Changes in Anterior Segment Biometry by Laser Iridotomy in Eye With Shallow Anterior Chamber

Childhood glaucoma is a rare disorder that occurs from birth until teenage years caused by an abnormality of aqueous humor pathways. About 50–70% of Peters' anomaly is accompanied by secondary childhood glaucoma. The presence of glaucoma will affect the prognosis. We reported the evaluation and treatment of secondary childhood glaucoma due to Peters’ anomaly. A 5 months-old boy was presented with the complaint of a enlarged left eye since 3 months old. The complaint was accompanied by a watering eye and frequently closed upon light exposure. The left eye looked opaquer than contralateral. Examination under anesthesia showed that the intraocular pressure (IOP) was 35 mmHg in the left eye and the corneal diameter was 14 mm. Other findings were keratopathy, diffuse corneal edema, buphthalmos, shallow anterior chamber, anterior synechiae, and linear slit shaped pupils in the nasal region. Patient was treated with ophthalmic timolol maleate which was later followed by trabeculectomy. After 1 week post-surgery, IOP assessment by palpation suggested the right eye within normal range while the IOP of left eye was higger than normal. Blepharospasm, epiphora, photophobia, bleb on superior, subconjunctiva bleeding, buphthalmos, keratopathy, minimal corneal edema, anterior chamber with shallow image, and posterior synechia were found in left eye anterior segment. In conclusion, trabeculotomy and trabeculectomy are recommended if there is no reduction of IOP observed after receiving timolol maleate therapy. The choice of surgical management is dependent on the feasibility of the protocol.

Download Full-text

Assessment of anterior chamber configuration changes after phacoemulsification with swept-source optical coherence tomography

10.21203/rs.2.9863/v1 ◽

2019 ◽

Author(s):

Man Hu ◽

Qian Zheng ◽

Zhangliang Li ◽

Pingjun Chang ◽

Yun-e Zhao

Keyword(s):

Optical Coherence Tomography ◽

Cataract Surgery ◽

Anterior Chamber ◽

Anterior Segment ◽

Anterior Chamber Depth ◽

Optical Coherence ◽

Swept Source ◽

Narrow Angle ◽

Age Related ◽

Shallow Anterior Chamber

Abstract Background To assess the changes of anterior chamber angle in patients with shallow anterior chamber and normal anterior chamber after phacoemulsification and intraocular lens implantation (IOL) using anterior segment swept-source optical coherence tomography (AS-SS-OCT). Methods This was a prospective case control study; 60 eyes of 60 patients who underwent cataract surgery. Based on anterior chamber depth (ACD) and gonioscopy findings, the eyes were classified into two groups, shallow anterior chamber group (30 eyes) and normal anterior chamber group (30 eyes). AS-SS-OCT was used to measure ACD and angle parameters angle opening distance (AOD), angle recess area (ARA), trabecular iris space area(TISA), and trabecular iris angle (TIA). Serial changes in each group were measured before and 3 months after phacoemulsification and IOL, and the differences between the two groups were compared. Results All angle parameters including ACD, AOD, ARA, TISA, and TIA in both groups at 3 months after cataract surgery were significantly different from the preoperative values (p<0.01). In addition, we found significant differences of all angle parameters between groups of shallow anterior chamber (SAC) and normal anterior chamber (NAC) (All P< 0.05). Besides, the TISA750 in superior quadrant and anterior chamber volume (ACV) were significantly smaller in the group of SAC than those in the group of NAC (P = 0.041 and 0.002, respectively). Conclusions The parameters of anterior chamber increased significantly in both two groups but not increase to the same extent 3 months after phacoemulsification. Iris thickening may also be one of the narrow angle factors,not just age-related lens thickening.

Download Full-text

Quantitative evaluation of changes in anterior segment biometry by peripheral laser iridotomy using newly developed scanning peripheral anterior chamber depth analyser

British Journal of Ophthalmology ◽

10.1136/bjo.2003.036715 ◽

2004 ◽

Vol 88 (8) ◽

pp. 1036-1041 ◽

Cited By ~ 22

Author(s):

K Kashiwagi

Keyword(s):

Anterior Chamber ◽

Quantitative Evaluation ◽

Anterior Segment ◽

Anterior Chamber Depth ◽

Laser Iridotomy

Download Full-text

Detection of Shallow Anterior Chamber Depth from Two-dimensional Anterior Segment Photographs using Deep Learning

10.21203/rs.3.rs-130445/v1 ◽

2021 ◽

Author(s):

Zhuyun Qian ◽

Xiaolin Xie ◽

Jianlong Yang ◽

Hongfei Ye ◽

Zhilei Wang ◽

...

Keyword(s):

Deep Learning ◽

Anterior Chamber ◽

Characteristic Curve ◽

Anterior Segment ◽

Anterior Chamber Depth ◽

Training Dataset ◽

Two Dimensional ◽

High Performing ◽

Testing Dataset ◽

Shallow Anterior Chamber

Abstract Background: The purpose of this study was to implement and evaluate a deep learning (DL) approach for automatically detecting shallow anterior chamber depth (ACD) from two-dimensional (2D) overview anterior segment photographs.Methods: We trained a DL model using a dataset of anterior segment photographs collected from Shanghai Aier Eye Hospital from June 2018 to December 2019. A Pentacam HR system was used to capture a 2D overview eye image and measure the ACD. Shallow ACD was defined as ACD less than 2.4 mm. The DL model was evaluated by a five-fold cross-validation test in a hold-out testing dataset. We also evaluated the DL model by testing it against two glaucoma specialists. The performance of the DL model was calculated by metrics, including accuracy, sensitivity, specificity, and area under the receiver operating characteristic curve (AUC).Results: A total of 4,322 photographs (2,054 shallow AC and 2,268 deep AC images) were assigned to the training dataset, and 482 photographs (229 shallow AC and 253 deep AC images) were held out for internal testing dataset. In detecting shallow ACD in the internal hold-out testing dataset, the DL model achieved an AUC of 0.91 (95% CI, 0.88–0.94) with 82% sensitivity and 84% specificity. In the same testing dataset, the DL model also achieved better performance than the two glaucoma specialists (accuracy of 80% vs. accuracy of 74% and 69%).Conclusions: We proposed a high-performing DL model to automatically detect shallow ACD from overview anterior segment photographs. Our DL model has potential applications in detecting and monitoring shallow ACD in the real world. Trial registration：http://clinicaltrials.gov, NCT04340635, retrospectively registered on 29 March 2020.

Download Full-text

Detection of shallow anterior chamber depth from two-dimensional anterior segment photographs using deep learning

BMC Ophthalmology ◽

10.1186/s12886-021-02104-0 ◽

2021 ◽

Vol 21 (1) ◽

Author(s):

Zhuyun Qian ◽

Xiaoling Xie ◽

Jianlong Yang ◽

Hongfei Ye ◽

Zhilei Wang ◽

...

Keyword(s):

Deep Learning ◽

Anterior Chamber ◽

Characteristic Curve ◽

Anterior Segment ◽

Anterior Chamber Depth ◽

Training Dataset ◽

Two Dimensional ◽

Link Type ◽

Testing Dataset ◽

Shallow Anterior Chamber

Abstract Background The purpose of this study was to implement and evaluate a deep learning (DL) approach for automatically detecting shallow anterior chamber depth (ACD) from two-dimensional (2D) overview anterior segment photographs. Methods We trained a DL model using a dataset of anterior segment photographs collected from Shanghai Aier Eye Hospital from June 2018 to December 2019. A Pentacam HR system was used to capture a 2D overview eye image and measure the ACD. Shallow ACD was defined as ACD less than 2.4 mm. The DL model was evaluated by a five-fold cross-validation test in a hold-out testing dataset. We also evaluated the DL model by testing it against two glaucoma specialists. The performance of the DL model was calculated by metrics, including accuracy, sensitivity, specificity, and area under the receiver operating characteristic curve (AUC). Results A total of 3753 photographs (1720 shallow AC and 2033 deep AC images) were assigned to the training dataset, and 1302 photographs (509 shallow AC and 793 deep AC images) were held out for two internal testing datasets. In detecting shallow ACD in the internal hold-out testing dataset, the DL model achieved an AUC of 0.86 (95% CI, 0.83–0.90) with 80% sensitivity and 79% specificity. In the same testing dataset, the DL model also achieved better performance than the two glaucoma specialists (accuracy of 80% vs. accuracy of 74 and 69%). Conclusions We proposed a high-performing DL model to automatically detect shallow ACD from overview anterior segment photographs. Our DL model has potential applications in detecting and monitoring shallow ACD in the real world. Trial registration http://clinicaltrials.gov, NCT04340635, retrospectively registered on 29 March 2020.

Download Full-text

Application of Anterior Segment Optical Coherence Tomography in Pediatric Ophthalmology

Journal of Ophthalmology ◽

10.1155/2012/313120 ◽

2012 ◽

Vol 2012 ◽

pp. 1-6 ◽

Cited By ~ 10

Author(s):

Ricardo Salles Cauduro ◽

Caroline do Amaral Ferraz ◽

Maira Saad Ávila Morales ◽

Patricia Novita Garcia ◽

Yara Cristina Lopes ◽

...

Keyword(s):

Anterior Chamber ◽

Pediatric Population ◽

Anterior Segment ◽

Anterior Chamber Depth ◽

Case Series ◽

Angle Closure ◽

Optical Coherence ◽

Pediatric Ophthalmology ◽

Retrospective Clinical Study ◽

Shallow Anterior Chamber

Purpose.Application of anterior segment optical coherence (AS-OCT) in pediatric ophthalmology.Methods.Retrospective clinical study case series of 26 eyes of 19 pediatric patients throughout a 21-month period, presenting anterior segment pathologies, were submitted to AS-OCT examination (OCT Visante, 1310 nm, Zeiss), noncontact technique, no sedation requirement.Results.AS-OCT images were obtained from 19 patients (range: 2 months to 12 years). Clinical diagnosis of anterior segment abnormalities included cornea disease (n=7), congenital anterior segment conditions (n=10), ocular trauma (n=1), anterior segment surgeries (n=2), iridocorneal angle abnormalities (n=4), intermediate uveitis (n=2). The most common OCT findings were corneal hyperreflectivity and thickening (n=15), shallow anterior chamber with iris-lens diaphragm anterior displacement (n=4), atypical corneal curvature (n=4), corneal thinning (n=4), peripheral synechiae with angle closure (n=3), increased anterior chamber depth (n=2), and proximal portion of glaucoma drainage tube (n=2).Conclusion.In the present study, noncontact AS-OCT demonstrated to be a feasible technique to evaluate the anterior segment providing anatomic details and useful to clarify diagnosis in the pediatric population.

Download Full-text

The Use of Oculopressor in Shallow Anterior Chamber Cataract Cases

Klinische Monatsblätter für Augenheilkunde ◽

10.1055/s-2008-1057969 ◽

2008 ◽

Vol 225 (S 1) ◽

Author(s):

Z Bíró ◽

T Kerek ◽

K Aranyoss ◽

P Gyaki

Keyword(s):

Anterior Chamber ◽

Shallow Anterior Chamber

Download Full-text

Pediatric Free-floating Anterior Chamber Cyst of the Iris Pigment Epithelium

American Journal of Ophthalmic Clinical Trials ◽

10.25259/ajoct-5-2018 ◽

2018 ◽

Vol 1 ◽

pp. 3

Author(s):

Joshua S Agranat ◽

Yoshihiro Yonekawa

Keyword(s):

Optical Coherence Tomography ◽

Anterior Chamber ◽

Incidental Finding ◽

Pigment Epithelium ◽

Anterior Segment ◽

Ultrasound Biomicroscopy ◽

Optical Coherence ◽

Visual Axis ◽

Associated Malignancy ◽

Anatomic Locations

Iris pigment epithelial (IPE) cysts are a subset of iris cysts that arise from the IPE. They are spontaneously erupting epithelial-lined cavities that are found in various anatomic locations of the iris, including the iris pupillary margin, midzone, periphery, and free floating in the vitreous or anterior chamber. We report the case of an asymptomatic 13-year-old boy with an incidental finding of a dislodged anterior chamber cyst diagnosed on routine examination. Modern multimodal image analysis of the cyst including anterior segment optical coherence tomography and ultrasound biomicroscopy (UBM) was utilized to characterize the microstructural anatomy of the lesion. The patient was managed conservatively without complications. Cysts of the IPE typically do not affect vision or ocular health and can be monitored and observed after ascertaining no associated malignancy. Initial diagnostic investigation can include UBM and anterior segment optical coherence tomography. Intervention should be reserved only for cases where the cyst growth leads to obstruction of the visual axis and/or other secondary complications.

Download Full-text

Changes in anterior segment optical coherence tomography following pars plana vitrectomy without tamponade

International Journal of Retina and Vitreous ◽

10.1186/s40942-021-00285-w ◽

2021 ◽

Vol 7 (1) ◽

Author(s):

Alireza Khodabande ◽

Massood Mohammadi ◽

Hamid Riazi-Esfahani ◽

Shahab Karami ◽

Massood Mirghorbani ◽

...

Keyword(s):

Optical Coherence Tomography ◽

Anterior Chamber ◽

Pars Plana Vitrectomy ◽

Anterior Segment ◽

Anterior Chamber Depth ◽

Optical Coherence ◽

Mean Values ◽

Iop Measurement ◽

Pars Plana ◽

The Mean

Abstract Background To evaluate changes in anterior segment morphology on anterior segment optical coherence tomography (AS-OCT) following pars plana vitrectomy (PPV) without tamponade. Methods Patients who underwent PPV without tamponade for epiretinal membrane were evaluated. Eligible patients underwent intraocular pressure (IOP) measurement and AS-OCT preoperatively as well as 1 month and 6 months post-operatively. Anterior chamber width (ACW), anterior chamber depth (ACD), trabecular iris angle (TIA), angle opening distance at 500 and 750 µm (AOD), and trabecular iris space area at 500 and 750 µm (TISA) at four quadrants were recorded and analyzed. Additionally, the mean values of TIA (MTIA), AOD (MAOD), and TISA (MTISA) for each eye (mean of four quadrants) were analyzed. Results 23 patients completed the study. The mean age of participants was 56.4 ± 3.6 years of age and 13/23 (56%) were female. Mean IOP of patients was 18.1 ± 1.1, 18.3 ± 1.1, and 18.1 ± 1.2 preoperatively,1 month post-operatively, and 6 months post-operatively, respectively. (p = 0.83). No difference was detected post-operatively in measurements of ACW, ACD, MTIA, MAOD500, MAOD750, MTISA500, and MTISA750. Conclusion Pars plana vitrectomy without tamponade was not associated with changes in anterior chamber morphology.

Download Full-text