scholarly journals Unusual and Late Recurrence in Ovarian Adult Granulosa Cell Tumour: A Case Report

2013 ◽  
Vol 23 (2) ◽  
pp. 42-46
Author(s):  
Serajun Noor ◽  
Jashim Uddin Ahmed ◽  
Shahanara Chowdhury ◽  
Zillur Rahman
Keyword(s):  
Granulosa Cell ◽  
Total Abdominal Hysterectomy ◽  
Complete Response ◽  
Late Recurrence ◽  
Abdominal Hysterectomy ◽  
Cell Tumour ◽  
High Survival ◽  
Granulosa Cell Tumour ◽  
Initial Surgery ◽  
Management Protocol

Granulosa cell tumour of ovary are rare hormonally active neoplasm characterized by indolent course, local spread with a preponderance for extremely late recurrence and high survival rate. We report a 60 year old lady presented in 2009 with aggressive looking growth in vulva 16 years after her total abdominal hysterectomy with Bilateral salphingo-ophorectomy with infracolic omentectomy for suspected stage granulosa cell tumour of ovary , confirmed by histopathology. She remained disease free for 13 years and in 2005 underwent resection of retroperitoneal mass with multiple peritoneal implant, confirmed to be a granulosa cell tumour after biopsy. Despite six course adjuvent combination therapy with complete response she presented after 4 years in 2009 with a second recurrence in vulva. She had tumour reductive surgery followed by chemotherapy and hormonal therapy but the disease was progressive. In conclusion late recurrence and repeat recurrence is a hallmark for granulosa cell tumour of ovary, so we emphasis the need for long term follow up and consider the possibility of recurrence when presented with acute abdomen after initial surgery for granulose cell tumour. But there is no standard management protocol and we review this patients treatment in the context of current literature. JCMCTA 2012 ; 23 (2): 42-46

scholarly journals Ovarian Adult Granulosa Cell Tumor – a rare case report

2018 ◽  
Vol 13 (1) ◽  
pp. 57-60
Author(s):  
Rijuta Joshi ◽  
Gehanath Baral ◽  
Karishma Malla
Keyword(s):  
Granulosa Cell ◽  
Abdominal Mass ◽  
Granulosa Cell Tumor ◽  
Total Abdominal Hysterectomy ◽  
Late Recurrence ◽  
Abdominal Hysterectomy ◽  
Cell Tumor ◽  
Rare Case Report ◽  
Stage Ia ◽  
Post Menopausal

Introduction: Adult granulosa cell tumor is a rare tumor which accounts for 1% of all ovarian tumors.  They usually present with postmenopausal bleeding and abdominal mass. Inhibin is used as the tumor marker.Case: A 76 years multiparous post-menopausal women presented with vaginal bleeding for past three years and  painless  huge mass in lower abdomen.  She underwent total abdominal hysterectomy with bilateral salphingo-oophorectomy with bilateral pelvic lymphnode dissection with appendectomy. Histopathology showed the adult granulosa cell tumor with few mitosis, Stage IA. Her postoperative period was uneventful.Conclusion: Surgery is the mainstay of treatment of granulosa cell tumor and chemotherapy is indicated in advanced cases. Although they have better prognosis, life-long follow up is advised to detect late recurrence.

Late Recurrence of Granulosa Cell Tumour Involving the Retroperitoneum and Spleen

2020 ◽  
Vol 18 (4) ◽  
Author(s):  
Padmapriya Balakrishnan ◽  
Vijayan Sharmila ◽  
Thirunavukkarasu Arun Babu
Keyword(s):  
Granulosa Cell ◽  
Late Recurrence ◽  
Cell Tumour ◽  
Granulosa Cell Tumour

DEMONSTRATION OF AN FSH RECEPTOR IN A FUNCTIONING GRANULOSA CELL TUMOUR

1977 ◽  
Vol 85 (3) ◽  
pp. 615-623 ◽  
Author(s):  
Margaret Davy ◽  
P. A. Torjesen ◽  
A. Aakvaag
Keyword(s):  
Granulosa Cell ◽  
Nude Mice ◽  
Late Recurrence ◽  
Cell Tumour ◽  
Fsh Receptor ◽  
Granulosa Cell Tumour ◽  
Hormone Production ◽  
Athymic Nude Mice ◽  
Oestradiol Level ◽  
Plasma Oestradiol

ABSTRACT Hormone production in a patient suffering from a late recurrence of a granulosa cell tumour has been studied pre- and post-operatively, and a vein on the tumour surface was cannulated at operation to collect tumour vein blood for pre-operative studies. Elevation in the plasma oestradiol level and depression in FSH and LH were found pre-operatively, and elevations were found in tumour vein oestradiol and 17α-hydroxyprogsterone. Plasma oestradiol level returned to normal postoperatively whereas FSH and LH levels were persistently depressed. FSH receptors were found in this tumour, and on the basis of this finding, gonadotrophins were given to athymic nude mice in an attempt to support the growth of the granulosa cell tumour implanted in these animals. We demonstrated that gonadotrophins have supported the tumour tissue, but not promoted growth.

NEW VIEWS ON THE HORMONE-PRODUCING MESENCHYMOMAS OF THE OVARIES

1960 ◽  
Vol XXXV (IV) ◽  
pp. 513-517
Author(s):  
W. P. Plate
Keyword(s):  
Granulosa Cell ◽  
Sertoli Cell ◽  
Leydig Cell ◽  
Cell Tumour ◽  
Theca Cell ◽  
Granulosa Cell Tumour ◽  
Sertoli Cell Tumours ◽  
Leydig Cell Tumours

ABSTRACT The hormone-producing mesenchymomas of the ovaries can be divided into androblastomas and gynaecoblastomas. The former are derived from »male« elements, and consist of Sertoli-cell tumours and Leydig-cell tumours. The latter arise from »female« elements and consist of granulosacell tumours and theca-cell tumours. Sertoli-cell tumours and granulosacell tumours produce oestrogens, while Leydig-cell tumours and theca-cell tumours produce oestrogens or androgens. Histologically, androblastomas and gynaecoblastomas are often difficult to distinguish. Since no »female« elements occur in a testicle, a granulosa-cell tumour in a testicle is improbable. Gynandroblastomas, therefore, can only be found in an ovary.

FOXL2 in adult‐type granulosa cell tumour of the ovary: oncogene or tumour suppressor gene?

2021 ◽  
Author(s):  
Jessica A. Pilsworth ◽  
Anne‐Laure Todeschini ◽  
Samantha J. Neilson ◽  
Dawn R. Cochrane ◽  
Daniel Lai ◽  
...  
Keyword(s):  
Granulosa Cell ◽  
Suppressor Gene ◽  
Tumour Suppressor Gene ◽  
Tumour Suppressor ◽  
Cell Tumour ◽  
Granulosa Cell Tumour ◽  
Adult Type

scholarly journals Juvenile granulosa cell tumor

2016 ◽  
Author(s):  
Geetanjali Tuteja ◽  
S. Unmesh ◽  
S. Shree ◽  
S. Rudra ◽  
Keyword(s):  
Granulosa Cell ◽  
Precocious Puberty ◽  
Early Stage ◽  
Pubertal Development ◽  
Granulosa Cell Tumor ◽  
Cell Tumor ◽  
Cell Tumour ◽  
Tumour Resection ◽  
Granulosa Cell Tumour ◽  
Juvenile Granulosa Cell Tumor

The differential diagnosis for precocious puberty in a young female includes peripheral causes. This case report documents a rare cause of isosexual precocious puberty, a juvenile granulosa cell tumour of the ovary–and a brief literature review. A one year-old baby girl presented with mass abdomen, vaginal discharge and rapid onset of pubertal development. She underwent an exploratory laparotomy for tumour resection. Pathology reported a juvenile granulosa cell tumour of the ovary. Early stage granulosa cell tumor surgically treated has good prognosis. Adjuvant chemotherapy is not indicated in this setting.

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