A Case Report of 41-Year-Old Female with Fibrous Dysplasia Combined with Ethmoid Mucocele

Fibrous dysplasia (FD) is a non-malignant progressive condition, which replaces normal bone and marrow with fibrous tissue and woven bone. Sinus mucocele is a cystic, expansile, and destructive lesion that occurs as a result of obstruction of the sinus ostium secondary to inflammation, trauma, anatomical variation, previous sinus surgery, tumor or FD. Among them, FD combined with mucocele has been rarely reported. Here we report the first case of FD combined with ethmoid mucocele. The patient underwent endoscopic debulking of FD and marsupialization of mucocele. The mucocele was successfully marsupialized, and the patient’s symptoms were completely resolved. We propose a new hypothesis that nasal mucosa invaginates into FD and forms a mucocele. For the treatment of ethmoid FD combined with mucocele, we recommend an endoscopic transnasal approach for debulking and marsupialization.

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Fibrous Dysplasia With Degenerative Atypia: A Benign Lesion Potentially Mistaken for Sarcoma

Archives of Pathology & Laboratory Medicine ◽

10.5858/2004-128-794-fdwdaa ◽

2004 ◽

Vol 128 (7) ◽

pp. 794-796 ◽

Cited By ~ 1

Author(s):

Franco Bertoni ◽

Luis Fernando Arias ◽

Marco Alberghini ◽

Patrizia Bacchini

Keyword(s):

Fibrous Dysplasia ◽

Benign Lesion ◽

Osteolytic Lesion ◽

Fibrous Tissue ◽

Woven Bone ◽

Atypical Cells ◽

Nuclear Changes ◽

Mitotic Figures ◽

Bone Trabeculae ◽

The Right

Abstract Fibrous dysplasia is a benign disorder of bone in which proliferating fibrous tissue replaces the bony spongiosa. Cytologic atypia is generally not considered a feature of this proliferating tissue. We present a case of fibrous dysplasia with marked atypical nuclear changes consistent with degenerative or regressive changes. A 42-year-old man presented with an osteolytic lesion of the right iliac bone. Histologic study demonstrated a fibro-osseous lesion with woven bone trabeculae and bland-looking fibrous tissue. Several areas showed atypical cells with enlarged pleomorphic nuclei and bizarre features. There was no change in the nuclear-cytoplasmic ratio nor were mitotic figures identified. The differential diagnosis is discussed. When radiographic and other histologic findings suggest fibrous dysplasia, the atypical nuclear changes should not, by themselves, alter the diagnosis.

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Frontal bone fibrous dysplasia in a 6-months-old boy: A distinctive entity

La Pediatria Medica e Chirurgica ◽

10.4081/pmc.2021.225 ◽

2021 ◽

Vol 43 (1) ◽

Author(s):

Kleanthis Anastasiadis ◽

Vassilis Lambropoulos ◽

Kalliopi Tsoleka ◽

Chrysostomos Kepertis ◽

Vassilis Mouravas ◽

...

Keyword(s):

Fibrous Dysplasia ◽

Stromal Cells ◽

Fibrous Tissue ◽

Activating Mutations ◽

Normal Bone ◽

Woven Bone ◽

Gnas Gene ◽

Cosmetic Effect ◽

Differentiation And Proliferation ◽

Malignant Condition

Fibrous Dysplasia (FD) is a non-malignant condition caused by post-zygotic, activating mutations of the GNAS gene that results in inhibition of the differentiation and proliferation of bone-forming stromal cells and leads to the replacement of normal bone and marrow by fibrous tissue and woven bone. The clinical behavior and progression of FD is variable. The management of this condition is difficult and in every case is strictly individualized. We report a case of frontal fibrous dysplasia in a 6month’s old boy who underwent a successfully resection of the lesion with an excellent cosmetic effect.

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Cholesterol Granuloma as a Late Complication of Endoscopic Sinus Surgery

American Journal of Surgical Case Reports ◽

10.31487/j.ajscr.2020.04.04 ◽

2020 ◽

pp. 1-4

Author(s):

Maria Riga ◽

G Danielides ◽

S Naxakis ◽

S Lygeros ◽

D Bantouna ◽

...

Keyword(s):

Endoscopic Sinus Surgery ◽

Sphenoid Sinus ◽

Late Complication ◽

Fibrous Tissue ◽

Sinus Surgery ◽

Cholesterol Granuloma ◽

Tissue Formation ◽

Convergence Insufficiency ◽

First Case ◽

Successful Removal

Introduction: To date there are five reports referring to cholesterol granuloma of the sphenoid sinus. This is the first case where cholesterol granuloma is presented as a late complication after successful removal of a mucocele through functional endoscopic sinus surgery (FESS) and associated with convergence insufficiency. Case Report: A 67-year-old carpenter presented with binocular diplopia and frontal headache. A mucocele of the left sphenoid sinus was removed endoscopically leading to the resolution of his symptoms. Eight months later he presented with similar symptoms and findings. Following a revision FESS, cholesterol granuloma was diagnosed. Discussion: Haemorrhage within the sphenoid sinus, obstruction in the sinus ostium and fibrous tissue formation may explain the postoperative formation of cholesterol granuloma. Convergence insufficiency could be attributed to mechanical failure or denervation of eye muscles. Conclusion: Cholesterol granuloma should be included in the differential diagnosis, when recurrence of a sphenoid sinus mucocele is suspected.

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Expanded Endoscopic Transnasal Approach to the Chordoid Glioma of the Third Ventricle : The First Case Ever Reported

Journal of Korean Neurosurgical Society ◽

10.3340/jkns.2016.59.6.643 ◽

2016 ◽

Vol 59 (6) ◽

pp. 643 ◽

Cited By ~ 3

Author(s):

Mehdi Zeinalizadeh ◽

Seyed Mousa Sadrehosseini ◽

Keyvan Tayebi Meybodi ◽

Ali Heidari Sharifabadi

Keyword(s):

Third Ventricle ◽

Transnasal Approach ◽

The Third ◽

First Case ◽

Endoscopic Transnasal Approach ◽

Chordoid Glioma

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External auditory canal stenosis due to isolated fibrous dysplasia of temporal bone: a case report

International Journal of Otorhinolaryngology and Head and Neck Surgery ◽

10.18203/issn.2454-5929.ijohns20195715 ◽

2019 ◽

Vol 6 (1) ◽

pp. 204

Author(s):

Manju Silu ◽

Gaurav Gupta

Keyword(s):

Fibrous Dysplasia ◽

Temporal Bone ◽

External Auditory Canal ◽

Fibrous Tissue ◽

Benign Disease ◽

High Grade ◽

Rare Entity ◽

Canal Stenosis ◽

Woven Bone

<p class="abstract">Benign disease of bone marrow in which marrow is reorganize into fibrous tissue and immature woven bone, is known as fibrous dysplasia. Involvement of temporal bone is rare and can be isolated or in monostotic or polystotic form with various otologic manifestations. We are here reporting a case of fibrous dysplasia of the unilateral temporal bone who presented with hearing loss and stenosis of the external auditory canal. External auditory canal stenosis due to fibrous dysplasia was managed with canalplasty and patient was free of recurrence till last follow up. Fibrous dysplasia of isolated temporal bone is a rare entity which requires high grade of suspicion in a patient who presents with unusual bony swellings in the ear. Its management usually includes resection of the most affected part of temporal bone in order to achieve auditory canal patency and restoration of hearing. After surgery, a close follow up is warranted due to its propensity of recurrence.</p>

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