scholarly journals MIB-1 Labeling Index is Very Important Proliferative Factor for Lymphangioma

2021 ◽  
Vol 5 (3) ◽  
Author(s):  
Yoko Kishi ◽  
Kentaro Matsuoka
Keyword(s):  
Endothelial Cells ◽  
Rapid Growth ◽  
High Potential ◽  
Labeling Index ◽  
Intralesional Injection ◽  
Fast Growing ◽  
Immunological Technique ◽  
Mib 1

Our concept for the treatment of lymphangioma is simple resection if it is small and adjacent to the surface of the skin and intralesional injection of OK- 32 if it is big. Resection of the mass is performed if its size has reduced after observation, but persisted. The rapid growth of the lymphangioma has been considered to be due to inflammation and invasion of the vessels, but their relationship remains unclear. Our hypothesis is that the Mib1-labeling index of endothelial cells of fast-growing lymphangioma is larger than that of non-proliferating lymphangioma. Mib-1 labeling index shows their ability of proliferation. In our study, we could show the high potential cells of lymphangioma had high MIB1 index using the immunological technique of the pathology.

scholarly journals Clinical outcome and molecular characterization of pediatric glioblastoma treated with postoperative radiotherapy with concurrent and adjuvant temozolomide: a single institutional study of 66 children

2015 ◽  
Vol 3 (1) ◽  
pp. 39-47 ◽  
Author(s):  
Rakesh Jalali ◽  
Anupam Rishi ◽  
Jayant S. Goda ◽  
Epari Sridhar ◽  
Mamta Gurav ◽  
...  
Keyword(s):  
Overall Survival ◽  
Clinical Outcome ◽  
Labeling Index ◽  
Molecular Profile ◽  
Mgmt Methylation ◽  
P53 Overexpression ◽  
P53 Expression ◽  
Egfr Amplification ◽  
Adjuvant Temozolomide ◽  
Mib 1

Abstract Background Glioblastoma (GBM) in children is rare. Pediatric GBM have a distinct molecular profile as compared to adult GBM. There are relatively few studies of pediatric GBMs and no standard of care on adjuvant therapy. We aimed to evaluate the clinical outcome and molecular profile of pediatric GBM. Methods and Materials Between 2004 and 2013, 66 consecutive children with histologically proven GBM were identified from our database. The majority of the children underwent maximal safe resection followed by focal radiotherapy with concurrent and adjuvant temozolomide. Immunohistochemical staining was performed for p53, MIB-1 labeling index, MGMT overexpression, and EGFR amplification and isocitrate dehydrogenase (IDH1) R132H point mutation. Survival and impact of possible prognostic factors on outcomes were analyzed. Result Median survival was 15 months. The overall survival rate at 1 year was 62%, at 2 years was 30%, and at 3 years was 27%. Patients with thalamic tumors (P < .001), incompletely resected tumors (P < .00001), and tumors with MIB-1 labeling index >25% (P < .002) had poor overall survival rates. p53 was overexpressed in 74% of patients, MGMT promoter methylation was seen in 37% of patients, IDH1 mutation was seen in 4% of patients, and no patients had EGFR amplification. MGMT methylation and p53 overexpression did not impact survival. Conclusions Clinical outcome of pediatric GBM is similar to that reported for adult GBM. The frequency of p53 overexpression is higher than in adult GBM, while MGMT methylation, IDH1 mutations and EGFR amplification is lower than in adult GBM. MGMT methylation and p53 expression status do not have any prognostic significance.

Cities in the Gulf

2018 ◽  
pp. 1230-1254
Author(s):  
Djamel Boussaa
Keyword(s):  
Urban Environment ◽  
Rapid Growth ◽  
Urban Life ◽  
Cultural Identities ◽  
Fast Growing ◽  
The 1950S ◽  
Historic City ◽  
Ways Of Being

In fast growing cities, such as Dubai, Jeddah and Doha the issue of identity and its implications are increasingly complex and multi-dimensional. Traditionally, people were able to maintain a strong identity in their urban environment because everything was locally influenced, created and managed. In dealing with the question of identity in the present Gulf city, several important concepts are raised; impact of rapid growth and urbanization on the resilient historic centers is one such important issue. This chapter raises and discusses the following question “Will the historic city, the heart of urban life, survive and maintain its place in the emerging global Gulf cities of today and tomorrow?” This study will focus on the three old centers of Dubai, Jeddah and Doha with the aim to explore ways of being undertaken to rediscover their vanishing cultural identities in the mainstream of rapid growth and urbanization that happened since the discovery of oil in the 1950s.

Cities in the Gulf

2016 ◽  
pp. 166-191 ◽  
Author(s):  
Djamel Boussaa
Keyword(s):  
Urban Environment ◽  
Rapid Growth ◽  
Urban Life ◽  
Cultural Identities ◽  
Fast Growing ◽  
The 1950S ◽  
Historic City ◽  
Ways Of Being

In fast growing cities, such as Dubai, Jeddah and Doha the issue of identity and its implications are increasingly complex and multi-dimensional. Traditionally, people were able to maintain a strong identity in their urban environment because everything was locally influenced, created and managed. In dealing with the question of identity in the present Gulf city, several important concepts are raised; impact of rapid growth and urbanization on the resilient historic centers is one such important issue. This chapter raises and discusses the following question “Will the historic city, the heart of urban life, survive and maintain its place in the emerging global Gulf cities of today and tomorrow?” This study will focus on the three old centers of Dubai, Jeddah and Doha with the aim to explore ways of being undertaken to rediscover their vanishing cultural identities in the mainstream of rapid growth and urbanization that happened since the discovery of oil in the 1950s.

Breast Cancer in a Patient under Levodopa Treatment

1978 ◽  
Vol 64 (3) ◽  
pp. 267-271 ◽  
Author(s):  
Federico Bozzetti ◽  
Emanuele Galante ◽  
Aurora Costa
Keyword(s):  
Breast Cancer ◽  
Case History ◽  
Rapid Growth ◽  
Mammary Cancer ◽  
Doubling Time ◽  
Labeling Index ◽  
Continuous Treatment ◽  
Promoter Effect ◽  
History Of ◽  
Prolactin Inhibition

A case history of a patient who developed mammary cancer (T1N1bM0) after 5 ½ years of continuous treatment with Levodopa for Parkinson's disease is presented. The prolactin inhibition by the Levodopa was verified, and the clinical and mammographic growth, the doubling time, and the labeling index of the tumor were determined. The results were not significantly different than those obtained from patients with breast cancer not under treatment with Levodopa. The rapid growth and evolution of this tumor suggests that prolactin does not have an inducer or promoter effect in mammary cancer.

Clinicopathological features, MIB-1 labeling index and apoptotic index in recurrent astrocytic tumors

2001 ◽  
Vol 7 (4) ◽  
pp. 267-278 ◽  
Author(s):  
Angela Mercy Ralte ◽  
Mehar Chand Sharma ◽  
Asis Kumar Karak ◽  
Veer Singh Mehta ◽  
Chitra Sarkar
Keyword(s):  
Apoptotic Index ◽  
Clinicopathological Features ◽  
Labeling Index ◽  
Astrocytic Tumors ◽  
Mib 1

scholarly journals Estimation of proliferative potentiality of central neurocytoma: correlational analysis of minimum ADC and maximum SUV with MIB-1 labeling index

2015 ◽  
Vol 56 (1) ◽  
pp. 114-120 ◽  
Author(s):  
Ryo Sakamoto ◽  
Tomohisa Okada ◽  
Mitsunori Kanagaki ◽  
Akira Yamamoto ◽  
Yasutaka Fushimi ◽  
...  
Keyword(s):  
Correlational Analysis ◽  
Central Neurocytoma ◽  
Labeling Index ◽  
Mib 1

The resistance of Pinus radiata to infection by Macrophoma pinea

1970 ◽  
Vol 18 (1) ◽  
pp. 55 ◽  
Author(s):  
GC Marks ◽  
G Minko
Keyword(s):  
Pinus Radiata ◽  
Rapid Growth ◽  
Biochemical Changes ◽  
Fast Growing ◽  
Entry Points ◽  
Different Ages ◽  
Mechanical Barrier ◽  
New Entry

The resistance of wounds made on Pinus radiata to infection by Macrophoma pinea was examined experimentally in the greenhouse and field. A study was made of the anatomy of the epidermal tissues of the leader and stem, of injuries of different ages, and of the recovery stages after inoculation. There were many structural similarities between bark and wound periderm. Both provided mechanical barriers to infection by M. pinea. Wound periderm began to form 3-9 days after injury, and the mechanical barriers appeared after about 18 days. Wounds became resistant to infection after about 3-9 days, which suggests that this resistance was associated with biochemical changes in the uninjured cells lining the wound rather than with the appearance of the mechanical barrier. Superficial injuries occluded rapidly. Wounds on fast-growing trees, however, healed slowly when the cambium was injured; the rapid growth of the xylem continually lifted the callus that was formed over the injury, providing new entry points for M. pinea. This may explain the greater incidence of malformations on very productive sites.

Residual nonfunctioning pituitary adenomas: prognostic value of MIB-1 labeling index for tumor progression

2009 ◽  
Vol 111 (3) ◽  
pp. 563-571 ◽  
Author(s):  
Georg Widhalm ◽  
Stefan Wolfsberger ◽  
Matthias Preusser ◽  
Ingeborg Fischer ◽  
Adelheid Woehrer ◽  
...  
Keyword(s):  
Tumor Progression ◽  
Pituitary Adenomas ◽  
Residual Tumor ◽  
Labeling Index ◽  
Ki 67 ◽  
Nonfunctioning Pituitary Adenomas ◽  
Time Period ◽  
Tumor Group ◽  
Significant Difference ◽  
Mib 1

Object In residual nonfunctioning pituitary adenomas, reliable prognostic parameters indicating probability of tumor progression are needed. The Ki 67 expression/MIB-1 labeling index (LI) is considered to be a promising candidate factor. The aim in the present study was to analyze the clinical usefulness of MIB-1 LI for prognosis of tumor progression. Methods The authors studied a cohort of 92 patients with nonfunctioning pituitary adenomas. Based on sequential postoperative MR images, patients were classified as tumor free (51 patients) or as harboring residual tumor (41 individuals). The residual tumor group was further subdivided in groups with stable residual tumors (14 patients) or progressive residual tumors (27 patients). The MIB-1 LI was assessed in tumor specimens obtained in all patients, and statistical comparisons of MIB-1 LI of the various subgroups were performed. Results . The authors found no significant difference of MIB-1 LI in the residual tumor group compared with the tumor-free group. However, MIB-1 LI was significantly higher in the progressive residual tumor group, compared with the stable residual tumor group. Additionally, the time period to second surgery was significantly shorter in residual adenomas showing an MIB-1 LI > 3%. Conclusions The data indicate that MIB-1 LI in nonfunctioning pituitary adenomas is a clinically useful prognostic parameter indicating probability of progression of postoperative tumor remnants. The MIB-1 LI may be helpful in decisions of postoperative disease management (for example, frequency of radiographic intervals, planning for reoperation, radiotherapy, and/or radiosurgery).

Sign in / Sign up

Export Citation Format

Share Document