scholarly journals The Mysteries That Surround Kawasaki Disease: A Literature Review

Author(s):  
Karoline Rossi ◽  
Danilo José Silva Moreira ◽  
Juliana Brito da Fonseca ◽  
Suzana dos Santos Vasconcelos ◽  
Vinicius Faustino Lima de Oliveira ◽  
...  

Kawasaki disease (KD) or Mucocutaneous Lymph node Syndrome is a systemic vasculitis, which mainly affects children under five years of age with Asian descent, but can also reach other age groups, as well as any other breed. The clinical picture of KD has three stages: acute febrile stage, in which conjunctival congestion, oral mucositis, erythema, flaking, polymorphic rash and laterocervical lymphadenopathy, appear as main symptoms; the subacute stage, which occurs at the end of fever, and leads to the appearance of skin flaking in the limbs, arthritis, arthralgia and thrombocytosis and finally the stage of convalescence that arises when symptoms are almost dissipating and continues until their normalization. The most used treatment occurs from the administration of intravenous immunoglobulin, which for better prognosis of the pathology should be initiated early.

1982 ◽  
Vol 5 (10) ◽  
pp. 555-559 ◽  
Author(s):  
T. Takamoto ◽  
A. Niwa ◽  
K. Taniguchi ◽  
J. Takeuchi

PEDIATRICS ◽  
1981 ◽  
Vol 67 (5) ◽  
pp. 741-743
Author(s):  
Alan M. Krensky ◽  
William Berenberg ◽  
Karen Shanley ◽  
Edmond J. Yunis

HLA antigens were evaluated in 27 patients with mucocutaneous lymph node symdrome (Kawasaki disease) in the Boston area. In contrast to previous Japanese studies, no incidence of HLA-Bw22 was found. A significant increase (P .002), however, in HLA-Bw51 was found in the patients with mucocutaneous lymph node syndrome as compared to an appropriate control population. To our knowledge, this is only the second disease associated with HLA-B5 specificity. The observations illustrate the lack of unified genetic predisposition for a disease in two ethnic groups, white and Japanese. Such findings may have genetic implications regarding interhuman variation in immune responsiveness.


1990 ◽  
Vol 77 (11) ◽  
pp. 1273-1274 ◽  
Author(s):  
R. A. Wheeler ◽  
A. S. Najmaldin ◽  
M. Soubra ◽  
D. M. Griffiths ◽  
D. M. Burge ◽  
...  

1980 ◽  
Vol 45 (4) ◽  
pp. 797-805 ◽  
Author(s):  
Hisayoshi Fujiwara ◽  
Cheng-Hsiung Chen ◽  
Takako Fujiwara ◽  
Kenya Nishioka ◽  
Chuichi Kawai ◽  
...  

1991 ◽  
Vol 1 (3) ◽  
pp. 212-220 ◽  
Author(s):  
Shiro Naoe ◽  
Kazutoshi Shibuya ◽  
Kei Takahashi ◽  
Megumi Wakayama ◽  
Hirotake Masuda ◽  
...  

In about 1967, a new clinical entity in infants and children was described in Japan. It was an acute febrile illness associated with engorgement of the conjunctivas, labial erythema, and swelling of the deep cervical lymph nodes without suppuration. This disease is usually called the acute febrile mucocutaneous lymph node syndrome or, more simply, Kawasaki disease.


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