scholarly journals Effect of Outlier Elimination on the 99th Percentile Upper Reference Limits of High-Sensitivity Cardiac Troponin I Assays Based on a Strictly Selected Healthy Reference Population

2022 ◽  
Vol 42 (3) ◽  
pp. 331-341
Author(s):  
Sunyoung Ahn ◽  
Hyun-Ki Kim ◽  
Woochang Lee ◽  
Sail Chun ◽  
Won-Ki Min
Keyword(s):  
Cardiac Troponin ◽  
Troponin I ◽  
High Sensitivity ◽  
Reference Population ◽  
Cardiac Troponin I ◽  
Reference Limits

Upper Reference Limits of High-Sensitivity Cardiac Troponin T in a General Population: Comparison with those of Sensitive Cardiac Troponin I

2013 ◽  
Vol 59 (03+04/2013) ◽  
Author(s):  
Camille Chenevier-Gobeaux ◽  
Sophie Bailleul ◽  
Alexandre Mzabi ◽  
Marie-Céline Blanc ◽  
Guillaume Lefevre
Keyword(s):  
General Population ◽  
Cardiac Troponin ◽  
Troponin I ◽  
Troponin T ◽  
High Sensitivity ◽  
Cardiac Troponin I ◽  
Cardiac Troponin T ◽  
Population Comparison ◽  
Reference Limits

Determination of the High-Sensitivity Cardiac Troponin I 99th Percentile Upper Reference Limits in Malaysian Population

2018 ◽  
Vol 273 ◽  
pp. 22
Author(s):  
lntan Nureslyna Samsudin ◽  
Lim Say Min ◽  
Subashini C. Thambiah ◽  
Siti Yazmin Zahari Sham ◽  
Roslina Omar ◽  
...  
Keyword(s):  
Cardiac Troponin ◽  
Troponin I ◽  
High Sensitivity ◽  
Cardiac Troponin I ◽  
Malaysian Population ◽  
Reference Limits

scholarly journals Establishing the 99th percentile for high sensitivity cardiac troponin I in healthy blood donors from Southern Italy

2019 ◽  
Vol 29 (2) ◽  
pp. 402-406 ◽  
Author(s):  
Luisa Agnello ◽  
Giulia Bivona ◽  
Marcello Ciaccio ◽  
Bruna Lo Sasso ◽  
Maddalena Muratore ◽  
...  
Keyword(s):  
Single Molecule ◽  
Cardiac Troponin ◽  
Blood Donors ◽  
Troponin I ◽  
Parametric Method ◽  
High Sensitivity ◽  
Reference Population ◽  
Cardiac Troponin I ◽  
Healthy Population ◽  
Males And Females

Introduction: The knowledge of high sensitivity cardiac troponin I (hsTnI) distribution in a reference population is mandatory for its introduction in clinical practice. The aim of this study was to define the Upper Reference Limit (URL) of hsTnI measured by Single Molecule Counting technology (SMC) in an accurately selected reference population. Materials and methods: In the study 1140 blood donors were included and selected on the basis of medical history and biomarkers. High sensitivity cardiac troponin I was measured by SMC technology (Clarity, Singulex, Alamed, USA). The 99th percentile was calculated by the non-parametric method according to the Clinical and Laboratory Standard Institute - CLSI C28-A3. Results: The median age was 41 years (IQR: 28 - 50) and 69% were males. The overall 99th percentile was 5 ng/L (90% CI: 4.2 - 5.6). When considering sex-related differences, we found slight differences between the 99th percentile in males and females. Moreover, the 99th percentile trended with age, especially in females. Conclusions: We defined the 99th percentile of hs-cTnI measured by SMC technology in a highly selected healthy population, with only minor differences between males and females. Our findings provide the basic criteria for the reliable interpretation of hsTnI concentrations measured by the SMC technology in clinical settings.

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