scholarly journals Molecular Identification of Schizophyllum commune as a Cause of Allergic Fungal Sinusitis

2012 ◽  
Vol 32 (5) ◽  
pp. 375-779 ◽  
Author(s):  
Eun Jeong Won ◽  
Jong Hee Shin ◽  
Sang Chul Lim ◽  
Myung Geun Shin ◽  
Soon Pal Suh ◽  
...  
1995 ◽  
Vol 9 (3) ◽  
pp. 149-154 ◽  
Author(s):  
Brian E. Emery ◽  
Arnold D. Oberle ◽  
Fleurette Abreo ◽  
Terry A. Day ◽  
Fred J. Stucker

Chronic sinusitis is now considered the most common chronic disease seen in this country.1 The infections are commonly polymicrobial and include aerobes and anaerobes.2 Fungal sinusitis accounts for up to 10% of cases of chronic sinusitis, and the disease ranges from allergic fungal sinusitis through fungus balls to invasive fungal sinus disease.3,4 We report the case of a 19-year-old black female with nasal obstruction, clear rhinorrhea, and nasal polyps. She underwent endoscopic sinus surgery after medical management failed to eradicate her symptoms. Cultures from her paranasal sinuses grew S. commune, a mushroom, a member of the Basidiomycetes. There have been four prior reports of S. commune sinusitis described in the literature. Presented is a review of the literature, a description of the histologic, mycologic, and radiologic findings and suggested treatment. The magnetic resonance imaging (MRI) findings are presented here for the first time.


1996 ◽  
Vol 32 (2) ◽  
pp. 147-150 ◽  
Author(s):  
S. Clark ◽  
C.K. Campbell ◽  
A. Sandison ◽  
D.I. Choa

Author(s):  
Xiang Liu ◽  
Hua Zou ◽  
Qiu-Jian Chen ◽  
Chang-Ming Lu

1999 ◽  
Vol 121 (3) ◽  
pp. 252-254 ◽  
Author(s):  
Richard L. Mabry ◽  
Bradley F. Marple ◽  
Cynthia S. Mabry

2004 ◽  
Vol 18 (6) ◽  
pp. 397-404 ◽  
Author(s):  
Sarah K. Wise ◽  
Giridhar Venkatraman ◽  
Justin C. Wise ◽  
John M. DelGaudio

2010 ◽  
pp. 127-135
Author(s):  
Matthew W. Ryan ◽  
Bradley F. Marple

2005 ◽  
Vol 19 (5) ◽  
pp. 452-457 ◽  
Author(s):  
Berrylin J. Ferguson ◽  
Donna B. Stolz

Background Bacterial biofilms may explain why some patients with bacterial chronic rhinosinusitis (CRS) improve while on antibiotics but relapse after completion of the antibiotic. In the human host, biofilms exist as a community of bacteria surrounded by a glycocalyx that is adherent to a foreign body or a mucosal surface with impaired host defense. Biofilms generate planktonic, nonadherent bacterial forms that may metastasize infection and generate systemic illness. These planktonic bacteria are susceptible to antibiotics, unlike the adherent biofilm. Methods We reviewed four cases of CRS using transmission electron microscopy (TEM) to assay for typical colony architecture of biofilms. Bacterial communities surrounded by a glycocalyx of inert cellular membrane materials consistent with a biofilm were shown in two patients. Results In the two patients without biofilm, a nonbacterial etiology was discovered (allergic fungal sinusitis) in one and in the other there was scant anaerobic growth on culture and the Gram stain was negative. Culture of the material from the biofilm grew Pseudomonas aeruginosa in both patients. Pseudomonas from the biofilm showed a glycocalyx, not present in Pseudomonas cultured for 72 hours on culture media. Both patients’ symptoms with bacterial biofilms were refractory to culture-directed antibiotics, topical steroids, and nasal lavages. Surgery resulted in cure or significant improvement. Conclusion Biofilms are refractory to antibiotics and often only cured by mechanical debridement. We believe this is the first TEM documentation of bacterial biofilms in CRS in humans.


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