31. The Validation of Occupational Exposure Assessments Using Industrial Hygiene Measurements

2002 ◽  
Author(s):  
J. Coble
2002 ◽  
Vol 21 (7) ◽  
pp. 397-398
Author(s):  
Sl Brown

Although demonstrated evidence for hormesis of an agent could be important in setting occupational exposure limits (OELs) for industrial hygiene, several practical problems may limit the utility of toxicologic testing for hormesis. This commentary responds to the lead article of this section, in which Jayjock and Lewis propose using the results of tests for hormesis to guide the establishment of OELs. The principal difficulties may include: a different mechanism or even a different effect leading to the conclusion of hormesis; distinction between a threshold for a health effect and a crossover point in the dose response relationship; estimation of threshold or crossover point from limited test data and estimation of slope at this point; sensitivity of tests for hormesis; and cost of testing. Nevertheless, the proposals of Jayjock and Lewis have considerable merit, and exploratory testing could be useful.


Author(s):  
Andrea Martinelli ◽  
Fabiola Salamon ◽  
Maria Luisa Scapellato ◽  
Andrea Trevisan ◽  
Liviano Vianello ◽  
...  

The adverse effects associated with exposure to flour dust have been known since the 1700s. The aim of the study was to assess the occupational exposure to flour dust in Italian facilities, identify the activities characterized by the highest exposure, and provide information to reduce workers’ exposure. The study was performed in different facilities such as flourmills (n = 2), confectioneries (n = 2), bakeries (n = 24), and pizzerias (n = 2). Inhalable flour dust was assessed by personal and area samplings (n = 250) using IOM (Institute of Occupational Medicine) samplers. The results showed personal occupational exposure to flour dust over the American Conference of Governmental Industrial Hygiene (ACGIH) and the Scientific Committee on Occupational Exposure Limit (SCOEL) occupational limits (mean 1.987 mg/m3; range 0.093–14.055 mg/m3). The levels were significantly higher for dough makers in comparison to the dough formers and packaging area subjects. In four bakeries the industrial hygiene surveys were re-performed after some control measures, such as installation of a sleeve to the end of pipeline, a lid on the mixer tub or local exhaust ventilation system, were installed. The exposure levels were significantly lower than those measured before the introduction of control measures. The exposure level reduction was observed not only in the dough making area but also in all bakeries locals.


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