scholarly journals Choroidal Thickness in Thyroid-associated Ophthalmopathy between Normal Tension Glaucoma Using Optical Coherence Tomography

2017 ◽  
Vol 58 (8) ◽  
pp. 960
Author(s):  
Bo Young Lee ◽  
Tae Yoon La ◽  
Jin A Choi
Keyword(s):  
Optical Coherence Tomography ◽  
Choroidal Thickness ◽  
Normal Tension Glaucoma ◽  
Optical Coherence ◽  
Thyroid Associated Ophthalmopathy

scholarly journals Evaluation of retinal and choroidal variations in thyroid-associated ophthalmopathy using optical coherence tomography angiography

2020 ◽  
Vol 20 (1) ◽  
Author(s):  
Lanchu Yu ◽  
Qin Jiao ◽  
Yu Cheng ◽  
Yanji Zhu ◽  
Zhongjing Lin ◽  
...  
Keyword(s):  
Optical Coherence Tomography ◽  
Choroidal Thickness ◽  
Optical Coherence Tomography Angiography ◽  
The Other ◽  
Vascular Density ◽  
Retinal Vessels ◽  
Optical Coherence ◽  
Rnfl Thickness ◽  
Thyroid Associated Ophthalmopathy ◽  
Perfusion Density

Abstract Background To investigate the difference in retinal nerve fiber layer (RNFL) thickness, choroidal thickness (CT) and superficial retinal vessels between thyroid-associated ophthalmopathy (TAO) patients and healthy controls. To identify the potential influencing factors for these parameters and evaluate their diagnostic abilities in TAO. Methods Twenty active TAO patients, 33 inactive TAO patients and 29 healthy participants were enrolled. TAO patients were divided according to the clinical activity score (CAS). RNFL thickness and CT were measured by HD-OCT, while foveal avascular zone (FAZ), vascular density and perfusion density were measured by optical coherence tomography angiography (OCTA). SPSS software was used for statistical analysis. Results Active TAO patients had thinner RNFL thickness than the other two groups (P < 0.001, P < 0.001). Both active and inactive TAO patients had significantly higher CT in the macular region (all P < 0.05). The FAZ area in the active TAO group was significantly larger than the other two groups (P = 0.045, P = 0.001). The inactive TAO group had significantly higher vascular density than the other two groups (all P < 0.05). With regard to the perfusion density, significant differences were observed in the temporal and inferior areas (P = 0.045, P = 0.001), as well as the average values (P = 0.032). The FAZ area was positively correlated with intraocular pressure (r = 0.274, P = 0.013), while it was negatively correlated with axial length (r = − 0.344, P = 0.002). The vascular density and perfusion density were not significantly correlated with different clinical variables (all P > 0.05). The AUC analysis indicated these parameters also exhibited a significant discriminatory power in TAO diagnosis. Conclusions TAO patients had significant variations in RNFL thickness, choroidal thickness, FAZ area and superficial retinal vessels. These parameters appeared to be potential adjuncts in the evaluation of TAO patients.

scholarly journals Evaluation of retinal and choroidal variations in thyroid-associated ophthalmopathy using optical coherence tomography angiography

2020 ◽  
Author(s):  
Lanchu Yu ◽  
Qin Jiao ◽  
Yu Cheng ◽  
Yanji Zhu ◽  
Zhongjing Lin ◽  
...  
Keyword(s):  
Optical Coherence Tomography ◽  
Choroidal Thickness ◽  
Optical Coherence Tomography Angiography ◽  
The Other ◽  
Vascular Density ◽  
Retinal Vessels ◽  
Optical Coherence ◽  
Rnfl Thickness ◽  
Thyroid Associated Ophthalmopathy ◽  
Perfusion Density

Abstract Background To investigate the difference in retinal nerve fiber layer (RNFL) thickness, choroidal thickness (CT) and superficial retinal vessels between thyroid-associated ophthalmopathy (TAO) patients and healthy controls. To identify the potential influencing factors for these parameters and evaluate their diagnostic abilities in TAO. Methods 20 active TAO patients, 33 inactive TAO patients and 29 healthy participants were enrolled. TAO patients were divided according to the clinical activity score (CAS). RNFL thickness and CT were measured by HD-OCT, while foveal avascular zone (FAZ), vascular density and perfusion density were measured by optical coherence tomography angiography (OCTA). SPSS software was used for statistical analysis. Results Active TAO patients had thinner RNFL thickness than the other two groups (P < 0.001, P < 0.001). Both active and inactive TAO patients had significantly higher CT than controls in the macular region (all P < 0.05). The mean area of FAZ in the active TAO group was significantly larger than the other two groups (P = 0.045, P = 0.001). The inactive TAO group had significantly higher vessel length density than the other two groups (all P < 0.05). With regard to the perfusion density, significant differences were observed in the temporal and inferior areas (P = 0.045, P = 0.001), as well as the average values (P = 0.032). The FAZ area, vascular density and perfusion density in active and inactive TAO patients were not significantly correlated with different clinical variables (all P > 0.05). The AUC analysis indicated these parameters also exhibited a significant discriminatory power in TAO diagnosis. Conclusions TAO patients had significant variations in RNFL thickness, choroidal thickness, FAZ area and superficial retinal vessels. These parameters appeared to be potential adjuncts in TAO diagnosis.

scholarly journals Evaluation of retinal and choroidal variations in thyroid-associated ophthalmopathy using optical coherence tomography angiography

2020 ◽  
Author(s):  
Lanchu Yu ◽  
Qin Jiao ◽  
Yu Cheng ◽  
Yanji Zhu ◽  
Zhongjing Lin ◽  
...  
Keyword(s):  
Optical Coherence Tomography ◽  
Choroidal Thickness ◽  
Optical Coherence Tomography Angiography ◽  
The Other ◽  
Vascular Density ◽  
Retinal Vessels ◽  
Optical Coherence ◽  
Rnfl Thickness ◽  
Thyroid Associated Ophthalmopathy ◽  
Perfusion Density

Abstract Background: To investigate the difference in retinal nerve fiber layer (RNFL) thickness, choroidal thickness (CT) and superficial retinal vessels between thyroid-associated ophthalmopathy (TAO) patients and healthy controls. To identify the potential influencing factors for these parameters and evaluate their diagnostic abilities in TAO.Methods: 20 active TAO patients, 33 inactive TAO patients and 29 healthy participants were enrolled. TAO patients were divided according to the clinical activity score (CAS). RNFL thickness and CT were measured by HD-OCT, while foveal avascular zone (FAZ), vascular density and perfusion density were measured by optical coherence tomography angiography (OCTA). SPSS software was used for statistical analysis.Results: Active TAO patients had thinner RNFL thickness than the other two groups (P<0.001, P<0.001). Both active and inactive TAO patients had significantly higher CT in the macular region (all P<0.05). The FAZ area in the active TAO group was significantly larger than the other two groups (P=0.045, P=0.001). The inactive TAO group had significantly higher vascular density than the other two groups (all P<0.05). With regard to the perfusion density, significant differences were observed in the temporal and inferior areas (P=0.045, P=0.001), as well as the average values (P=0.032). The FAZ area was positively correlated with intraocular pressure (r=0.274, P=0.013), while it was negatively correlated with axial length (r=-0.344, P=0.002). The vascular density and perfusion density were not significantly correlated with different clinical variables (all P>0.05). The AUC analysis indicated these parameters also exhibited a significant discriminatory power in TAO diagnosis.Conclusions: TAO patients had significant variations in RNFL thickness, choroidal thickness, FAZ area and superficial retinal vessels. These parameters appeared to be potential adjuncts in the evaluation of TAO patients.

scholarly journals Evaluation of retinal and choroidal variations in thyroid-associated ophthalmopathy using optical coherence tomography angiography

2020 ◽  
Author(s):  
Lanchu Yu ◽  
Qin Jiao ◽  
Yu Cheng ◽  
Yanji Zhu ◽  
Zhongjing Lin ◽  
...  
Keyword(s):  
Optical Coherence Tomography ◽  
Choroidal Thickness ◽  
Optical Coherence Tomography Angiography ◽  
The Other ◽  
Vascular Density ◽  
Retinal Vessels ◽  
Optical Coherence ◽  
Rnfl Thickness ◽  
Thyroid Associated Ophthalmopathy ◽  
Perfusion Density

Abstract Background: To investigate the difference in retinal nerve fiber layer (RNFL) thickness, choroidal thickness (CT) and superficial retinal vessels between thyroid-associated ophthalmopathy (TAO) patients and healthy controls. To identify the potential influencing factors for these parameters and evaluate their diagnostic abilities in TAO.Methods: 20 active TAO patients, 33 inactive TAO patients and 29 healthy participants were enrolled. TAO patients were divided according to the clinical activity score (CAS). RNFL thickness and CT were measured by HD-OCT, while foveal avascular zone (FAZ), vascular density and perfusion density were measured by optical coherence tomography angiography (OCTA). SPSS software was used for statistical analysis.Results: Active TAO patients had thinner RNFL thickness than the other two groups (P<0.001, P<0.001). Both active and inactive TAO patients had significantly higher CT in the macular region (all P<0.05). The FAZ area in the active TAO group was significantly larger than the other two groups (P=0.045, P=0.001). The inactive TAO group had significantly higher vascular density than the other two groups (all P<0.05). With regard to the perfusion density, significant differences were observed in the temporal and inferior areas (P=0.045, P=0.001), as well as the average values (P=0.032). The FAZ area was positively correlated with intraocular pressure (r=0.274, P=0.013), while it was negatively correlated with axial length (r=-0.344, P=0.002). The vascular density and perfusion density were not significantly correlated with different clinical variables (all P>0.05). The AUC analysis indicated these parameters also exhibited a significant discriminatory power in TAO diagnosis.Conclusions: TAO patients had significant variations in RNFL thickness, choroidal thickness, FAZ area and superficial retinal vessels. These parameters appeared to be potential adjuncts in the evaluation of TAO patients.

scholarly journals Automatic Segmentation of Choroid Layer Using Deep Learning on Spectral Domain Optical Coherence Tomography

2021 ◽  
Vol 11 (12) ◽  
pp. 5488
Author(s):  
Wei Ping Hsia ◽  
Siu Lun Tse ◽  
Chia Jen Chang ◽  
Yu Len Huang
Keyword(s):  
Optical Coherence Tomography ◽  
Deep Learning ◽  
Choroidal Thickness ◽  
Automatic Segmentation ◽  
Average Error ◽  
Good Prediction ◽  
Optical Coherence ◽  
Learning Method ◽  
Subfoveal Choroidal Thickness ◽  
Fully Connected

The purpose of this article is to evaluate the accuracy of the optical coherence tomography (OCT) measurement of choroidal thickness in healthy eyes using a deep-learning method with the Mask R-CNN model. Thirty EDI-OCT of thirty patients were enrolled. A mask region-based convolutional neural network (Mask R-CNN) model composed of deep residual network (ResNet) and feature pyramid networks (FPNs) with standard convolution and fully connected heads for mask and box prediction, respectively, was used to automatically depict the choroid layer. The average choroidal thickness and subfoveal choroidal thickness were measured. The results of this study showed that ResNet 50 layers deep (R50) model and ResNet 101 layers deep (R101). R101 U R50 (OR model) demonstrated the best accuracy with an average error of 4.85 pixels and 4.86 pixels, respectively. The R101 ∩ R50 (AND model) took the least time with an average execution time of 4.6 s. Mask-RCNN models showed a good prediction rate of choroidal layer with accuracy rates of 90% and 89.9% for average choroidal thickness and average subfoveal choroidal thickness, respectively. In conclusion, the deep-learning method using the Mask-RCNN model provides a faster and accurate measurement of choroidal thickness. Comparing with manual delineation, it provides better effectiveness, which is feasible for clinical application and larger scale of research on choroid.

scholarly journals The role of pattern electroretinograms and optical coherence tomography angiography in the diagnosis of normal-tension glaucoma

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Sang Yeop Lee ◽  
Nak-Hoon Son ◽  
Hyoung Won Bae ◽  
Gong Je Seong ◽  
Chan Yun Kim
Keyword(s):  
Optical Coherence Tomography ◽  
Optical Coherence Tomography Angiography ◽  
Early Stage ◽  
Pattern Electroretinogram ◽  
Normal Tension Glaucoma ◽  
Optical Coherence ◽  
Early Glaucoma ◽  
Normal Individuals ◽  
Auc Value ◽  
Glaucoma Group

AbstractIn this study, we investigated the correlation between pattern electroretinogram (PERG) and optical coherence tomography angiography (OCTA) parameters for diagnosis in patients with normal-tension glaucoma (NTG). Forty-nine normal individuals (49 eyes) and 60 patients with NTG (60 eyes) were enrolled. OCTA and PERG parameters, such as macular vessel density (VD) and the amplitude of N35–P50 and P50–N95, were measured. Correlation analyses were performed between the parameters, and the area under the curve (AUC) was used to identify their diagnostic ability for NTG. Macular VD and the amplitude of N35–P50 and P50–N95 showed significant differences between the normal individuals and patients with NTG. Correlation between P50 and N95 amplitude and macular VD was significant in the normal and early glaucoma groups. Macular VD showed a higher AUC value (0.730) than that of P50–N95 amplitude (0.645) in the early glaucoma group. In the moderate to severe glaucoma group, the AUC value of the amplitude of P50–N95 (0.907) was higher than that of macular VD (0.876). The results indicate that PERG and OCTA parameters may identify glaucoma in its early stage, based on the severity of glaucomatous damage in patients with NTG.

scholarly journals Geographic mapping of choroidal thickness in myopic eyes using 1050-nm spectral domain optical coherence tomography

2015 ◽  
Vol 08 (04) ◽  
pp. 1550012 ◽  
Author(s):  
Qinqin Zhang ◽  
Maureen Neitz ◽  
Jay Neitz ◽  
Ruikang K. Wang
Keyword(s):  
Optical Coherence Tomography ◽  
High Myopia ◽  
Choroidal Thickness ◽  
Retinal Pigment ◽  
Reduction Rate ◽  
Radial Distance ◽  
Spectral Domain ◽  
Temporal Region ◽  
Optical Coherence ◽  
The Mean

Purpose: To provide a geographical map of choroidal thickness (CT) around the macular region among subjects with low, moderate and high myopia. Methods: 20 myopic subjects (n = 40 eyes) without other identified pathologies participated in this study: 20 eyes of ≤ 3 diopters (D) (low myopic), 10 eyes between -3 and -6D (moderate myopic), and 10 eyes of ≥ 6D (high myopic). The mean age of subjects was 30.2 years (± 7.6 years; range, 24 to 46 years). A 1050 nm spectral-domain optical coherence tomography (SD-OCT) system, operating at 120 kHz imaging rate, was used in this study to simultaneously capture 3D anatomical images of the choroid and measure intraocular length (IOL) in the subject. The 3D OCT images of the choroid were segmented into superior, inferior, nasal and temporal quadrants, from which the CT was measured, representing radial distance between the outer retinal pigment epithelium (RPE) layer and inner scleral border. Measurements were made within concentric regions centered at fovea centralis, extended to 5 mm away from fovea at 1 mm intervals in the nasal and temporal directions. The measured IOL was the distance from the anterior cornea surface to the RPE in alignment along the optical axis of the eye. Statistical analysis was performed to evaluate CT at each geographic region and observe the relationship between CT and the degree of myopia. Results: For low myopic eyes, the IOL was measured at 24.619 ± 0.016 mm. The CT (273.85 ± 49.01 μm) was greatest under fovea as is in the case of healthy eyes. Peripheral to the fovea, the mean CT decreased rapidly along the nasal direction, reaching a minimum of 180.65 ± 58.25μm at 5 mm away from the fovea. There was less of a change in thickness from the fovea in the temporal direction reaching a minimum of 234.25 ± 42.27 μm. In contrast to the low myopic eyes, for moderate and high myopic eyes, CTs were thickest in temporal region (where CT = 194.94 ± 27.28 and 163 ± 34.89 μm, respectively). Like the low myopic eyes, moderate and high myopic eyes had thinnest CTs in the nasal region (where CT = 100.84 ± 16.75 and 86.64 ± 42.6μm, respectively). High myopic eyes had the longest mean IOL (25.983 ± 0.021mm), while the IOL of moderate myopia was 25.413 ± 0.022 mm (**p < 0.001). The CT reduction rate was calculated at 31.28 μm/D (diopter) from low to moderate myopia, whilst it is 13.49 μm/D from moderate to high myopia. The similar tendency was found for the IOL reduction rate in our study: 0.265 mm/D from low to moderate myopia, and 0.137 mm/D from moderate to high myopia. Conclusion: The CT decreases and the IOL increases gradually with the increase of myopic condition. The current results support the theory that choroidal abnormality may play an important role in the pathogenesis of myopic degeneration.

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