scholarly journals Tacrolimus Induced Early Graft Dysfunction Secondary to Acute Tubular Necrosis in Renal Transplant Recipient - A Case Report

2012 ◽  
Vol 2 (1) ◽  
pp. 63-65 ◽  
Author(s):  
Md Tariful Hoque ◽  
Palash Mitra ◽  
Tasrina Shamnaz Samdani ◽  
Golzar Hossain ◽  
Zainal Abedin ◽  
...  
Keyword(s):  
Renal Transplant ◽  
Transplant Recipient ◽  
Renal Transplant Recipient ◽  
Acute Tubular Necrosis ◽  
Medical Condition ◽  
Immunosuppressive Agents ◽  
Esrd Patient ◽  
Calcineurin Inhibitors ◽  
Ischaemic Injury ◽  
Tubular Necrosis

Acute tubular necrosis (ATN) is a medical condition involving damage of the tubular cells of the nephron following a toxic or ischaemic injury. If the cause of ATN is removed then recovery is likely. Calcineurin inhibitors (ciclosporin & tacrolimus) are used as immunosuppressive agents in renal transplant recipient. But either of these two drugs can cause acute nephrotoxicity. A 62 years old known diabetic, hypertensive & ESRD patient after undergoing living related donor renal transplantation started passing significant amount of urine, but 12 hrs after transplantation the amount of urine output started to decrease and the patient became anuric after 17hrs of transplantation. Immediately the patient was evaluated thoroughly and calcineurin inhibitor (tacrolimus) was witheld. The patient again started passing urine from 4th POD. DOI: http://dx.doi.org/10.3329/birdem.v2i1.12365 Birdem Med J 2012; 2(1) 63-65

scholarly journals A CASE OF RENAL TRANSPLANT RECIPIENT COMPLICATED WITH CRYPTOCOCCOSIS AND AMPHOTERICIN B INDUCED ACUTE TUBULAR NECROSIS

1977 ◽  
Vol 41 (9) ◽  
pp. 1009-1013 ◽  
Author(s):  
TAKAO MISHIMA ◽  
YUTAKA KOBAYASHI ◽  
MICHIHITO OHKUBO ◽  
FUMIAKI MARUMO ◽  
HIROKUNl YOSHIMURA ◽  
...  
Keyword(s):  
Renal Transplant ◽  
Transplant Recipient ◽  
Renal Transplant Recipient ◽  
Amphotericin B ◽  
Acute Tubular Necrosis ◽  
Tubular Necrosis

A Numerical Scale Comparison of Renal Transplant Recipient Experience with and Opinions about Calcineurin Inhibitors

2004 ◽  
Vol 97 (2) ◽  
pp. c35-c40 ◽  
Author(s):  
G.V. Ramesh Prasad ◽  
Michelle M. Nash ◽  
Philip A. McFarlane ◽  
Jeffrey S. Zaltzman
Keyword(s):  
Renal Transplant ◽  
Transplant Recipient ◽  
Renal Transplant Recipient ◽  
Calcineurin Inhibitors ◽  
Numerical Scale

scholarly journals Slow Recovery from Critical Coronavirus Disease 2019 Pneumonia in an Immunosuppressed Renal Transplant Recipient with Early Acute Cardiorenal Syndrome

2020 ◽  
Vol 10 (6) ◽  
pp. 470-475 ◽  
Author(s):  
Lan Zhu ◽  
Hongge Shu ◽  
Huijun Li ◽  
Tao Qiu ◽  
Jiangqiao Zhou ◽  
...  
Keyword(s):  
Renal Transplant ◽  
Transplant Recipient ◽  
Renal Transplant Recipient ◽  
Immunosuppressive Agents ◽  
Kidney Injury ◽  
Cardiorenal Syndrome ◽  
Renal Transplant Recipients ◽  
Transplant Recipients ◽  
Slow Recovery ◽  
Global Spread

With the global spread of SARS-Cov-2 infections, increasing numbers of COVID-19 cases have been reported in transplant recipients. However, reports are lacking concerning the treatment and prognosis of COVID-19 pneumonia in renal transplant recipients with acute cardiorenal syndrome. We report here the complete clinical course of a renal transplant recipient with critical COVID-19 pneumonia. In the early phase of SARS-Cov-2 infection, the patient exhibited extensive lung lesions and significant acute kidney and heart injuries, which required treatment in the ICU. After correcting the arrhythmia and heart failure, the patient recovered quickly from the acute kidney injury with a treatment of intensive diuresis and strict control of fluid intake. Without cessation of oral immunosuppressive agents, the patient presented a delayed and low antibody response against SARS-Cov-2 and reappeared positive for the virus twice after being discharged. Nevertheless, the patient’s pneumonia continued to improve and he fully recovered in 69 days. This effectively treated case may be meaningful and referable for the treatment of COVID-19 pneumonia in other transplant recipients with acute cardiorenal syndrome.

scholarly journals Metastatic lung adenocarcinoma- associated thrombotic microangiopathy in a renal transplant recipient

2018 ◽  
Vol 11 (1) ◽  
pp. e226707 ◽  
Author(s):  
Eswari Vilayur ◽  
Jillian de Malmanche ◽  
Paul Trevillian ◽  
David Ferreira
Keyword(s):  
Renal Transplant ◽  
Transplant Recipient ◽  
Renal Transplant Recipient ◽  
Thrombotic Microangiopathy ◽  
Calcineurin Inhibitors ◽  
Diagnostic Challenge ◽  
Complement Regulatory Proteins ◽  
Vein Thrombosis ◽  
Metastatic Lung ◽  
Deep Vein

Thrombotic microangiopathy (TMA) after renal transplantation can be a diagnostic challenge. TMA can occur with calcineurin inhibitors, allograft rejection, infection, mutations in complement regulatory proteins and autoimmunity. A 52-year-old male renal transplant recipient presented with extensive deep vein thrombosis. He developed transfusion-dependent microangiopathic haemolytic anaemia with thrombocytopenia. He did not respond calcineurin inhibitor cessation, eculizumab or plasma exchange. ADAMTS13 and complement levels were normal. Infection and autoimmune screens were negative. A diagnosis of metastatic adenocarcinoma was made on bone marrow biopsy. This represents a rare case of malignancy-associated TMA in a renal transplant recipient. Early diagnosis can facilitate the prompt initiation of chemotherapy which is the only treatment option.

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