◽  
Vol 490 (1) ◽  
pp. 170-173 ◽  
Author(s):  
Sofia I. Pylova ◽  
Joanna Majkowska ◽  
Wojciech Hilgier ◽  
Andrzej Kapuścinśki ◽  
Jan Albrecht
Keyword(s):  
Cerebral Ischemia ◽  
Binding Sites ◽  
Rapid Decrease ◽  
Global Cerebral Ischemia ◽  
Ouabain Binding ◽  
Short Term ◽  
High Affinity ◽  
Ca1 Region ◽  
Hippocampal Ca1 Region ◽  
Hippocampal Ca1

scholarly journals Rat B2Sequences Are Induced in the Hippocampal CA1 Region After Transient Global Cerebral Ischemia

1999 ◽  
Vol 274 (40) ◽  
pp. 28674-28681 ◽  
Author(s):  
Xiaodong Liu ◽  
James A. Clemens ◽  
Tinggui Yin ◽  
Diane T. Stephenson ◽  
Edward M. Johnstone ◽  
...  
Keyword(s):  
Cerebral Ischemia ◽  
Global Cerebral Ischemia ◽  
Ca1 Region ◽  
Hippocampal Ca1 Region ◽  
Transient Global Cerebral Ischemia ◽  
Hippocampal Ca1
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