Renal Involvement in Leprosy: A Case Report

Leprosy is a chronic granulomatous multisystem disorder. Renal involvement is one of the dangerous complications of leprosy. Kidneys are usually involved during splanchnic localization of leprosy. The histopathological renal lesion spectrum includes spectrum of glomerulonephritis, renal amyloidosis and interstitial nephritis. Here we report a case of leprosy who presented with diffuse membranoproliferative glomerulonephritis with renal failure. doi: 10.3329/taj.v19i2.3157 TAJ 2006; 19(2): 84-86

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Nierenmanifestationen bei Amyloidose und Sarkoidose

DMW - Deutsche Medizinische Wochenschrift ◽

10.1055/s-0043-106565 ◽

2018 ◽

Vol 143 (02) ◽

pp. 101-109

Author(s):

Jörg Beimler ◽

Martin Zeier

Keyword(s):

Interstitial Nephritis ◽

Inflammatory Diseases ◽

Renal Involvement ◽

Plasma Cell Dyscrasia ◽

Renal Amyloidosis ◽

Al Amyloidosis ◽

Renal Lesion ◽

Aa Amyloidosis ◽

Granulomatous Interstitial Nephritis ◽

Chronic Inflammatory Diseases

AbstractAmyloidosis is a rare disease characterized by extracellular deposition of fibrils. Among the most common forms of systemic amyloidosis with renal involvement are AL-amyloidosis based on plasma cell dyscrasia and AA-amyloidosis in chronic inflammatory diseases. Depending on the affected renal compartment, the clinical appearance of renal amyloidosis varies. The pattern of renal amyloid deposition can be glomerular, interstitial, tubular or even vascular. Renal amyloid deposits are detected by renal biopsy. Patients with glomerular deposits typically show severe nephrotic syndrome with volume overload. Patients with predominantly tubulo-interstitial or vascular deposits typically exhibit lower proteinuria and progressive renal impairment. Treatment strategies for renal amyloidosis are primarily based on the treatment of the underlying disease including chemotherapy or stem cell transplantation in AL-amyloidosis or treatment of chronic inflammatory diseases in AA-amyloidosis. Granulomatous interstitial nephritis is the most common renal lesion occurring in sarcoidosis. Therapy of granulomatous interstitial nephritis is mainly based on the use of glucocorticoids.

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Spontaneous Glomerulonephritis in Dogs: II. Correlation of Glomerulonephritis with Age, Chronic Interstitial Nephritis and Extrarenal Lesions

Veterinary Pathology ◽

10.1177/030098587701400204 ◽

1977 ◽

Vol 14 (2) ◽

pp. 121-127 ◽

Cited By ~ 32

Author(s):

R. Müller-Peddinghaus ◽

G. Trautwein

Keyword(s):

Interstitial Nephritis ◽

Membranoproliferative Glomerulonephritis ◽

Age Groups ◽

Renal Amyloidosis ◽

Morphologic Study ◽

Different Types ◽

End Stage ◽

Chronic Interstitial Nephritis ◽

Slight Damage ◽

Severe Fibrosis

A morphologic study of 103 dogs, including two with renal amyloidosis, showed that different types of diffuse glomerulonephritis are correlated with different age groups. Membranous and membranoproliferative glomerulonephritis were more common in middle-aged and older animals, whereas mesangial lesions were found predominantly in younger dogs and considered to be early glomerular changes. Glomerulonephritis largely occurred independently of interstitial nephritis. The incidence of interstitial lesions was 71%. Chronic interstitial nephritis was rare in dogs under 1 year old. Glomerulonephritis did not seem to induce interstitial nephritis. Glomerulonephritis occurred not only in kidneys with severe interstitial damage, but also in those with slight damage. This indicated that glomerulonephritis occurred independently of interstitial nephritis. In end-stage kidneys with severe fibrosis, mesangial changes seemed to predominate.

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Cyclical hematuria-ureteral endometriosis: a case report

International Journal of Reproduction Contraception Obstetrics and Gynecology ◽

10.18203/2320-1770.ijrcog20181373 ◽

2018 ◽

Vol 7 (4) ◽

pp. 1648

Author(s):

Sindura Ganga Ravula ◽

Harish Shetty ◽

Aparna Rajesh

Keyword(s):

Renal Failure ◽

Case Report ◽

Early Diagnosis ◽

Renal Involvement ◽

High Index ◽

True Incidence ◽

Ureteral Endometriosis ◽

High Index Of Suspicion ◽

Specific Symptoms

Little attention has been paid for the renal involvement in endometriosis, a rare and silent disorder which ultimately lead to renal failure. Involvement most commonly may be limited to single ureter (left one) and it is usually involvement extrinsically. Although cases have been reported in the literature, true incidence of ureteral involvement is still not known. The diagnosis is difficult as the disease has non-specific symptoms. Only high index of suspicion with radiological support would be helpful in early diagnosis. Early cases may be benefited with progestin or Anti-aromatase therapy, most cases need surgery, either laparoscopically or laparotomy.

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Renal involvement as the first symptom of multiple myeloma

10.21203/rs.2.10471/v2 ◽

2019 ◽

Author(s):

Yongjing Du ◽

Ping Zhang ◽

Xiang Zhong ◽

Shasha Chen ◽

Guisen Li ◽

...

Keyword(s):

Multiple Myeloma ◽

Renal Failure ◽

Nephrotic Syndrome ◽

Light Chain ◽

Clinical Laboratory ◽

Renal Involvement ◽

Clinical Manifestations ◽

Renal Amyloidosis ◽

Cast Nephropathy ◽

Immunofixation Electrophoresis

Abstract Background . Renal involvement is a common complication of multiple myeloma (MM). However, most studies have focused on renal failure in MM, and little information is available about the other renal manifestations in MM and their association with immunophenotypes and renal pathology. Methods . We retrospectively analyzed the clinical, laboratory and pathology data of 283 MM patients treated in Sichuan Provincial People’s Hospital, West China, between January 1990 and May 2017. The patients were divided into a renal involvement group (n = 200) and a non-renal involvement group (n = 83). Results. In the renal involvement group, 90 (45.0%) patients were diagnosed with MM in the Nephrology department, and isolated proteinuria, renal failure and nephrotic syndrome were detected in 90(45.0%), 94 (47.0%) and 58 (29.0%) patients, respectively. 135 patients with renal involvement underwent immunofixation electrophoresis, and IgG, IgA, IgD, IgE, pure light chain and nonsecretory MM were detected in 52 (38.5%), 32 (23.7%), 1 (0.7%), 1 (0.7%), 45(33.3%) and 4 (3.0%) patients, respectively. 47 patients without renal involvement also underwent immunofixation electrophoresis, and IgG and IgA MM were found in 24 (51.0%) and 18 (38.3%) patients, respectively. Severe anemia and hypertension, hypercalcemia and pure light chain were more frequent in patients with renal involvement (P < 0.05).9 patients with renal involvement were performed renal biopsy, and cast nephropathy, renal amyloidosis were proved in 5 and 4 patients, respectively. Conclusions. Renal involvement was common at MM diagnosis and had diverse clinical manifestations. The most common clinical manifestations include renal failure, isolated albuminuria and nephrotic syndrome. Nephrologists should rule out MM in patients presenting with renal involvement.

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Renal involvement as the first symptom of multiple myeloma

10.21203/rs.2.10471/v1 ◽

2019 ◽

Author(s):

Yongjing Du ◽

Ping Zhang ◽

Xiang Zhong ◽

Shasha Chen ◽

Guisen Li ◽

...

Keyword(s):

Multiple Myeloma ◽

Renal Failure ◽

Light Chain ◽

Clinical Laboratory ◽

Renal Involvement ◽

Clinical Manifestations ◽

Renal Amyloidosis ◽

Cast Nephropathy ◽

Light Chain Disease ◽

Immunofixation Electrophoresis

Abstract Background Renal involvement is a common complication of multiple myeloma (MM). However, most studies have focused on renal failure in MM, and little information is available about the other renal manifestations in MM and their association with immunophenotypes and renal pathology. Methods We retrospectively analyzed the clinical, laboratory and pathology data of 283 MM patients treated in Sichuan Provincial People’s Hospital, West China, between January 1990 and May 2017. The patients were divided into a renal involvement group (n = 200) and a non-renal involvement group (n = 83). Results In the renal involvement group, 90 (45.0%) patients were diagnosed with MM in the Nephrology department, and isolated proteinuria, renal failure and nephrotic syndrome were detected in 90(45.0%), 94 (47.0%) and 53 (27.0%) patients, respectively. 135 patients with renal involvement underwent immunofixation electrophoresis, and IgG, IgA, IgD, IgE, pure light chain and nonsecretory MM were detected in 52 (38.5%), 32 (23.7%), 1 (0.7%), 1 (0.7%), 45(33.3%) and 4 (3.0%) patients, respectively. 47 patients without renal involvement also underwent immunofixation electrophoresis, and IgG and IgA MM were found in 24 (51.0%) and 18 (38.3%) patients, respectively. Severe anemia and hypertension, hypercalcemia and pure light chain disease were more frequent in patients with renal involvement (P < 0.05). 9 patients with renal involvement were performed renal biopsy, and cast nephropathy and renal amyloidosis were proved in 5(55.6%) and 4(44.4%) patients, respectively. Conclusions Renal involvement was common at MM diagnosis and had diverse clinical manifestations. Nephrologists should rule out MM in patients presenting with renal involvement.

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RENAL HISTOPATHOLOGICAL FINDINGS IN DOGS WITH VISCERAL LEISHMANIASIS

Revista do Instituto de Medicina Tropical de São Paulo ◽

10.1590/s0036-46652013000200008 ◽

2013 ◽

Vol 55 (2) ◽

pp. 113-116 ◽

Cited By ~ 11

Author(s):

Rosangela Silva Rigo ◽

Cristiano Marcelo Espínola Carvalho ◽

Michael Robin Honer ◽

Gisele Braziliano de Andrade ◽

Iandara Shetter Silva ◽

...

Keyword(s):

Renal Failure ◽

Visceral Leishmaniasis ◽

Focal Segmental Glomerulosclerosis ◽

Membranoproliferative Glomerulonephritis ◽

Inflammatory Infiltrate ◽

Renal Involvement ◽

Serological Diagnosis ◽

Canine Visceral Leishmaniasis ◽

Significant Difference ◽

Inflammatory Changes

Visceral leishmaniasis affects various organs including the kidneys; which can lead to renal failure and death. In order to verify this renal involvement, material was evaluated from 100 dogs naturally infected and with serological diagnosis of canine visceral leishmaniasis (CVL). Inflammatory changes were present in 25.3% of the tubules, in 67.0% of interstitium and in 52.0% of glomeruli. There was no significant difference (p > 0.05) between the presence of glomerulonephritis in symptomatic and oligosymptomatic dogs. The membranous and membranoproliferative glomerulonephritis were the most frequent, both with 18.0% frequency, followed by focal segmental glomerulosclerosis with 14.0%. Changes such as cylindruria, tubular and fibrosis hypertrophy, periglomerular inflammatory infiltrate, and multifocal and diffuse peritubular inflammatory infiltrate were observed. The findings are consistent with those of other authors indicating that renal involvement is common in CVL and the standards of membranous and membranoploriferative glomerulonephritis, as well as the tubulointerstitial involvement, are frequent.

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Amiloidose Renal em Paciente Portadora de HIV: Relato de Caso/ Renal Amyloidosis in a Patient with HIV: Case Report

REVISTA CIÊNCIAS EM SAÚDE ◽

10.21876/rcsfmit.v4i4.266 ◽

1970 ◽

Vol 4 (4) ◽

pp. 73-79

Author(s):

Daiana Knopp Barbosa ◽

Deborah Rodrigues Matteucci ◽

Pablo Girardelli Mendonça Mesquita

Keyword(s):

Renal Failure ◽

Renal Function ◽

Clinical Case ◽

Clinical Symptoms ◽

Renal Amyloidosis ◽

Renal Lesion ◽

Rare Disorders ◽

Target Organs ◽

Venous Fistula ◽

Good Patency

A lesão renal clássica do paciente portador de HIV é a glomeruloesclerose segmentar e focal colapsante; no entanto, aproximadamente 40% dos pacientes apresentam diagnóstico histológico diferencial, incluindo amiloidose renal. Amiloidose é um termo aplicado a um grupo heterogêneo de doenças raras, caracterizado pelo depósito extracelular de proteínas amilóides, causando disfunção de órgãos-alvo e uma ampla gama de sintomas clínicos. O trabalho tem como objetivo relatar e discutir o caso clínico de uma paciente portadora de HIV associado a amiloidose renal, que permanece com alteração na função renal, sendo submetida a sessões de hemodiálise três vezes por semana, além do acompanhamento periódico. Conclui-se que a amiloidose renal corresponde a aproximadamente 4% dos casos de nefropatia associado ao HIV, demonstrando a importância da biópsia renal para a confirmação do diagnóstico histológico da doença. Palavras-chave: Amiloidose renal, Insuficiência renal, HIV ABSTRACTThe classic renal lesion of patients with HIV is the focal segmental glomerulosclerosis collapsing, however, approximately 40% of patients have histologic differential diagnosis, including renal amyloidosis. Amyloidosis is a term applied to a heterogeneous group of rare disorders characterized by extracellular deposit of amyloid proteins, causing dysfunction of target organs and a broad range of clinical symptoms. The work aims to reportand discuss the clinical case of a patient with HIV-associated renal amyloidosis that remained with abnormal renal function, underwent arterial-venous fistula preparation with good patency and was maintained on hemodialysis sessions three times a week, in addition to outpatient regular monitoring. We conclude that renal amyloidosis accounts for approximately 4% of cases of HIV-associated nephropathy, demonstrating the importance of renal biopsy to confirm the histological diagnosis. Keywords: Renal amyloidosis, Renal failure, HIV.

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