Reduced urinary excretion of neutrophil gelatinase-associated lipocalin as a risk factor for recurrence of febrile urinary tract infection in children

2021 ◽  
Author(s):  
Sohsaku Yamanouchi ◽  
Takahisa Kimata ◽  
Yuko Akagawa ◽  
Shohei Akagawa ◽  
Jiro Kino ◽  
...  
Keyword(s):  
Urinary Tract Infection ◽  
Risk Factor ◽  
Urinary Tract ◽  
Tract Infection ◽  
Urinary Excretion ◽  
Febrile Urinary Tract Infection ◽  
Neutrophil Gelatinase Associated Lipocalin ◽  
Neutrophil Gelatinase ◽  
Risk Factor For Recurrence

scholarly journals Plasma Neutrophil Gelatinase-associated Lipocalin and Leukocyte Differential Count in Children with Febrile Urinary Tract Infection

2021 ◽  
Vol 25 (2) ◽  
pp. 84-91
Author(s):  
Min Hwa Son ◽  
Hyung Eun Yim ◽  
Kee Hwan Yoo
Keyword(s):  
Urinary Tract Infection ◽  
Urinary Tract ◽  
Tract Infection ◽  
Neutrophil Count ◽  
Differential Count ◽  
Febrile Urinary Tract Infection ◽  
Lymphocyte Ratio ◽  
Neutrophil Gelatinase Associated Lipocalin ◽  
Leukocyte Differential Count ◽  
Neutrophil Gelatinase

Purpose: We aimed to study the association of plasma neutrophil gelatinase-associated lipocalin (pNGAL) and leukocyte differential count in children with febrile urinary tract infection (UTI).Methods: Medical records of 154 children aged 1 month to 13 years with febrile UTI who were hospitalized were retrospectively reviewed. Associations between pNGAL levels and blood leukocyte differential count at admission and after 48 hours of treatment were investigated in children with or without acute pyelonephritis (APN).Results: The APN group (n=82) showed higher pNGAL levels, neutrophil count, monocyte count, and neutrophil-to-lymphocyte ratio (NLR), compared to the non-APN group (n=72) (all P<0.05). After adjustment for age and sex, pNGAL showed positive correlations with neutrophil count and NLR in both groups (all P<0.05). Additionally, it was correlated with the monocyte-to-lymphocyte ratio (MLR) only in the APN group (P<0.05). Before and after treatment, pNGAL was positively correlated with neutrophil count, NLR, and MLR in patients with APN while it was related with neutrophil count and NLR in those without APN (all P<0.05). Areas under the receiver operating curve of pNGAL, neutrophil count, NLR, and MLR for predicting APN were 0.804, 0.760, 0.730, and 0.636, respectively (all P<0.05). Only pNGAL was independently associated with the presence of APN in a multivariable logistic regression analysis (P<0.05).Conclusion: In children with febrile UTIs, pNGAL might be associated with leukocyte differential count and the presence of APN.

scholarly journals Serum neutrophil gelatinase-associated lipocalin for predicting acute pyelonephritis in infants with urinary tract infection

2019 ◽  
Vol 44 (1) ◽  
pp. 45-50 ◽  
Author(s):  
Grażyna Krzemień ◽  
Małgorzata Pańczyk-Tomaszewska ◽  
Iwona Kotuła ◽  
Urszula Demkow ◽  
Agnieszka Szmigielska
Keyword(s):  
Urinary Tract Infection ◽  
Urinary Tract ◽  
Tract Infection ◽  
Acute Pyelonephritis ◽  
Neutrophil Gelatinase Associated Lipocalin ◽  
Neutrophil Gelatinase

Increased Urinary Neutrophil Gelatinase Associated Lipocalin Levels in a Rat Model of Upper Urinary Tract Infection

2009 ◽  
Vol 181 (5) ◽  
pp. 2326-2331 ◽  
Author(s):  
Manabu Ichino ◽  
Yoko Kuroyanagi ◽  
Mamoru Kusaka ◽  
Terumi Mori ◽  
Kiyohito Ishikawa ◽  
...  
Keyword(s):  
Urinary Tract Infection ◽  
Urinary Tract ◽  
Tract Infection ◽  
Rat Model ◽  
Upper Urinary Tract ◽  
Neutrophil Gelatinase Associated Lipocalin ◽  
Neutrophil Gelatinase

scholarly journals Pelvic floor dysfunction is not a risk factor for febrile urinary tract infection in adults

2009 ◽  
Vol 105 (12) ◽  
pp. 1689-1695 ◽  
Author(s):  
Cees Van Nieuwkoop ◽  
Petra J. Voorham-van der Zalm ◽  
Anne-Marike Van Laar ◽  
Henk W. Elzevier ◽  
Jeanet W. Blom ◽  
...  
Keyword(s):  
Urinary Tract Infection ◽  
Risk Factor ◽  
Urinary Tract ◽  
Tract Infection ◽  
Pelvic Floor ◽  
Pelvic Floor Dysfunction ◽  
Febrile Urinary Tract Infection

scholarly journals Urinary neutrophil gelatinase associated lipocalin – A sensitive marker for urinary tract infection in children

2019 ◽  
Vol 29 (5) ◽  
pp. 340 ◽  
Author(s):  
Indira Agarwal ◽  
Iswarya Jagadesan ◽  
Swasti Chaturvedi ◽  
Arun Jose ◽  
RaniD Sahni ◽  
...  
Keyword(s):  
Urinary Tract Infection ◽  
Urinary Tract ◽  
Tract Infection ◽  
Neutrophil Gelatinase Associated Lipocalin ◽  
Neutrophil Gelatinase ◽  
Sensitive Marker
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