Characteristics of cognitive function in patients with diabetes mellitus type 1 younger depending transferred hypoglycemic conditions

Depression Scale ◽

Diabetes Mellitus Type ◽

Patients With Diabetes

Many studies focus on the effect of compensation of diabetes, glucose-lowering therapy of choice, the influence of cardio - vascular diseases in the state of cognition. At the same time, not enough attention is paid to cognitive impairment in patients with type 1 diabetes mellitus, especially young people. The aim of our study was to investigate the prognostic factors of dementia in patients with type 1 diabetes mellitus are younger. 33 patients were examined with type 1 diabetes and 10 people in the control group. Of the 33 patients with diabetes, 21 people had hypoglycemia in the last 3 months and 12 without hypoglycemic states. To identify depression used two questionnaires: Centre for Epidemiologic Studies Depression Scale (CES-D) and the Hospital Anxiety and Depression Scale (HAD). Evaluation of cognitive impairment was conducted using the following methods: The test "5 words", sample Schulte, the scale of assessment of mental status ( MMSE), test battery on the frontal dysfunction (BLD), evaluation of test o’clock. To reveal the 10-year risk of dementia patients used the scale which was developed by a team of researchers at Utrecht University Medical Rudolf Magnus. In patients with type 1 diabetes with hypoglycemia marked deterioration in cognitive function, according to the neuropsychological tests, namely the BLD and MMSE compared with patient without hypoglycemia. The risk of developing dementia over 10 years in patients with diabetes mellitus type 1 young up 2.2 times compared with patients without hypoglycemia. Hypoglycemic state is the main risk factor that leads to the development of cognitive impairment, and this is a factor which can be influenced by insulin properly selected.

Variability of glycemia and cognitive impairment in patients with diabetes mellitus type 1.

Clinical Medicine (Russian Journal) ◽

10.18821/0023-2149-2018-96-8-741-745 ◽

2018 ◽

Vol 96 (8) ◽

pp. 741-745

Author(s):

Yu. G. Samoylova ◽

M. V. Matveeva ◽

N. G. Zhukova ◽

M. A. Rokank

Keyword(s):

Diabetes Mellitus ◽

Type 1 Diabetes ◽

Cognitive Impairment ◽

Cognitive Functions ◽

Risk Index ◽

Diabetes Mellitus Type ◽

The Relationship

Diabetes mellitus type 1 is associated with impaired cognitive function. Based on the results of systematic reviews and meta-analyzes, the most likely modifiable risk factor is the degree of metabolic control, in particular the variability of glycemia. Aims: to determine the influence of the variability of glycemia on cognitive functions in patients with type 1 diabetes mellitus. Material and methods. Design-observational, one-stage, cross-sectional research. We examined 30 patients with type 1 diabetes mellitus who were divided into 2 groups: 1 group (main) with cognitive impairment, and 2 (control) with normal cognitive functions. All patients were screened for cognitive functions using the Montreal scale (MoCa test). For the diagnosis of fluctuations in glucose level, continuous monitoring of glycemia was carried out using the iPro-2 device (Medtronic, USA): mean glycemic mean (MEAN), standard deviation (SD), mean amplitude of glycemic fluctuation (MAGE), long-term glycemic index (CONGA) Glycemia lability index (LI), hypoglycemia risk index (LBGI), hyperglycemia risk index (HBGI), mean hourly rate of glycemic change (MAG). Results. The study revealed that in patients with type 1 diabetes mellitus, cognitive impairment was dominated by a violation of constructive praxis, memory and attention. Recorded a significant difference in MEAN, SD, CONGA, Gindex, LBGI, HBGI, MAGE, Mvalue and MAG. Correlation analysis revealed the relationship of cognitive impairments with the level of HbA1c, as well as the variability parameters MEAN, SD, CONGA, Gindex, LBGI, HBGI, MAGE, Mvalue, MAG. Conclusions. The relationship between the variability of glycemia and cognitive impairment was registered in patients with type 1 diabetes mellitus

Diabetes Mellitus Type-1 and Psychosocial Intervention to Improve Quality of Life

Open Access Indonesian Journal of Medical Reviews ◽

10.37275/oaijmr.v1i4.46 ◽

2021 ◽

Vol 1 (4) ◽

pp. 80-85

Author(s):

Sarah Amalia

Keyword(s):

Quality Of Life ◽

Diabetes Mellitus ◽

Type 1 Diabetes ◽

Diabetes Mellitus Type ◽

Self Control ◽

Comprehensive Treatment

Type 1 diabetes mellitus is the most common chronic endocrine pathology among children. Data from the Indonesian Pediatric Association (IDAI) states that the incidence of DM in children aged 0-18 years has increased by 700% over a period of 10 years. Treatment includes diet, physical activity, insulin medication, and proper self-control. The necessary changes in habits and lifestyles can lead to psychosocial problems, including anxiety, depression and eating disorders. Subsequently, the child or adolescent and his or her family group may move into new balance characterized by good self-control and adherence to treatment, or deepen individual and group disorders which may reappear, especially in adolescence. The comprehensive treatment of type 1 diabetes mellitus requires addressing these aspects through multidisciplinary teams which include medical and psychosocial professionals. This review analyses the main aspects related to the psychosocial impact of diabetes mellitus type 1 among children, adolescents and their families mental. A substantial amount of behavioral science research has demonstrated that psychosocial factors play an integral role in the management of diabetes in both children and adults. Research has also shown how psychosocial therapies that can improve regimen adherence, glycemic control, psychosocial functioning, and quality of life.

The condition of mammary glands in women with diabetes mellitus type 1

Journal of obstetrics and women s diseases ◽

10.17816/jowd67338-43 ◽

2018 ◽

Vol 67 (3) ◽

pp. 38-43

Author(s):

Ekaterina V. Musina ◽

Igor Yu. Kogan ◽

Natalia V. Borovik

Keyword(s):

Diabetes Mellitus ◽

Type 1 Diabetes ◽

Mammary Gland ◽

Mammary Glands ◽

Diabetes Mellitus Type ◽

Diabetic Mastopathy ◽

Fibrocystic Mastopathy ◽

Patients With Diabetes

Background. The pathogenesis of diabetic mastopathy is unknown. It is assumed that one of the important factors in the development of this disease may be hyperglycemia. The aim of this study was to evaluate the clinical manifestations and echographic features of the mammary gland structure in women with diabetes mellitus type 1. Materials and methods. The three groups of women were examined: group 1: women with type 1 diabetes, with the onset of the disease before menarche (n = 58); group 2: women with type 1 diabetes, with the onset of the disease after menarche (n = 56); group 3: women with fibrocystic mastopathy, without diabetes mellitus type 1 (n = 79). Mastalgia was evaluated using the visual analogue scale. The ultrasound examination of mammary glands was performed on day 5 to 7 of the menstrual cycle. Results. The patients of all groups complained of mastalgia. Mammary gland ultrasound revealed that the thickness of the glandular tissue in patients of the first group was significantly less than in the second and third group. The diameter of the milk ducts was also significantly different in patients in each study group. In the group of patients with fibrocystic mastopathy without diabetes mellitus type 1, the tissue echogenicity is average in 41.8% of subjects, with it elevated in 58.2% of individuals. Moreover, in groups of patients with diabetes, 90% of subjects have increased echogenicity of breast tissue. Conclusion. Diabetic mastopathy is characterized by a fibrotic echo version of the organ parenchyma, which can be caused by a violation of the mammary gland formation and function in patients with diabetes mellitus type 1.

Стоматология детского возраста и профилактика ◽

Assessment of peridontal vessels hemodynamics among patients with diabetes mellitus type 1

10.33925/1683-3031-2020-20-1-9-14 ◽

2020 ◽

Vol 20 (1) ◽

pp. 9-14

Author(s):

L. Yu. Orekhova ◽

R. S. Musaeva ◽

E. S. Loboda ◽

Е. V. Grinenko ◽

G. Yu. Gulyanov

Keyword(s):

Diabetes Mellitus ◽

Blood Flow ◽

Type 1 Diabetes ◽

Oral Hygiene ◽

Periodontal Therapy ◽

Diabetes Mellitus Type ◽

Periodontal Tissues ◽

Patients With Diabetes

Relevance. Processes of disturbance of regional hemodynamics, tissue blood flow, insufficiency of transcapillary metabolism and antioxidant system caused by dysfunction of periodontal vascular endothelium among patients with diabetes type 1 directly lead to diabetic microangiopathy accompanied by decrease of level of microcirculation and perfusion of periodontal tissues among patients with absolute insulin insufficiency. The reduction of linear and volumetric blood flow rates in periodontal vessels among patients with type 1 diabetes compared to values obtained by ultrasonic dopplerography in healthy patients can be considered as distinctive features of the manifestation of this systemic disease on microcirculation of periodontal tissues.Purpose. To evaluate the hemodynamics of periodontal vessels among patients with diabetes mellitus type 1 and without diabetes before and after conservative periodontal therapy.Materials and methods. 40 patients at the age 20-30 years were surveyed: 20 patients with diabetes mellitus type 1 and 20 patients without diabetes. All subjects underwent dental examination. To study the state of microcirculation of periodontal tissues patients of both groups underwent high-frequency ultrasound Doppler “Minimax-doppler-k”. Further was conducted professional oral hygiene complex with training in rules of individual oral hygiene. Reexamination was scheduled after 4 weeks. Results. During the conduction have been registered average baseline of the linear (Vam) and volumetric (Qam) blood flow in periodontal vessels in patients with diabetes mellitus type 1 and without diabetes. Average linear (Vam) and volumetric (Qam) blood flow before the conduction of professional oral hygiene complex were considerably lower compared to patients without diabetes. This points reduction of microcirculation and perfusion of periodontal tissues in patients with diabetes mellitus type 1 and without diabetes. Reassessment of blood flow in periodontal tissues in 4 weeks after professional oral hygiene revealed an increase in rate of microcirculation in periodontal tissues among patients with diabetes mellitus type 1 and without diabetes. Conclusion. Our study confirms the theory of hemodynamic impairment and local hemostasis in patients with type 1 diabetes, which is reflected in the appearance of trophic disorders of an inflammatory-dystrophic nature and a decrease in hemodynamic parameters. After conservative periodontal therapy, we revealed positive changes in hemodynamics of periodontal vessels, which was recorded using ultrasound dopplerography. Our results will allow us to select the optimal algorithms for the timely diagnosis, prevention and treatment of dental diseases in patients with type 1 diabetes in future.

HIPERGLIKEMIA PADA ANAK DENGAN DIAGNOSIS DIABETES MELLITUS TYPE-1 , DIFERENTIAL DIAGNOSTIC MATURITY ONSET DIABETES OF THE YOUNG (MODY)

Saintika Medika ◽

10.22219/sm.vol14.smumm2.7162 ◽

2018 ◽

Vol 14 (2) ◽

Author(s):

Diah Hermayanti ◽

Erlin Nursiloningrum

Keyword(s):

Diabetes Mellitus ◽

Type 1 Diabetes ◽

Diabetes Mellitus Type ◽

Maturity Onset Diabetes ◽

Onset Diabetes

Pendahuluan Diabetes mellitus (DM) merupakan penyakit metabolik ditandai oleh hiperglikemia yang disebabkan berkurangnya produksi atau kerja insulin. DM dapat menyerang anak-anak. Kami melaporkan kasus hiperglikemia pada anak berusia 9 tahun dengan kadar C-peptida dalam batas normal.KasusAnak perempuanberusia 9 tahun, dibawa ke rumah sakit dikeluhkan lemah badan selama satu minggu. Pasien juga dikeluhkan sering kencing terutama di malam hari selama sebulan dan bekas kencing dirubung oleh semut. Pemeriksaan fisik dalam batas normal. Pemeriksaan laboratorium hari pertama : hemoglobin 14,8 g/dl, leukosit 9.860 sel/ul, trombosit 297.000 sel/ul, gula darah acak 328 mg/dl. Pemeriksaan hari kedua : gula darah puasa 274 mg/dl, gula darah 2 jam post prandial 370 mg/dl, dan glukosuria. Pemeriksaan C-Peptida 2,74 ng/ml (normal 1,1 – 4,4 ng/ml)PembahasanPada pasien anak ini ditemukan gejala khas diabetes yaitu fatigue dan poliuri. Pada pemeriksaan laboratorium didapatkan hiperglikemia. Sesuai dengan pedoman dari PERKENI pasien ini didiagnosis sebagai DM, yaitu tipe-1, dengan diferential diagnosis Maturity onset diabetes of the young (MODY) mengingat kadar C-peptida dalam batas normal. DM tipe 1 disebabkan oleh karena kerusakan sel beta pankreas akibat adanya autoantibodi terhadap pankreas. Sedangkan MODY disebabkan oleh mutasi genetik pada sel β pankreas sehingga terjadi inefektifitas produksi atau gangguan pelepasan insulin. Pemeriksaan tambahan seperti deteksi antibodi sel islet disarankan untuk menetapkan diagnosis DM tipe 1, dan pemeriksaan genetik untuk mendeteksi terjadinya mutasi sel β pankreas.SimpulanDiagnosis Type-1 Diabetes mellitus, dengan diagnosis banding Maturity onset diabetes of the young(MODY)Kata Kunci: hiperglikemia anak, C-peptida, Diabetes mellitus tipe-1, MODY