scholarly journals Impact of hospital experience on the quality of tyrosine kinase inhibitor response monitoring and consequence for chronic myeloid leukemia patient survival

Haematologica ◽  
2017 ◽  
Vol 102 (12) ◽  
pp. e486-e489 ◽  
Author(s):  
Inge G.P. Geelen ◽  
Noortje Thielen ◽  
Jeroen J.W.M. Janssen ◽  
Mels Hoogendoorn ◽  
Tanja J.A. Roosma ◽  
...  
2021 ◽  
Author(s):  
Awni Alshurafa ◽  
Ahmed Abdalhadi ◽  
Deena Mudawi ◽  
Mohamed A. Yassin

Abstract Hepatitis B virus reactivation is a well-known risk in cancer patients who are receiving cytotoxic chemotherapy and may result in different forms of liver injury including fulminant liver failure and death. There are increasing concerns regarding the risk of Hepatitis B reactivation among chronic myeloid leukemia patients who are receiving tyrosine kinase inhibitors. Reactivation risk is not limited to chronic carrier patients but also involves people who have previous Hepatitis B virus infection. This report describes the importance of starting hepatitis B prophylaxis in a newly diagnosed chronic myeloid leukemia patient who was found to have positive hepatitis B anticore antibody before starting tyrosine kinase inhibitor.


2013 ◽  
Vol 13 (7) ◽  
pp. 755-767 ◽  
Author(s):  
Domenico Russo ◽  
Michele Malagola ◽  
Cristina Skert ◽  
Carla Filì ◽  
Cesare Bergonzi ◽  
...  

2019 ◽  
Vol 4 (1-2) ◽  
pp. 41-45 ◽  
Author(s):  
Takeo Koshida ◽  
Sylvia Wu ◽  
Hitoshi Suzuki ◽  
Rimda Wanchoo ◽  
Vanesa Bijol ◽  
...  

Dasatinib is the second-generation tyrosine kinase inhibitor used in the treatment of chronic myeloid leukemia. Proteinuria has been reported with this agent. We describe two kidney biopsy–proven cases of dasatinib-induced thrombotic microangiopathy that responded to stoppage of dasatinib and using an alternate tyrosine kinase inhibitor. Certain specific tyrosine kinase inhibitors lead to endothelial injury and renal-limited thrombotic microangiopathy. Hematologists and nephrologists need to be familiar with this off-target effect of dasatinib.


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