Plasma Neutrophil Gelatinase-associated Lipocalin and Leukocyte Differential Count in Children with Febrile Urinary Tract Infection

Purpose: We aimed to study the association of plasma neutrophil gelatinase-associated lipocalin (pNGAL) and leukocyte differential count in children with febrile urinary tract infection (UTI).Methods: Medical records of 154 children aged 1 month to 13 years with febrile UTI who were hospitalized were retrospectively reviewed. Associations between pNGAL levels and blood leukocyte differential count at admission and after 48 hours of treatment were investigated in children with or without acute pyelonephritis (APN).Results: The APN group (n=82) showed higher pNGAL levels, neutrophil count, monocyte count, and neutrophil-to-lymphocyte ratio (NLR), compared to the non-APN group (n=72) (all P<0.05). After adjustment for age and sex, pNGAL showed positive correlations with neutrophil count and NLR in both groups (all P<0.05). Additionally, it was correlated with the monocyte-to-lymphocyte ratio (MLR) only in the APN group (P<0.05). Before and after treatment, pNGAL was positively correlated with neutrophil count, NLR, and MLR in patients with APN while it was related with neutrophil count and NLR in those without APN (all P<0.05). Areas under the receiver operating curve of pNGAL, neutrophil count, NLR, and MLR for predicting APN were 0.804, 0.760, 0.730, and 0.636, respectively (all P<0.05). Only pNGAL was independently associated with the presence of APN in a multivariable logistic regression analysis (P<0.05).Conclusion: In children with febrile UTIs, pNGAL might be associated with leukocyte differential count and the presence of APN.

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Reduced urinary excretion of neutrophil gelatinase-associated lipocalin as a risk factor for recurrence of febrile urinary tract infection in children

Pediatric Nephrology ◽

10.1007/s00467-020-04863-2 ◽

2021 ◽

Author(s):

Sohsaku Yamanouchi ◽

Takahisa Kimata ◽

Yuko Akagawa ◽

Shohei Akagawa ◽

Jiro Kino ◽

...

Keyword(s):

Urinary Tract Infection ◽

Risk Factor ◽

Urinary Tract ◽

Tract Infection ◽

Urinary Excretion ◽

Febrile Urinary Tract Infection ◽

Neutrophil Gelatinase Associated Lipocalin ◽

Neutrophil Gelatinase ◽

Risk Factor For Recurrence

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Plasma Neutrophil Gelatinase-Associated Lipocalin as a Predictor of Renal Parenchymal Involvement in Infants With Febrile Urinary Tract Infection: A Preliminary Study

Annals of Laboratory Medicine ◽

10.3343/alm.2018.38.5.425 ◽

2018 ◽

Vol 38 (5) ◽

pp. 425-430 ◽

Cited By ~ 5

Author(s):

Bo Ae Yun ◽

Eun Mi Yang ◽

Chan Jong Kim

Keyword(s):

Urinary Tract Infection ◽

Urinary Tract ◽

Tract Infection ◽

Febrile Urinary Tract Infection ◽

Neutrophil Gelatinase Associated Lipocalin ◽

Preliminary Study ◽

Neutrophil Gelatinase

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Diagnostic accuracy of urine neutrophil gelatinase-associated lipocalin and urine kidney injury molecule-1 as predictors of acute pyelonephritis in young children with febrile urinary tract infection

Central European Journal of Immunology ◽

10.5114/ceji.2019.87069 ◽

2019 ◽

Vol 44 (2) ◽

pp. 174-180 ◽

Cited By ~ 1

Author(s):

Grażyna Krzemień ◽

Małgorzata Pańczyk-Tomaszewska ◽

Iwona Kotuła ◽

Urszula Demkow ◽

Agnieszka Szmigielska

Keyword(s):

Urinary Tract Infection ◽

Urinary Tract ◽

Tract Infection ◽

Diagnostic Accuracy ◽

Acute Pyelonephritis ◽

Kidney Injury ◽

Febrile Urinary Tract Infection ◽

Neutrophil Gelatinase Associated Lipocalin ◽

Kidney Injury Molecule 1 ◽

Neutrophil Gelatinase

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Prediction of renal cortical defect and scar using neutrophil-to-lymphocyte ratio in children with febrile urinary tract infection

Nuklearmedizin ◽

10.3413/nukmed-0878-17-01 ◽

2017 ◽

Vol 56 (03) ◽

pp. 109-114 ◽

Cited By ~ 3

Author(s):

Jeong Won Lee ◽

Joon Soo Park ◽

Kyeong Bae Park ◽

Gyeong Hee Yoo ◽

Seung Soo Kim ◽

...

Keyword(s):

Urinary Tract Infection ◽

Urinary Tract ◽

Tract Infection ◽

Neutrophil To Lymphocyte Ratio ◽

Febrile Urinary Tract Infection ◽

Lymphocyte Ratio ◽

Cortical Defect ◽

Febrile Uti ◽

Dmsa Scan

SummaryAim: This study is aimed to evaluate the predictive value of the neutrophil-to-lymphocyte ratio (NLR) for cortical defect on initial and follow-up Tc-99m dimercaptosuccinic acid (DMSA) scan in children with the first febrile urinary tract infection (UTI). Methods: We retrospectively enrolled 179 children with the first febrile UTI who underwent DMSA scan and laboratory tests. In patients with abnormal DMSA scan findings, follow-up DMSA scan was performed at least 6 months after the initial scan. All DMSA scans were classified as negative and positive cortical defects. Multiple logistic regression analyses were performed to identify the risk factors for cortical defect on initial and follow-up DMSA scan. Results: Cortical defects on initial DMSA scan were noted in 133 patients. Vesicoureteral reflux (VUR), white blood cell count, absolute neutrophil count, NLR, and serum C-reactive protein level were independent predictive factors for positive cortical defect on initial DMSA scan (p < 0.050). On follow-up DMSA scan, 24 of the 133 patients showed persistent cortical defects, and only VUR was significantly associated with persistent cortical defect (p = 0.002). In 84 patients who showed cortical defect on initial scan and absence of VUR, only NLR was significantly associated with persistent cortical defect on follow-up scan (p = 0.025). Conclusion: NLR was significantly associated with persistent cortical defect on follow-up DMSA scan in patients without VUR, as well as positive cortical defect on initial scan.

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